Protein Alignment DYRK4 and mnb

DIOPT Version :10

• Sequence 1: NP_001358230.1
• Gene: DYRK4 / 8798
• HGNCID: 3095
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 169/443 - (38%)
• Similarity: 242/443 - (54%)
• Gaps: 72/443 - (16%)

Human   113 HNQMP--ASELKA--SEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEIL 173
            |:..|  :||::|  :.||.|           .:.|....:...:.:.:|.:|:
  Fly   207 HHSSPSSSSEVRAMQARIPNH-----------FREPASGPLRKLSVDLIKTYKH----------- 249

Human   174 GYAELWFLGLEAKKLDTAPE-------------KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETI 225
             ..|:::    |||...|.:             |.....:||::..|:....:....|||:...|
  Fly   250 -INEVYY----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLI 309

Human   226 GKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYF 290
            ||||||||.|..||:....||:|||:|||.|..||.:|:|:||.:.:.|.:|.|.:|.:|..|.:
  Fly   310 GKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMW 374

Human   291 RNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVL 353
            |||.|:.||||..|||:|::|.||:|.||::.|:|...:...|..||..:  |||||||||||:|
  Fly   375 RNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILL 439

Human   354 YQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPL 418
            ....::::|::||||||...|::|.||||||||||||:||..||:||||||||||..|::||.||
  Fly   440 CNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPL 504

Human   419 FPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFD------SKGFPKNITNNRGKKRYPDSKDL 477
            |.|.|||:|:..|:||||:||...:..|.:.:.|||      |....||  .|..|.:.|.|:.|
  Fly   505 FSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKN--QNGRKYKPPGSRKL 567

Human   478 TMVL---------KTYD---------TSFLDFLRRCLVWEPSLRMTPDQALKH 512
            ..:|         :..|         ..|.|.:.|.|.::|..|:||..||:|
  Fly   568 HDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQH 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK4	NP_001358230.1	PKc_DYRK4	175..515	CDD:271127	158/377 (42%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	150/334 (45%)