DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL18R1 and Il18r1

DIOPT Version :9

Sequence 1:	NP_003846.1	Gene:	IL18R1 / 8809	HGNCID:	5988	Length:	541	Species:	Homo sapiens
Sequence 2:	NP_032391.1	Gene:	Il18r1 / 16182	MGIID:	105383	Length:	537	Species:	Mus musculus

Alignment Length:	541	Identity:	348/541 - (64%)
Similarity:	410/541 - (75%)	Gaps:	8/541 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSL-AHEIETTTKSWYKSSGSQE 64
            |:..||.|||.:||..|.::||..|..|.||||||||||.|..|. .|..||.|..|:|.|.|.|
Mouse     1 MHHEELILTLCILIVKSASKSCIHRSQIHVVEGEPFYLKPCGISAPVHRNETATMRWFKGSASHE 65

Human    65 HVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKI 129
            :.|||.|||.|:..||..|||||||:.|.|:|..|:.|..:.|.|||.:|||||||:::.|||:.
Mouse    66 YRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYISQVGNDRRNWTLNVTKRNKHSCFSDKLVTSRD 130

Human   130 VEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGK 194
            |||.|...|||:|..|:.|:..|.||||||::    :|.|.|.|:|||.|:||||||..:||||.
Mouse   131 VEVNKSLHITCKNPNYEELIQDTWLYKNCKEI----SKTPRILKDAEFGDEGYYSCVFSVHHNGT 191

Human   195 LFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDP 259
            .:|||||.|||::|.||.:.|.:||||...|.|||||:|.|||||.||::|:.||...:|:.|||
Mouse   192 RYNITKTVNITVIEGRSKVTPAILGPKCEKVGVELGKDVELNCSASLNKDDLFYWSIRKEDSSDP 256

Human   260 NIHEE-KEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIP 323
            |:.|: ||......|||.||||:||.:.|.|:.||||||||||:....|||||:|||| ::.|||
Mouse   257 NVQEDRKETTTWISEGKLHASKILRFQKITENYLNVLYNCTVANEEAIDTKSFVLVRK-EIPDIP 320

Human   324 GHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPE 388
            |||||.|:.:.||..||.||:|.:||||:||||||||.:..|||||||||||||||||||||.||
Mouse   321 GHVFTGGVTVLVLASVAAVCIVILCVIYKVDLVLFYRRIAERDETLTDGKTYDAFVSYLKECHPE 385

Human   389 NGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVR 453
            |.||:|||||.|||||||.|||||||||||||||||||:|||||||||||||||||:||::|..|
Mouse   386 NKEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGAR 450

Human   454 YELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLY 518
            .||||||||||||||||||||||||.::.||||.|||||||:|||||:|| |.|.||||||||:|
Mouse   451 RELESGLHEALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLKWRAD-SPSMNSRFWKNLVY 514

Human   519 LMPAKTVKPGRDEPEVLPVLS 539
            |||||.|||.|:|.|...|||
Mouse   515 LMPAKAVKPWREESEARSVLS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL18R1	NP_003846.1	Ig	28..100	CDD:325142	41/72 (57%)
		Ig	129..208	CDD:325142	43/78 (55%)
		PHA02785	<171..312	CDD:333475	82/141 (58%)
		TIR	378..520	CDD:307630	118/141 (84%)
Il18r1	NP_032391.1	IG_like	26..112	CDD:214653	45/85 (53%)
		Ig	131..205	CDD:386229	43/77 (56%)
		PHA02785	<157..257	CDD:165149	58/103 (56%)
		TIR	374..534	CDD:366714	130/160 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955865
Domainoid	1	1.000	304	1.000	Domainoid score	I16040
eggNOG	1	0.900	-	-		E1_28PSC
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2861
Inparanoid	1	1.050	683	1.000	Inparanoid score	I9458
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG36927
OrthoDB	1	1.010	-	-		D339368at7742
OrthoFinder	1	1.000	-	-		FOG0012588
OrthoInspector	1	1.000	-	-		oto124445
orthoMCL	1	0.900	-	-		OOG6_121935
Panther	1	1.100	-	-	LDO	PTHR11890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12828
SonicParanoid	1	1.000	-	-		X10489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	18	18.340