Protein Alignment IL18R1 and il18r1

DIOPT Version :10

• Sequence 1: NP_003846.1
• Gene: IL18R1 / 8809
• HGNCID: 5988
• Length: 541
• Species: Homo sapiens
• Sequence 2: XP_012813128.1
• Gene: il18r1 / 101732855
• XenbaseID: XB-GENE-483624
• Length: 572
• Species: Xenopus tropicalis
• Alignment Length: 551
• Identity: 186/551 - (33%)
• Similarity: 293/551 - (53%)
• Gaps: 55/551 - (9%)

Human    31 VEGEPFYLKHCSCSLAHEIETTTK------SWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVE 89
            |:|| .|:..|..|....:|...|      :|.:.. |...|::...::|||......|:|||:.
 Frog    29 VDGE-HYVLQCLWSDPVLVENMLKNNESSITWNRIQ-SDVDVKITTDNTSRIISKGHKLQFWPIY 91

Human    90 LNDTGSYFFQMKNYTQKW-KLNVIRRNKHSCFT---ERQVTSK----IVEVKKFFQITCENSYYQ 146
            |||:|.|:..:::...:. ::.|:.:::..|.|   |::.|:.    :|....|.:.....:.|.
 Frog    92 LNDSGDYYCSIQDTESRGIRIKVVLKSEKQCNTPCNEKKKTNMGMHVVVNFLPFERYRDSGTNYS 156

Human   147 TLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRS 211
            .:|     ||||.  :...|.:.......:..|:..|:.|..:..||:.::.::...:.:.....
 Frog   157 IVV-----YKNCD--IYAFNVSQISFDAVQKSDEADYAFVLMIPRNGRTYSFSRRTKLIVNVCIE 214

Human   212 NIVPVLLGP-KLNHVAVELGKNVRLNCSALLN------EEDVIYWMFGEENGSDPNIHEEKEM-- 267
            ||.|.|.|. .:.::.:|||.|..|.|.|.|.      .:..::|:......::.|. |.||.
 Frog   215 NIKPYLRGTGNVTNLDIELGTNFTLQCEAFLGYCQRALYDVTMFWLQLNSKRTESNA-EHKEQYD 278

Human   268 ------------RIMTPE------GKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILV 314
                        |..||:      |...|..||:|.:..|.::...|.|.:.:|.|..:::|.|.
 Frog   279 FVEGCSSNITYKRCYTPQKILYANGSLTAITVLQINDANEYDVKNYYKCKMDTTNGGGSRAFNLR 343

Human   315 RKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFV 379
            .|....||...|||:.:|:||:..:.:|.|..:||.:|:|:||.:|.|.:.|||..|||.:||::
 Frog   344 IKVKARDISRDVFTKSIIVAVICSLCIVLLAFLCVKFRIDIVLLWRTLKKTDETNGDGKQFDAYL 408

Human   380 SYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLS 444
            |::.....|..||..||.:.||.|||..||||||||||||:|||..||::||.::|||||||:.|
 Frog   409 SFMSNPAAEEEEEIEFATKTLPMVLENLFGYKLCIFERDVIPGGVKVDDMHSFLDKSRRLIILFS 473

Human   445 KSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYN 509
            ::|:::...||||:|||:|:||||||:||||..|:.:...:|:||.||||...:||:.:||...|
 Frog   474 RNYIADNALYELEAGLHKAMVERKIKVILIECMPLHELNVVPESLHLLKSSNTVKWEGNKSRPLN 538

Human   510 SRFWKNLLYLMPAKTVKPG----RDEPEVLP 536
            |||||.:.||||:|.:...    .|:.||.|
 Frog   539 SRFWKQIQYLMPSKPINRQILLLNDKREVNP 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IL18R1	NP_003846.1	V-set	28..100	CDD:462230	23/74 (31%)
		Ig	129..208	CDD:472250	14/78 (18%)
		Ig strand B	136..140	CDD:409353	0/3 (0%)
		Ig strand E	168..172	CDD:409353	0/3 (0%)
		PHA02785	<171..312	CDD:165149	36/167 (22%)
		Ig strand F	182..187	CDD:409353	1/4 (25%)
		Ig strand G	199..202	CDD:409353	0/2 (0%)
		TIR	378..520	CDD:396246	76/141 (54%)
il18r1	XP_012813128.1	Ig_6	28..126	CDD:465773	26/98 (27%)
		TIR	403..552	CDD:214587	81/148 (55%)