Protein Alignment DYRK4 and mnb

DIOPT Version :9

• Sequence 1: NP_001358230.1
• Gene: DYRK4 / 8798
• HGNCID: 3095
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 169/443 - (38%)
• Similarity: 242/443 - (54%)
• Gaps: 72/443 - (16%)

Human   113 HNQMP--ASELKA--SEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEIL 173
            |:..|  :||::|  :.||.|           .:.|....:...:.:.:|.:|:
  Fly   207 HHSSPSSSSEVRAMQARIPNH-----------FREPASGPLRKLSVDLIKTYKH----------- 249

Human   174 GYAELWFLGLEAKKLDTAPE-------------KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETI 225
             ..|:::    |||...|.:             |.....:||::..|:....:....|||:...|
  Fly   250 -INEVYY----AKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLI 309

Human   226 GKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYF 290
            ||||||||.|..||:....||:|||:|||.|..||.:|:|:||.:.:.|.:|.|.:|.:|..|.:
  Fly   310 GKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMW 374

Human   291 RNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVL 353
            |||.|:.||||..|||:|::|.||:|.||::.|:|...:...|..||..:  |||||||||||:|
  Fly   375 RNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILL 439

Human   354 YQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPL 418
            ....::::|::||||||...|::|.||||||||||||:||..||:||||||||||..|::||.||
  Fly   440 CNPKRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPL 504

Human   419 FPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFD------SKGFPKNITNNRGKKRYPDSKDL 477
            |.|.|||:|:..|:||||:||...:..|.:.:.|||      |....||  .|..|.:.|.|:.|
  Fly   505 FSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVLKKN--QNGRKYKPPGSRKL 567

Human   478 TMVL---------KTYD---------TSFLDFLRRCLVWEPSLRMTPDQALKH 512
            ..:|         :..|         ..|.|.:.|.|.::|..|:||..||:|
  Fly   568 HDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQH 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DYRK4	NP_001358230.1	PKc_DYRK4	175..515	CDD:271127	158/377 (42%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	150/334 (45%)
		S_TKc	303..623	CDD:214567	148/320 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850