Protein Alignment IL18R1 and zmp:0000000936

DIOPT Version :9

• Sequence 1: NP_003846.1
• Gene: IL18R1 / 8809
• HGNCID: 5988
• Length: 541
• Species: Homo sapiens
• Sequence 2: XP_021334731.1
• Gene: zmp:0000000936 / 799204
• ZFINID: ZDB-GENE-130530-939
• Length: 580
• Species: Danio rerio
• Alignment Length: 594
• Identity: 153/594 - (25%)
• Similarity: 256/594 - (43%)
• Gaps: 126/594 - (21%)

Human    12 VLISVSTAESC----TSRPHITVVEGEPFYLKHCSCSLAH----EIETTTKSWYKSSGSQEHVEL 68
            |:.:....|||    .:...:..:.||...|: |..|:.:    |..:...|||
Zfish    20 VISNKDPLESCQDFGLAFERVFALPGEASVLE-CPLSIDYLFDPEETSYNVSWY----------- 72

Human    69 NPRSSSRI-ALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEV 132
            |.::.|.| |:...|:      |.:...:||.:....| .|...:.|....||  :|||..|  |
Zfish    73 NVKTGSEITAVEHSVI------LKENSLWFFNVSKQHQ-GKYRCVVRTSSKCF--KQVTMLI--V 126

Human   133 KKFFQITCE---------------------NSYYQTLVNST-SLYKNCKKLLLENNKNPTIKKNA 175
            .:....|||                     ..|.:|:.... ..|||| :|:.|:.|   ...|.
Zfish   127 SEMTSETCERPQRSIQNIKAHVNDLLACPLRRYLKTVDRPVIQWYKNC-ELIQEDEK---FSINR 187

Human   176 EF--------EDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKN 232
            ||        :|.|:|||.......|....:.:|.... |:|.....|.::.|....:.:|.|.:
Zfish   188 EFLYIRKVHEDDAGFYSCKMSFTLAGVAGEMAETIECE-VQDEYLKKPQVIQPVNEIIRMEEGSS 251

Human   233 VRLNC----------------SALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKV 281
            ...:|                ..|:.||:    .|..:|.|. .||::.....:|.:| :...:.
Zfish   252 FSKDCVVVMLGKGIPLIEVLWKVLVEEEE----EFVTQNMSH-RIHQKPRNESVTADG-FVFVRT 310

Human   282 LRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVT 346
            |.:.::.|.:..:.:.|.|:|:.|..|..|:|: ..|    |..:...|:::.:|.|. ....|.
Zfish   311 LSVSHVSEDDFYLNFTCLVSSSRGHLTGQFMLI-PTD----PDLLLFAGLLLGLLALF-FTSAVF 369

Human   347 VCVIYRVDLVLFYR------HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLE 405
            :|.:::|:|||:.|      :.|    |..|||.|||:::|.:.....:.:...||:..||::||
Zfish   370 LCSVFKVELVLWVRTAFPFLYKT----TDGDGKQYDAYIAYPRVLEGSSEKAEVFAMSTLPQILE 430

Human   406 KHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYM-SNEVR--YELESGLHEALVER 467
            ..:||||.|..||.:||.||||.:...:.:.|||:::.:.|.: |.|.:  .|.::|||.|||:.
Zfish   431 GRYGYKLFILGRDGLPGEAVVDVVQEALSRCRRLLLLYTASSLCSPEAQEWAEQQTGLHRALVDH 495

Human   468 KIKIILIEFTPVTDFTFLPQSLKLLKSHR-VLK-WKADK----------------SLSYNSRFWK 514
            .:.|:|:|...:.|...||.:::|||..: ||: ||..:                ||..:.||||
Zfish   496 SMSIVLLELEEIRDPLCLPLAIRLLKDKQGVLQAWKRRRRWGWAIQDRRSEERTSSLQPSERFWK 560

Human   515 NLLYLMPAK 523
            .:.:.||.:
Zfish   561 EVRFHMPVR 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IL18R1	NP_003846.1	Ig	28..100	CDD:325142	17/76 (22%)
		Ig	129..208	CDD:325142	24/108 (22%)
		PHA02785	<171..312	CDD:333475	34/164 (21%)
		TIR	378..520	CDD:307630	52/162 (32%)
zmp:0000000936	XP_021334731.1	PHA02785	28..209	CDD:333475	50/207 (24%)
		Ig2_IL1R_like	138..228	CDD:319309	20/94 (21%)
		TIR_2	399..569	CDD:329054	57/169 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28PSC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D339368at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11890
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920