DRSC/TRiP Functional Genomics Resources

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Protein Alignment IL18RAP and zmp:0000000936

DIOPT Version :9

Sequence 1:NP_001380415.1 Gene:IL18RAP / 8807 HGNCID:5989 Length:599 Species:Homo sapiens
Sequence 2:XP_021334731.1 Gene:zmp:0000000936 / 799204 ZFINID:ZDB-GENE-130530-939 Length:580 Species:Danio rerio


Alignment Length:544 Identity:132/544 - (24%)
Similarity:232/544 - (42%) Gaps:104/544 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    81 DVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMI- 144
            :|.|| ....|..:..:..|   :|..:.:|.|......:.|.|.|   ::::.   :.|.|.: 
Zfish    68 NVSWY-NVKTGSEITAVEHS---VILKENSLWFFNVSKQHQGKYRC---VVRTS---SKCFKQVT 122

Human   145 -LEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERS---NR 205
             |.|...|:.:||......|::.......::||..........|.:.||||.:|:..:..   ||
Zfish   123 MLIVSEMTSETCERPQRSIQNIKAHVNDLLACPLRRYLKTVDRPVIQWYKNCELIQEDEKFSINR 187

Human   206 --IVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVV--QVRTI---VGDTKL-KPDILDPVEDTLE 262
              :.:.:|::...|.|.|.       .|:|:..|.  ...||   |.|..| ||.::.||.:.:.
Zfish   188 EFLYIRKVHEDDAGFYSCK-------MSFTLAGVAGEMAETIECEVQDEYLKKPQVIQPVNEIIR 245

Human   263 VELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKS----------------T 311
            :|.|...:..|......:.:  |:|       ::.|:|.|.|.:...:                |
Zfish   246 MEEGSSFSKDCVVVMLGKGI--PLI-------EVLWKVLVEEEEEFVTQNMSHRIHQKPRNESVT 301

Human   312 LKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLY--ILLGTIGTLVAV 374
            ....:..|.:.:..|::.|....|.|.|.:|.|:.|....|......:||:  :|||    |:|:
Zfish   302 ADGFVFVRTLSVSHVSEDDFYLNFTCLVSSSRGHLTGQFMLIPTDPDLLLFAGLLLG----LLAL 362

Human   375 LAASAL----LYRHWIEIVLLYRT-----YQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSE 430
            ...||:    :::  :|:||..||     |::.|   ||.|.:||:::|.:.....||     ..
Zfish   363 FFTSAVFLCSVFK--VELVLWVRTAFPFLYKTTD---GDGKQYDAYIAYPRVLEGSSE-----KA 417

Human   431 EHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSI---F 492
            |..|:|..|.:||.:|||.|.:|.||..||....:.:...:.|.||.:.:.:.:.:..|..   .
Zfish   418 EVFAMSTLPQILEGRYGYKLFILGRDGLPGEAVVDVVQEALSRCRRLLLLYTASSLCSPEAQEWA 482

Human   493 ELQAAVNLALDDQTLKLILIKFCYFQEPESLP---HLVKKALRVLPTVTWRGLK----------- 543
            |.|..::.||.|.::.::|::....::|..||   .|:|....||.  .|:..:           
Zfish   483 EQQTGLHRALVDHSMSIVLLELEEIRDPLCLPLAIRLLKDKQGVLQ--AWKRRRRWGWAIQDRRS 545

Human   544 -----SVPPNSRFWAKMRYHMPVK 562
                 |:.|:.|||.::|:||||:
Zfish   546 EERTSSLQPSERFWKEVRFHMPVR 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IL18RAPNP_001380415.1 Ig_6 100..155 CDD:408247 12/56 (21%)
Ig 162..>221 CDD:416386 14/63 (22%)
Ig strand A 162..166 CDD:409353 1/3 (33%)
Ig strand B 171..175 CDD:409353 0/3 (0%)
Ig strand C 188..193 CDD:409353 1/4 (25%)
Ig strand C' 196..198 CDD:409353 0/1 (0%)
Ig strand E 204..209 CDD:409353 2/6 (33%)
Ig 251..354 CDD:416386 23/118 (19%)
Ig strand A 251..254 CDD:409353 1/2 (50%)
Ig strand A' 262..265 CDD:409353 0/2 (0%)
Ig strand B 267..276 CDD:409353 1/8 (13%)
Ig strand C 285..290 CDD:409353 2/4 (50%)
Ig strand D 300..308 CDD:409353 3/7 (43%)
Ig strand E 315..323 CDD:409353 1/7 (14%)
Ig strand F 334..340 CDD:409353 2/5 (40%)
Ig strand G 344..350 CDD:409353 2/5 (40%)
TIR 419..559 CDD:396246 41/161 (25%)
zmp:0000000936XP_021334731.1 PHA02785 28..209 CDD:333475 33/157 (21%)
Ig2_IL1R_like 138..228 CDD:319309 21/96 (22%)
TIR_2 399..569 CDD:329054 47/176 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28PSC
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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