DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL18RAP and Toll-4

DIOPT Version :9

Sequence 1:	NP_001380415.1	Gene:	IL18RAP / 8807	HGNCID:	5989	Length:	599	Species:	Homo sapiens
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	130/640 - (20%)
Similarity:	232/640 - (36%)	Gaps:	180/640 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    14 GERIKGFNISGCSTKKL-------LWTYSTRSEEEFVLFCDLPEPQKSHFCH-----------RN 60
            |...|.||:      ||       :|.:|...:|..:...:.|.|.:...|.           ||
  Fly   557 GPSDKYFNL------KLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRN 615

Human    61 ---RLSPKQVPEHLP-----FMGSNDLSDVQWYQQPSNGDPL--------------EDIRKSYP- 102
               .:.|: :|..:|     ::..|::      ::.:|.:.|              :::.:..|
  Fly   616 LSLDIYPR-LPNSIPYKTTLYLDRNEI------RKLTNTESLVVAGHASIHKLHMSQNLLRELPL 673

Human   103 HIIQDKCT--------LHFLTPGVNNSGSY---ICRPKMIKSPYDVACCVKMILEVKPQTNASCE 156
            |::.:..|        |.:|..||.....|   |.:.::..:|::..|..|..|... :.:...|
  Fly   674 HLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFL-RRHEPME 737

Human   157 YSASHKQDLLLGSTGSISCPS--LSCQSDAQSPAVTWYK--NGKLLSVERSNRIVVDEVYDYHQG 217
            |....::..:...    .||.  :.|...:.|.::.:..  :||.||     .|.......|.|.
  Fly   738 YETVLRRVEITDD----KCPEDCICCVDTSNSDSLAYVVDCSGKELS-----EIPQLPTPTYGQT 793

Human   218 TYVCDYTQSDTVSSW---------TVRAVVQVRTIVGDTKLKPDILD----------PVEDTLEV 263
            |.|   .:.:::..|         :|.........:.|....||.|:          .::|.:..
  Fly   794 TLV---FERNSLKKWPSSLLPGYSSVTRFYLAHNRLSDIDQLPDKLEYLDISNNNFSALDDRVRG 855

Human   264 ELGKPLTIS--CKARFGFERVFNPVIKWYIKDSDLEWEVSVPE-AKSIKSTLKDEIIERNIILEK 325
            .|.|.:..|  ..:.||     ||   |..:..|.::.|.|.| ||:|.:....:.|:....|.:
  Fly   856 FLQKRMNSSQLQLSLFG-----NP---WTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIE 912

Human   326 VTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALL--------- 381
            |.:.|     :|                   ..||:|.....:..|:..|:.:..:
  Fly   913 VEETD-----IC-------------------PSVLIYYTSLAVSLLIIALSINVFICFRQPIMIW 953

Human   382 -YRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLEN- 444
             |.|.|.:.|..|      :.|.:.|.:|||:|:       :.....|.||      |.|.|||
  Fly   954 FYEHEICLSLAAR------RELDEDKKYDAFLSF-------THKDEDLIEE------FVDRLENG 999

Human   445 KYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGP-SIFELQAAVNLALDDQTLK 508
            ::.:.||...||...|....:.|...:|.|||.|.:::.|::... ...|.:.|::....|:..:
  Fly  1000 RHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKR 1064

Human   509 LILIKFC---YFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMP 560
            ||::.:.   :|.:.:|    ..:|..||.|...|.      |..||.|:.|.||
  Fly  1065 LIVVLYPDVEHFDDLDS----ELRAYMVLNTYLDRN------NPNFWNKLMYSMP 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL18RAP	NP_001380415.1	Ig_6	100..155	CDD:408247	13/66 (20%)
		Ig	162..>221	CDD:416386	12/62 (19%)
		Ig strand A	162..166	CDD:409353	0/3 (0%)
		Ig strand B	171..175	CDD:409353	0/3 (0%)
		Ig strand C	188..193	CDD:409353	0/4 (0%)
		Ig strand C'	196..198	CDD:409353	1/1 (100%)
		Ig strand E	204..209	CDD:409353	1/4 (25%)
		Ig	251..354	CDD:416386	24/115 (21%)
		Ig strand A	251..254	CDD:409353	2/2 (100%)
		Ig strand A'	262..265	CDD:409353	0/2 (0%)
		Ig strand B	267..276	CDD:409353	2/10 (20%)
		Ig strand C	285..290	CDD:409353	1/4 (25%)
		Ig strand D	300..308	CDD:409353	5/8 (63%)
		Ig strand E	315..323	CDD:409353	1/7 (14%)
		Ig strand F	334..340	CDD:409353	1/5 (20%)
		Ig strand G	344..350	CDD:409353	0/5 (0%)
		TIR	419..559	CDD:396246	37/144 (26%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380
		leucine-rich repeat	388..408	CDD:275380
		LRR_8	412..465	CDD:290566
		leucine-rich repeat	412..432	CDD:275378
		LRR_4	432..470	CDD:289563
		leucine-rich repeat	433..454	CDD:275378
		leucine-rich repeat	455..478	CDD:275378
		leucine-rich repeat	479..490	CDD:275378
		leucine-rich repeat	632..657	CDD:275378	3/30 (10%)
		leucine-rich repeat	658..679	CDD:275378	2/20 (10%)
		leucine-rich repeat	680..706	CDD:275378	6/25 (24%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	5/24 (21%)
		leucine-rich repeat	793..815	CDD:275378	3/24 (13%)
		leucine-rich repeat	816..835	CDD:275378	3/18 (17%)
		leucine-rich repeat	836..859	CDD:275378	3/22 (14%)
		TIR	974..1110	CDD:214587	43/159 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910