DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DLK1 and dlk1

DIOPT Version :9

Sequence 1:	NP_003827.4	Gene:	DLK1 / 8788	HGNCID:	2907	Length:	383	Species:	Homo sapiens
Sequence 2:	XP_002936624.1	Gene:	dlk1 / 100494606	XenbaseID:	XB-GENE-988620	Length:	382	Species:	Xenopus tropicalis

Alignment Length:	373	Identity:	178/373 - (47%)
Similarity:	231/373 - (61%)	Gaps:	17/373 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH 65
            |..|.:.:..|.|.......|....|.|.|:|.|||||....|||:.||:|..||||:..|.|:|
Frog    11 MELTASCILCLFLSRFITTETKEIACMPGCHPVNGFCESQGECRCRTGWKGQFCDQCIPFPACMH 75

Human    66 GLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
            |.|.:|.||||.:||.|.|||.||..|::.||::|.||:...||.|.|.|:.||:||:|..|.||
Frog    76 GSCTKPWQCICEEGWVGSLCDIDVHPCAAKPCSSNSTCIETGDGGYICLCSLGYTGKNCLLKKGP 140

Human   131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIV--ANSCTPNPCENDGVCTDIGGDFR 193
            |..||||||:||.|.|:.|.||:|||.|||||.||:|||.  .:.|.||||.|.|.|||||..|.
Frog   141 CSTNGSPCQNGGKCTDNNGFASYASCQCPPGFIGNYCEIQIDIDDCNPNPCRNGGSCTDIGSGFH 205

Human   194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC-VKKRALSPQQVTR 257
            |.||.||..:.|:.....|:|:||.|||||.|..: .::|.|:|::||.|| ...|.:|.....|
Frog   206 CHCPLGFSGQFCNDLTPLCSSNPCANGGTCYQIGE-KFQCFCQPKYTGTTCSFPHRNMSLHLYER 269

Human   258 LPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKE-LNKKTPLLTEGQAICFTILGVLTSLVVLGT 321
            ..|        .|..|    :.|:|.:||:::|| :....|||.:.|.|||.:||:||.|:||.|
Frog   270 RNS--------LPSYH----KSPQHEVLKITVKETIQNVDPLLNKSQVICFIVLGLLTCLIVLIT 322

Human   322 VGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKI 369
            .||||.:|||||.:|.:|:.:||||||:.:|.:.|||..|.|||||.:
Frog   323 TGIVFFSKCETWFANAKYSRLLRKKKNIYMQRSRGEDRDVKIIFPEGV 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DLK1	NP_003827.4	EGF_CA	88..125	CDD:238011	17/36 (47%)
		EGF_CA	135..168	CDD:238011	22/32 (69%)
		EGF_CA	175..205	CDD:238011	17/29 (59%)
		EGF_CA	212..245	CDD:238011	17/33 (52%)
dlk1	XP_002936624.1	EGF_CA	98..134	CDD:238011	17/35 (49%)
		EGF_CA	143..178	CDD:238011	23/34 (68%)
		EGF_CA	182..217	CDD:238011	18/34 (53%)
		EGF	224..252	CDD:333761	13/28 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I28911
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2846
Inparanoid	1	1.050	383	1.000	Inparanoid score	I9332
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39048
OrthoDB	1	1.010	-	-		D148705at32523
OrthoFinder	1	1.000	-	-		FOG0012097
OrthoInspector	1	1.000	-	-		oto148774
Panther	1	1.100	-	-	LDO	PTHR24052
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10440
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080