DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL18R1 and il18r1.1

DIOPT Version :9

Sequence 1:	NP_003846.1	Gene:	IL18R1 / 8809	HGNCID:	5988	Length:	541	Species:	Homo sapiens
Sequence 2:	XP_012813128.1	Gene:	il18r1.1 / 101732855	XenbaseID:	XB-GENE-483624	Length:	572	Species:	Xenopus tropicalis

Alignment Length:	551	Identity:	186/551 - (33%)
Similarity:	293/551 - (53%)	Gaps:	55/551 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    31 VEGEPFYLKHCSCSLAHEIETTTK------SWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVE 89
            |:|| .|:..|..|....:|...|      :|.:.. |...|::...::|||......|:|||:.
Frog    29 VDGE-HYVLQCLWSDPVLVENMLKNNESSITWNRIQ-SDVDVKITTDNTSRIISKGHKLQFWPIY 91

Human    90 LNDTGSYFFQMKNYTQKW-KLNVIRRNKHSCFT---ERQVTSK----IVEVKKFFQITCENSYYQ 146
            |||:|.|:..:::...:. ::.|:.:::..|.|   |::.|:.    :|....|.:.....:.|.
Frog    92 LNDSGDYYCSIQDTESRGIRIKVVLKSEKQCNTPCNEKKKTNMGMHVVVNFLPFERYRDSGTNYS 156

Human   147 TLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRS 211
            .:|     ||||.  :...|.:.......:..|:..|:.|..:..||:.::.::...:.:.....
Frog   157 IVV-----YKNCD--IYAFNVSQISFDAVQKSDEADYAFVLMIPRNGRTYSFSRRTKLIVNVCIE 214

Human   212 NIVPVLLGP-KLNHVAVELGKNVRLNCSALLN------EEDVIYWMFGEENGSDPNIHEEKEM-- 267
            ||.|.|.|. .:.::.:|||.|..|.|.|.|.      .:..::|:......::.|. |.||.
Frog   215 NIKPYLRGTGNVTNLDIELGTNFTLQCEAFLGYCQRALYDVTMFWLQLNSKRTESNA-EHKEQYD 278

Human   268 ------------RIMTPE------GKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILV 314
                        |..||:      |...|..||:|.:..|.::...|.|.:.:|.|..:::|.|.
Frog   279 FVEGCSSNITYKRCYTPQKILYANGSLTAITVLQINDANEYDVKNYYKCKMDTTNGGGSRAFNLR 343

Human   315 RKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFV 379
            .|....||...|||:.:|:||:..:.:|.|..:||.:|:|:||.:|.|.:.|||..|||.:||::
Frog   344 IKVKARDISRDVFTKSIIVAVICSLCIVLLAFLCVKFRIDIVLLWRTLKKTDETNGDGKQFDAYL 408

Human   380 SYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLS 444
            |::.....|..||..||.:.||.|||..||||||||||||:|||..||::||.::|||||||:.|
Frog   409 SFMSNPAAEEEEEIEFATKTLPMVLENLFGYKLCIFERDVIPGGVKVDDMHSFLDKSRRLIILFS 473

Human   445 KSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYN 509
            ::|:::...||||:|||:|:||||||:||||..|:.:...:|:||.||||...:||:.:||...|
Frog   474 RNYIADNALYELEAGLHKAMVERKIKVILIECMPLHELNVVPESLHLLKSSNTVKWEGNKSRPLN 538

Human   510 SRFWKNLLYLMPAKTVKPG----RDEPEVLP 536
            |||||.:.||||:|.:...    .|:.||.|
Frog   539 SRFWKQIQYLMPSKPINRQILLLNDKREVNP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL18R1	NP_003846.1	Ig	28..100	CDD:325142	23/74 (31%)
		Ig	129..208	CDD:325142	14/78 (18%)
		PHA02785	<171..312	CDD:333475	36/167 (22%)
		TIR	378..520	CDD:307630	76/141 (54%)
il18r1.1	XP_012813128.1	Ig	27..102	CDD:299845	23/74 (31%)
il18r1.1	XP_012813128.1	TIR	403..552	CDD:214587	81/148 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I18194
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2861
Inparanoid	1	1.050	305	1.000	Inparanoid score	I10523
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120023at32523
OrthoFinder	1	1.000	-	-		FOG0012588
OrthoInspector	1	1.000	-	-		otm55088
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060