Protein Alignment SIGLEC5 and CG45263

DIOPT Version :9

• Sequence 1: XP_016882908.1
• Gene: SIGLEC5 / 8778
• HGNCID: 10874
• Length: 560
• Species: Homo sapiens
• Sequence 2: NP_731246.2
• Gene: CG45263 / 50003
• FlyBaseID: FBgn0266801
• Length: 1876
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 134/574 - (23%)
• Similarity: 205/574 - (35%)
• Gaps: 132/574 - (22%)

Human    28 SVTVQEGLCVLVPCSFSYPWRSWYSSPPLYVYWF-RDGEI-PYYAEVVATNNPDRRVKPETQGRF 90
            ::|...|....|.|.      |.|.:||..:.|| .|.|| |.:.::.|| .||   .|.|....
  Fly   189 NITADAGALATVKCI------SHYGNPPATLKWFLGDQEISPIHPQMNAT-EPD---NPRTWSAT 243

Human    91 RLL---------GDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKP 146
            .::         ||:.:  |:     |..|...:....||...||||:        ....||..|
  Fly   244 SVVQVSAMRERHGDILR--CA-----AYHESYTAKSVVVEARLDVKYA--------PSIRLIGSP 293

Human   147 DIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRP---EDHG 208
            :|...|..::   ..|.|    ..:|.||.:..|.....|.:     .|.:.||..||   .|.|
  Fly   294 EIDLEEDKDA---LVLRC----VADANPPASIVWRRAGRSEI-----ASLQETLQLRPVGRRDAG 346

Human   209 TNLTCQMKRQGAQVTTER-TVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAP 272
            . .|||  .|.:..|:|: :|||:|.|.|:.|:...:.:        :..|:....|...|.|
  Fly   347 L-YTCQ--AQNSVGTSEQLSVQLDVKYPPKIISAGPDRL--------TTAPLFSPAAFECLAD-- 398

Human   273 SNPPAHLSWFQ----GSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPL-GFLQIFL----N 328
            .||.....|.|    ||..:.....|.   |.:..|....:|.:.|||...: |..::.:    :
  Fly   399 GNPLPSFKWVQRMAHGSKYVERGSESR---LVIDNVTYEYQGEYECRATSYINGQERVAISDPVS 460

Human   329 LSVYSLPQL--LGPSC------SWEAEGLH---CRCSFRARPAPS-LCWRLEEKPLEGNSSQGSF 381
            |.|...||:  |.||.      ..||..|.   |     |.|.|. :.|......||..|....|
  Fly   461 LQVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVC-----ADPRPQRVAWEWGSLRLEAGSGIDRF 520

Human   382 KVNSSSAGP----WANSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVP---- 438
            :.:......    :.::..|||..............|..|:...::.|:..    ||...|
  Fly   521 RADDMQPDTREDCYLSTLHILHADEHDSRPYYLVVENERGTDRHAIHLIVE----GTFAEPYEMS 581

Human   439 ---AALGGAGVMALLCICLCLIFFLICTVLVSFLRVKARR---KQAAGRPEKMDDEDPIMGTITS 497
               ...||.....||.:|||:            ..:|::|   |.:.|  .|..|:|.....:.|
  Fly   582 YLMGVAGGCMAAILLLVCLCI------------YAIKSKRCCFKGSTG--YKSSDKDSEKADLKS 632

Human   498 GSRKKPWPDSPGDQASPPG----DAPPLEEQKELHYASLSFSEM--KSREPKDQ 545
            .|.....|.......:|.|    .....::|::.|.|:.:.:.:  .|:.|:.|
  Fly   633 RSDSTSGPQGDSIYTTPAGFHHHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQ 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC5	XP_016882908.1	None
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845	25/99 (25%)
		IG_like	302..368	CDD:214653	23/80 (29%)
		IGc2	302..357	CDD:197706	18/69 (26%)
		Ig	372..446	CDD:299845	19/86 (22%)
		Ig	475..568	CDD:299845	18/97 (19%)
		IG_like	478..570	CDD:214653	18/96 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910