DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACTN2 and Ehbp1

DIOPT Version :9

Sequence 1:NP_001094.1 Gene:ACTN2 / 88 HGNCID:164 Length:894 Species:Homo sapiens
Sequence 2:NP_995865.2 Gene:Ehbp1 / 36912 FlyBaseID:FBgn0034180 Length:1141 Species:Drosophila melanogaster


Alignment Length:801 Identity:164/801 - (20%)
Similarity:285/801 - (35%) Gaps:289/801 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   116 SIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSW 180
            |||:.....|::..:|..:..|:|:         |.:..:.||.||:..|..|.||.:.|..|||
  Fly   432 SIGSCFSTSGSLNNSLKPVEKIVLK---------ENTPGQDLLEWCKEVTKDYPNVKVTNLTTSW 487

Human   181 KDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAI 245
            ::|:..||:||...|:|||.|||:..|.:||..:..:.||. |.||::::..|:.....||:.|:
  Fly   488 RNGMAFCAIIHHFVPELIDMSKLSAHDVVGNCRIGFDAAES-LGIPRVIEPRDMNMLTVPDKLAV 551

Human   246 MTYVSCFYHAFAG----AEQAETAANRICKVLAVNQENERLME---EYERLASELLEWIRRTIPW 303
            |||:......|.|    .||..:.|:....|:. :.:::.|.:   .:....|.||.        
  Fly   552 MTYLHQLRAHFTGKQLKIEQIGSTADESSYVIG-DYKSDNLSQNRINFSHPKSLLLH-------- 607

Human   304 LENRTPE------KTMQAMQKKLEDFRD---YRRKHKPPKVQEKCQLEINFNTLQ-----TKLRI 354
             :|...|      |:.|......:|.::   |..|:...||....:.:.:.|..|     ..|..
  Fly   608 -QNSFDEEINGSNKSEQLSPTSKKDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSC 671

Human   355 SNRPAFMPSE----------GKMVSDI------AGAWQR----LEQAEKGYEEWLLNEIR----- 394
            ...|   |.:          ||..|.|      |.:.:|    ||||.:     |:.|.|     
  Fly   672 QTTP---PQDESLDKGSQPGGKENSSITTIDPQAASEERQQRLLEQARR-----LILETRVKSGG 728

Human   395 --------RLER----LEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAF 447
                    :|||    :.:.||:|..:        :.|:..|.:....|..|::.:.|...:...
  Fly   729 SIESPTRPKLERTISPIHNGAEEFYAE--------HAKKLELKEPGSPSHRLSDPKVLQSFNAIV 785

Human   448 ESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLE 512
            |.....|:.|.::::.|..||                                 |||||.:   |
  Fly   786 ERVSPKHEKRGDKLSYIDSEL---------------------------------EALEREQ---E 814

Human   513 TIDQ--LHLEFAKRAA----PFNNWMEGAM-------------------------EDLQDMF--- 543
            .|||  .:||...||.    |.||...||.                         .|.:.:|   
  Fly   815 AIDQKASNLEAKLRAVMGGNPSNNRRGGARNSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGG 879

Human   544 -----------------------IVHSIEEIQSLI----TAHEQF-----KATL----------- 565
                                   :.:|.:|:.:.:    .:|..|     ::|:           
  Fly   880 AGSGGGRSGACSEDDDRDTSSDSVCNSGDELHTRLRPRPRSHSCFVNKNHQSTINTPAHLRPHHV 944

Human   566 -------------PEADGERQS----IMAIQNEVEKVIQSYNIRISS------------------ 595
                         |.|...:||    :.|..::.|.:..:.|.|.:|                  
  Fly   945 HHVVPYTHMLDSSPSALSSQQSSCDNLPACSDDDEVLAVAANGRAASLRRQQDRHRRRRQRRERR 1009

Human   596 -------SNPYSTVTMDELRTKWDKV--KQLVPIRDQ------SLQEELARQHA--NERLRRQFA 643
                   ::..:..|.::|.::|..:  |:...:|.|      ..:::|.|::.  |:.||   |
  Fly  1010 SHLCHTPNHCETEETEEQLLSQWFTLVNKKNALLRRQMQLNILEQEKDLERKYTMLNQELR---A 1071

Human   644 AQANAIGPW----IQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQE 704
            ||  ::..|    :|.:.|.:....:.   .:.|:.:||.|:.||                  ||
  Fly  1072 AQ--SVEDWRKTEVQREKERLLLEELM---TIVDKRDQLVQHLHN------------------QE 1113

Human   705 ALVFDNKHTNYTMEHIRVGWE 725
            ..:.|::.....:||:.:..|
  Fly  1114 IAIEDDQEIARKLEHVDISAE 1134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACTN2NP_001094.1 Actin-binding 1..254 47/137 (34%)
SAC6 36..>299 CDD:227401 57/189 (30%)
Spectrin 1 281..391 29/146 (20%)
Spectrin 281..391 CDD:306853 29/146 (20%)
Spectrin 2 401..506 17/104 (16%)
SPEC 402..629 CDD:238103 54/353 (15%)
Spectrin 3 516..627 32/237 (14%)
Spectrin 4 637..740 20/93 (22%)
Spectrin 637..739 CDD:306853 20/93 (22%)
EFh_PEF 747..>851 CDD:330173
EFhand_Ca_insen 824..890 CDD:312305
Ehbp1NP_995865.2 NT-C2 12..165 CDD:287345
CH 460..562 CDD:237981 39/102 (38%)
DUF3585 <1027..1122 CDD:288945 25/120 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0035
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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