Protein Alignment CDKL1 and mcs6

DIOPT Version :10

• Sequence 1: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_596349.1
• Gene: mcs6 / 2540471
• PomBaseID: SPBC19F8.07
• Length: 335
• Species: Schizosaccharomyces pombe
• Alignment Length: 332
• Identity: 120/332 - (36%)
• Similarity: 178/332 - (53%)
• Gaps: 35/332 - (10%)

Human     4 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLE 68
            |.|..|:|||:|.|||..|.::|.:.|||||....:....|...|||||:.|::.:|.|::.|::
pombe    11 YVKERKVGEGTYAVVFLGRQKETNRRVAIKKIKVGQFKDGIDISALREIKFLRESRHDNVIELVD 75

Human    69 VFRRKRRLHLVFEYCDHTVLHEL---DRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPE 130
            ||..|..|:::.|:.|..:  |:   |::....|.| :||.....|:.::..|....:|||:||.
pombe    76 VFSTKSNLNIILEFLDSDL--EMLIKDKFIVFQPAH-IKSWMVMLLRGLHHIHSRFILHRDLKPN 137

Human   131 NILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL 195
            |:||:...|:||.|||.:|....|| :.:..|.|||||.|||.:|...||..||:|::||:||||
pombe   138 NLLISSDGVLKLADFGLSRDFGTPS-HMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAEL 201

Human   196 LSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQ---YFSGVKIPDPE-DMEPLELKFPNI 256
            :...|..||:||:|||.:|.:.||  .|..:.:.|..|   |.....||.|. .||.|   |...
pombe   202 MLRTPYLPGESDLDQLNVIFRALG--TPEPEVIKSMQQLPNYVEMKHIPPPNGGMEAL---FSAA 261

Human   257 SYPALGLLKGCLHMDPTQRLTCEQLLHHPYF------------------ENIREI-EDLAKEHNK 302
            .:..:.|||..|..:|.:|.|.:|.|.|.||                  |.|:.: .||.:::|.
pombe   262 GHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSALPKPTHPSLLPRKGGEEGIKHVSSDLQRQNNF 326

Human   303 PTRKTLR 309
            |.|..::
pombe   327 PMRANIK 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	111/289 (38%)
		[NKR]KIAxRE	45..51		2/5 (40%)
mcs6	NP_596349.1	STKc_CDK7	11..305	CDD:270833	113/302 (37%)