DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPDZ and Patj

DIOPT Version :9

Sequence 1:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	337/992 - (33%)
Similarity:	454/992 - (45%)	Gaps:	305/992 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     6 DKNRALHAAERLQTKLRERGD----VANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIAT 66
            |.:.||...|.::..:.|..|    :...:.||.:..:||.|:|..|:.:|.|:.:|..|:
  Fly     6 DISSALQQIEAVKKGIDESDDPKLQMQTAESLSTILGILQDPVFRTIVHVQDSLSELNAQL---- 66

Human    67 SATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQ 131
                                 .|:.|.|  ||:.::: :.|..:..:||.....:||:    ...
  Fly    67 ---------------------AQHPSML--PNDFDID-VAGNLVLSLNGGEVMYDFDE----QRS 103

Human   132 GRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196
            ..|..........|||:|...   |.:::...|..|.::.
  Fly   104 SSHSHSAPGSPDKSGGVGEEP---RPQSQNSKGAGVADLY------------------------- 140

Human   197 DQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELV 261
                           |.|..|:                                     :.||||
  Fly   141 ---------------ATDYAQI-------------------------------------QAIELV 153

Human   262 NDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG 326
            |||:||||||||.:.:||||||||||||||:.|||.||||||:|||.:|..|.|||||.||||.|
  Fly   154 NDGTGLGFGIIGARNSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMVSEQVAAVLRQSG 218

Human   327 NRVKLMIARG----------AIEERTA--PTAL-----------------GITLSSSPTSTPELR 362
            ..|:|::||.          |:|..||  ||.:                 .|...||..|||:..
  Fly   219 THVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQTT 283

Human   363 V--DASTQKGE------------------ESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFV 407
            .  |....:||                  |:|...|||.|:..|||||||||:.:|: |.|||||
  Fly   284 TEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKE-ELSGIFV 347

Human   408 KSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQE--- 467
            ||::..||.:..|||::.|:||.|||.:|||::|.||||:|:.:||.|.|.|.|  ||.|.|
  Fly   348 KSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQLQ 412

Human   468 -------------------AELMSREDVTKDADLSPVNASIIKENYEK----DEDFL-------- 501
                               |.:.:....|..|..:| :.||.:|..|:    .|.|:
  Fly   413 QAIAANDKLPSSAPGTPSRAPMPTPVATTSSATTTP-SRSITRELEEEALPAPEAFMTTPPSVTT 476

Human   502 --------------------SSTRNTNILPTEEEGYPLLS----------------AEIEEIEDA 530
                                |...:|.|:|||.  .||..                .:.|..:||
  Fly   477 MTTTTLSSFGAGKQLVAVRDSLDGSTKIIPTEV--VPLADKTEAKNSGVITRHKYYTDPELSDDA 539

Human   531 QKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVG---------HHFIRSVLPEGP 586
               |..::.|||:|:|.:.|::||.:.||:. .|||||||.||.         ||:|||:||:||
  Fly   540 ---ETEIIRKWQKIVGSDVEVIVAQIKKFAV-GGLGISLEGTVDVEGGREVRPHHYIRSILPDGP 600

Human   587 VGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRR---TVPPTTQSELDSLD- 647
            ||.:|.|.||||||||||..|||.||.:||.||||||::|.|||.|.   ::.|.:...|..|.
  Fly   601 VGVNGVLRSGDELLEVNGERLLGMNHLEVVAILKELPLDVRMVCGRNRNSSLLPFSDDTLKKLSN 665

Human   648 -------LCDIELTEKPHVDLGEFIGSSETEDPVLAMTDA-----GQSTEEVQAPLAMWEAGIQH 700
                   ..|..:..|....|.. .||....|.|.|...:     .:|.|.:.. ||||.:..|.
  Fly   666 NFENLLPATDRLVKAKSDGSLAT-AGSVADGDSVAAAAASFSKLKSRSLEPLTG-LAMWSSQPQI 728

Human   701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLE 765
            |||.||.:||||||||||||:||..|:|:||||||||:|:.||||:|||||:|||.:||||:||:
  Fly   729 IELVKGDRGLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQLDGRLIPGDRLLFVNSINLENASLD 793

Human   766 EAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGT 830
            :||:|||||..|.||||||||||::                                 |.:|...
  Fly   794 QAVQALKGASKGVVRIGVAKPLPMT---------------------------------DNSLKAC 825

Human   831 NDADLVDESTFESPYSP 847
            ::|....|.|.::..||
  Fly   826 SNASTTSEETLDAQPSP 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492
		L27_2	6..63	CDD:312549	17/60 (28%)
		PDZ_signaling	139..221	CDD:238492	10/81 (12%)
		PDZ_signaling	257..334	CDD:238492	55/76 (72%)
		PDZ	374..463	CDD:214570	49/90 (54%)
		PDZ_signaling	560..629	CDD:238492	46/77 (60%)
		PDZ_signaling	698..784	CDD:238492	61/85 (72%)
		PDZ_signaling	1006..1076	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140
		PDZ_signaling	1149..1240	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324
		PDZ	1347..1433	CDD:214570
		PDZ_signaling	1514..1593	CDD:238492
		MPDZ_u10	1595..1659	CDD:374710
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645
		PDZ	1660..1744	CDD:214570
		PDZ_signaling	1758..1836	CDD:238492
		PDZ_signaling	1893..1978	CDD:238492
Patj	NP_477342.1	L27	12..70	CDD:295425	15/82 (18%)
		PDZ_signaling	154..226	CDD:238492	51/71 (72%)
		PDZ_signaling	318..400	CDD:238492	46/82 (56%)
		PDZ_signaling	557..643	CDD:238492	50/86 (58%)
		PDZ_signaling	726..807	CDD:238492	57/80 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5351
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		otm40813
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4712
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800