DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPDZ and CG15803

DIOPT Version :9

Sequence 1:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	246/883 - (27%)
Similarity:	341/883 - (38%)	Gaps:	371/883 - (42%)

- Green bases have known domain annotations that are detailed below.

Human   252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 316
            |..:|.|:|:|||:||||.::||::|||::|.:.|||||::.|||..|||:|:||:.:|.|.|||
  Fly     7 WSQVEVIDLINDGNGLGFILVGGRSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRGFSSE 71

Human   317 QVAQVLRQCGNRVKLMIAR----GAIEERT-------APTAL----------------------- 347
            |||.||||.|.:|:|::||    .||:.:|       .||.|
  Fly    72 QVATVLRQTGAQVRLIVARPVEPTAIDYQTLACQAPIIPTKLLSDPEELSRHLFQNPSFATAAVA 136

Human   348 --------------------------------------GITLSS--------------------- 353
                                                  |..||:
  Fly   137 AAAAAAAAAGSGSDGDVGGGGVLDVASLVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGD 201

Human   354 -----------------------------------------SPTSTPELRV-------------- 363
                                                     ||...|.|::
  Fly   202 LADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQMLPLETQWRCVQDQN 266

Human   364 --------DA----------------------STQKGEESETFDVELTKNVQGLGITIAGYIGDK 398
                    |:                      |.....|:||:.|||.|||.|||||:|||:.::
  Fly   267 RHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKNVYGLGITVAGYVCEE 331

Human   399 KLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR-- 461
            : :.||||||||.:.||.|..|:|||.|:|:||||.:|.|.||.||||:||:|...|.|||.|
  Fly   332 E-DLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFL 395

Human   462 RGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLS--------STRNTNILPTEEEGYP 518
            ||.|.|...::..::...:..|.::.|     .:||:|..|        |....:.||.:.....
  Fly   396 RGRKYEHLQVALTEIKGTSAPSGLDRS-----QDKDQDQESQLSMPGSPSIATLSWLPPKSLDAD 455

Human   519 LLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIV-----------VAHVSKFSENSG-------- 564
            .::.|.:|..||:         :..|.|...|.:           ::||...|::||
  Fly   456 SIATEGDEAVDAE---------YVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLTKDQVP 511

Human   565 ----------------------------------------------------------------- 564

  Fly   512 RISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTDPDPDL 576

Human   565 ------------------------------LGISLEATVG---------HHFIRSVLPEGPVGHS 590
                                          ||||||.||.         ||:|||:|.:||||..
  Fly   577 DPGQMPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIRSILADGPVGRQ 641

Human   591 GKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
            |.|..|||||:||...|.|..|.:||.||||||..|.:||.|.|..|:.           |..::
  Fly   642 GILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKLVCARGTHVPSV-----------INTSQ 695

Human   656 KP------------HVDLGEFIGSSETEDPV-----LAMTDAG----------------QSTEEV 687
            .|            |..|...:..:::|..:     ..:||||                :|.|.|
  Fly   696 NPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTDAGAAAGGSGGTAGGGARSKSLENV 760

Human   688 QAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLM 752
            .. ||:|...:..:::||..:|.||||||||||:|...:||:||.|:.||.||....:.||||||
  Fly   761 SG-LALWSCEVTAVDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLM 824

Human   753 FVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLS 790
            .|.|..|:...|:|||..||..|.|..|:|:.:||..|
  Fly   825 SVGDRLLQGLELDEAVSILKAMPPGLTRLGICRPLSAS 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492
		L27_2	6..63	CDD:312549
		PDZ_signaling	139..221	CDD:238492
		PDZ_signaling	257..334	CDD:238492	44/76 (58%)
		PDZ	374..463	CDD:214570	53/90 (59%)
		PDZ_signaling	560..629	CDD:238492	42/180 (23%)
		PDZ_signaling	698..784	CDD:238492	42/85 (49%)
		PDZ_signaling	1006..1076	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140
		PDZ_signaling	1149..1240	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324
		PDZ	1347..1433	CDD:214570
		PDZ_signaling	1514..1593	CDD:238492
		MPDZ_u10	1595..1659	CDD:374710
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645
		PDZ	1660..1744	CDD:214570
		PDZ_signaling	1758..1836	CDD:238492
		PDZ_signaling	1893..1978	CDD:238492
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	42/71 (59%)
		PDZ	307..393	CDD:214570	52/86 (60%)
		PDZ_signaling	605..680	CDD:238492	39/74 (53%)
		PDZ	773..858	CDD:214570	42/84 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7709
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.770