Protein Alignment GALR2 and npr-9

DIOPT Version :10

• Sequence 1: NP_003848.1
• Gene: GALR2 / 8811
• HGNCID: 4133
• Length: 387
• Species: Homo sapiens
• Sequence 2: NP_001361821.1
• Gene: npr-9 / 191320
• WormBaseID: WBGene00013974
• Length: 431
• Species: Caenorhabditis elegans
• Alignment Length: 396
• Identity: 125/396 - (31%)
• Similarity: 192/396 - (48%)
• Gaps: 85/396 - (21%)

Human    26 VIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDG 90
            :|:|.:||:|.|||.|||.||:.|.. |.|..::||..|:.|.::||.|:|.||||.|..|....
 Worm    30 IIIPTIFAVIILVGLVGNALVVIVAF-GRQMRNSTNTLIIGLAISDLMFLLLCVPFTAVDYAAPT 93

Human    91 WVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLL 155
            |:|....|..::|....:.:.|.:||..::||||||:.||:.|..||||||.:.|:..|:.:.:.
 Worm    94 WIFPEWTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVESMTLRTPRNTVIALCFIYIIIIA 158

Human   156 -------FSGPYLSYY---RQSQLANLTVCHPAWSAPRRRAMDICTF-VFSYLLPVLVLGLTYAR 209
                   ..|.|:..:   ::|..|.||:. .|.:.|........|| ||.|:||:.:..:.|..
 Worm   159 SQIPVGRMHGIYVYDFIMEKRSTCAILTIA-TAEATPTMARTYFMTFNVFGYVLPLGISVVLYGL 222

Human   210 TLRYLW-------------RAVDPVAAGSGARR------AKRKVTRMILIVAALFCLCWMP---- 251
            .||.||             |.:....:||..||      |||||||::|.|...:.|||:|
 Worm   223 MLRKLWDMPRPGNSQSVGGRNLTNRDSGSSIRRRPEATAAKRKVTRLVLCVLITWALCWLPLNVC 287

Human   252 --------------HHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKG 302
                          .|.:|:.:             ::|.|.:::|.|||:|||:|||:|:.||:|
 Worm   288 FFMSGLAYPEPLVISHGVIMVI-------------VQIASQVLAYTNSCLNPILYALMSQSFREG 339

Human   303 FRTICAGLLGRAPGRASGRVCAAARG-------TH--------SGSVLE----RESSDLLHMSEA 348
            |..:...|:.:.   :.||.|...|.       ||        :.:|::    ..||.|...|.:
 Worm   340 FIRVMKMLINKL---SRGRFCTNYRRSALRTELTHYNQTPAHPANTVVQVSNGERSSLLKDNSSS 401

Human   349 AGALRP 354
            |.:::|
 Worm   402 ATSVQP 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GALR2	NP_003848.1	7tmA_Gal2_Gal3_R	26..303	CDD:320225	109/324 (34%)
		TM helix 1	27..53	CDD:320225	14/25 (56%)
		TM helix 2	60..86	CDD:320225	13/25 (52%)
		TM helix 3	98..128	CDD:320225	11/29 (38%)
		TM helix 4	140..160	CDD:320225	5/26 (19%)
		TM helix 5	184..213	CDD:320225	9/29 (31%)
		TM helix 6	229..259	CDD:320225	16/53 (30%)
		TM helix 7	271..296	CDD:320225	12/24 (50%)
npr-9	NP_001361821.1	7tmA_AstA_R_insect	30..340	CDD:320224	109/324 (34%)
		TM helix 1	31..57	CDD:320224	14/26 (54%)
		TM helix 2	63..89	CDD:320224	13/25 (52%)
		TM helix 3	101..131	CDD:320224	11/29 (38%)
		TM helix 4	143..163	CDD:320224	4/19 (21%)
		TM helix 5	197..226	CDD:320224	9/28 (32%)
		TM helix 6	261..291	CDD:320224	13/29 (45%)
		TM helix 7	308..333	CDD:320224	12/37 (32%)