DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACTN2 and Actn

DIOPT Version :9

Sequence 1:	NP_001094.1	Gene:	ACTN2 / 88	HGNCID:	164	Length:	894	Species:	Homo sapiens
Sequence 2:	NP_001259165.1	Gene:	Actn / 31166	FlyBaseID:	FBgn0000667	Length:	917	Species:	Drosophila melanogaster

Alignment Length:	918	Identity:	615/918 - (66%)
Similarity:	749/918 - (81%)	Gaps:	30/918 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     4 IEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRN 68
            :|.|:...|   .|.||.|||||:|:.||||||||||:||||||||||||||||.|:||||||||
  Fly     3 MENGLSMEY---GDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRN 64

Human    69 GLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGM 133
            ||||||||||||||.||||||||||||||||||||||:||||||.|||||||||||||:||||||
  Fly    65 GLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGM 129

Human   134 IWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLI 198
            |||||||||||||||||.:||||||||||||||||:|||:||||.|:||||..||||||||||||
  Fly   130 IWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLI 194

Human   199 DYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQ-- 261
            ||:||:||:|:.|:|.|.::|||:||||:|||.:|::||||||||||||||||:||||.||:|
  Fly   195 DYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVG 259

Human   262 --------------------AETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLEN 306
                                ||||||||||||.|||||||||||||||||:||||||||:|||.:
  Fly   260 NVTHVPEPTRQYTYVPNNYNAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNS 324

Human   307 RTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDI 371
            |..:.::..:|||||::|.||||||||:|::|.:||.||||||||||:|||||::|:|||.||||
  Fly   325 RQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDI 389

Human   372 AGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
            :.:|:.||.|||.:|||||.|..|||||||||:||:.||..||.|..|||::|..:|:....|.|
  Fly   390 SNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNE 454

Human   437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRR 501
            ::||.:|||||||||||||||||||||||||||.|:|||.|:||.|||:|||||||||.|||:||
  Fly   455 LKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRR 519

Human   502 EALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP 566
            .||:..|::||.||.|||||||||||||||::|..|||.||||||::||||.||.||:||||||.
  Fly   520 TALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLG 584

Human   567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
            |||.|...|:.:..|||.:::.:.|.....|||:|:|.:::..||..|:||||.|||:|..||.:
  Fly   585 EADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRK 649

Human   632 QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLE 696
            |..||.||||||.:||.:||||:.:|:.:....:.:.|:||||:::||:||..:..||.||::||
  Fly   650 QQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELE 714

Human   697 GDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761
            ..||.:||:::|:|::||||||.:|||||.|||:|.|.|||||.||||||:|||:|||:||||:|
  Fly   715 KIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSS 779

Human   762 FNHFDRRKNGLMDHEDFRACLISMGYDL-----GEAEFARIMTLVDPNGQGTVTFQSFIDFMTRE 821
            |||||:.:.|.:..|:|::||:|:||.:     |:.:|.||:.:||||..|.|.|.:|:||||||
  Fly   780 FNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRE 844

Human   822 TADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSS 886
            :.|||||||||.||||||:||||||.:|||||||||||:|||:|||.|.||..|||||||.:||:
  Fly   845 STDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFST 909

Human   887 ALYGESDL 894
            |||||:||
  Fly   910 ALYGETDL 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACTN2	NP_001094.1	Actin-binding	1..254		202/249 (81%)
		SAC6	36..>299	CDD:227401	226/284 (80%)
		Spectrin 1	281..391		74/109 (68%)
		Spectrin	281..391	CDD:306853	74/109 (68%)
		Spectrin 2	401..506		72/104 (69%)
		SPEC	402..629	CDD:238103	140/226 (62%)
		Spectrin 3	516..627		64/110 (58%)
		Spectrin 4	637..740		54/102 (53%)
		Spectrin	637..739	CDD:306853	53/101 (52%)
		EFh_PEF	747..>851	CDD:330173	64/108 (59%)
		EFhand_Ca_insen	824..890	CDD:312305	52/65 (80%)
Actn	NP_001259165.1	CH_ACTN_rpt1	31..135	CDD:409063	96/103 (93%)
		CH_ACTN_rpt2	139..252	CDD:409065	87/112 (78%)
		SPEC	302..525	CDD:238103	151/222 (68%)
		SPEC	420..647	CDD:238103	140/226 (62%)
		SPEC	538..760	CDD:238103	121/221 (55%)
		EFh	775..842	CDD:238008	31/66 (47%)
		EFhand_Ca_insen	847..913	CDD:400872	52/65 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I3072
eggNOG	1	0.900	-	-		E2759_KOG0035
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1288	1.000	Inparanoid score	I162
Isobase	1	0.950	-	0	Normalized mean entropy	S998
OMA	1	1.010	-	-		QHG54323
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	1	1.000	-	-		FOG0000815
OrthoInspector	1	1.000	-	-		otm41824
orthoMCL	1	0.900	-	-		OOG6_101135
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R34
SonicParanoid	1	1.000	-	-		X512
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820