DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GALR2 and npr-9

DIOPT Version :9

Sequence 1:	NP_003848.1	Gene:	GALR2 / 8811	HGNCID:	4133	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_001361821.1	Gene:	npr-9 / 191320	WormBaseID:	WBGene00013974	Length:	431	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	125/396 - (31%)
Similarity:	192/396 - (48%)	Gaps:	85/396 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    26 VIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDG 90
            :|:|.:||:|.|||.|||.||:.|.. |.|..::||..|:.|.::||.|:|.||||.|..|....
Worm    30 IIIPTIFAVIILVGLVGNALVVIVAF-GRQMRNSTNTLIIGLAISDLMFLLLCVPFTAVDYAAPT 93

Human    91 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLL 155
            |:|....|..::|....:.:.|.:||..::||||||:.||:.|..||||||.:.|:..|:.:.:.
Worm    94 WIFPEWTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVESMTLRTPRNTVIALCFIYIIIIA 158

Human   156 -------FSGPYLSYY---RQSQLANLTVCHPAWSAPRRRAMDICTF-VFSYLLPVLVLGLTYAR 209
                   ..|.|:..:   ::|..|.||:. .|.:.|........|| ||.|:||:.:..:.|..
Worm   159 SQIPVGRMHGIYVYDFIMEKRSTCAILTIA-TAEATPTMARTYFMTFNVFGYVLPLGISVVLYGL 222

Human   210 TLRYLW-------------RAVDPVAAGSGARR------AKRKVTRMILIVAALFCLCWMP---- 251
            .||.||             |.:....:||..||      |||||||::|.|...:.|||:|
Worm   223 MLRKLWDMPRPGNSQSVGGRNLTNRDSGSSIRRRPEATAAKRKVTRLVLCVLITWALCWLPLNVC 287

Human   252 --------------HHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 302
                          .|.:|:.:             ::|.|.:::|.|||:|||:|||:|:.||:|
Worm   288 FFMSGLAYPEPLVISHGVIMVI-------------VQIASQVLAYTNSCLNPILYALMSQSFREG 339

Human   303 FRTICAGLLGRAPGRASGRVCAAARG-------TH--------SGSVLE----RESSDLLHMSEA 348
            |..:...|:.:.   :.||.|...|.       ||        :.:|::    ..||.|...|.:
Worm   340 FIRVMKMLINKL---SRGRFCTNYRRSALRTELTHYNQTPAHPANTVVQVSNGERSSLLKDNSSS 401

Human   349 AGALRP 354
            |.:::|
Worm   402 ATSVQP 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GALR2	NP_003848.1	7tm_4	32..>177	CDD:304433	58/154 (38%)
GALR2	NP_003848.1	7tm_1	42..292	CDD:278431	94/297 (32%)
npr-9	NP_001361821.1	7tmA_AstA_R_insect	30..340	CDD:320224	109/324 (34%)
		TM helix 1	32..56	CDD:320224	13/24 (54%)
		TM helix 2	64..86	CDD:320224	11/21 (52%)
		TM helix 3	102..124	CDD:320224	4/21 (19%)
		TM helix 4	147..163	CDD:320224	2/15 (13%)
		TM helix 5	198..221	CDD:320224	7/22 (32%)
		TM helix 6	267..289	CDD:320224	8/21 (38%)
		TM helix 7	308..333	CDD:320224	12/37 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I3443
eggNOG	1	0.900	-	-		E33208_3B9CW
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2863
Inparanoid	1	1.050	170	1.000	Inparanoid score	I3155
Isobase	1	0.950	-	0	Normalized mean entropy	S5404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		otm15108
orthoMCL	1	0.900	-	-		OOG6_105726
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3950
SonicParanoid	1	1.000	-	-		X1132
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.710