DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IL1RL2 and CG45263

DIOPT Version :9

Sequence 1:	XP_011510393.1	Gene:	IL1RL2 / 8808	HGNCID:	5999	Length:	622	Species:	Homo sapiens
Sequence 2:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster

Alignment Length:	224	Identity:	48/224 - (21%)
Similarity:	87/224 - (38%)	Gaps:	66/224 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    73 PPITSGEVSVTWYK--NSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIH 135
            ||     .|:.|.:  .|....:.:.:|.|           |:...|:|:|.|
  Fly   314 PP-----ASIVWRRAGRSEIASLQETLQLR-----------PVGRRDAGLYTC------------ 350

Human   136 VNLTVFEKHWCDTSIGGLPNLSDEY-----KQILHLGKDDSLTCHLHFPKS--CV-----LGPIK 188
                     ....|:|....||.:.     .:|:..|.|...|..|..|.:  |:     |...|
  Fly   351 ---------QAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLADGNPLPSFK 406

Human   189 WYKDCNEIKGERFTV--LETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSIKRAGYGG 251
            |.:  ....|.::..  .|:||::.||:.|.:|.|.|:|....:|::...::. .||::..|
  Fly   407 WVQ--RMAHGSKYVERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISD-PVSLQVVG--- 465

Human   252 SVPKI--IYPKNHSIEVQLG----TTLIV 274
             .|::  ::|..|::.|:.|    .|::|
  Fly   466 -APQVLRLHPSLHTVSVKRGEAASLTMVV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL1RL2	XP_011510393.1	Ig	54..140	CDD:299845	12/68 (18%)
		Ig2_IL1R_like	158..245	CDD:143234	24/100 (24%)
		IG_like	171..229	CDD:214653	18/66 (27%)
		TIR	413..563	CDD:279864
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845
		IG_like	302..368	CDD:214653	16/90 (18%)
		IGc2	302..357	CDD:197706	13/79 (16%)
		Ig	372..446	CDD:299845	21/75 (28%)
		Ig	475..568	CDD:299845	5/19 (26%)
		IG_like	478..570	CDD:214653	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910