DRSC/TRiP Functional Genomics Resources

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Protein Alignment MPDZ and CG5921

DIOPT Version :9

Sequence 1:NP_001362342.1 Gene:MPDZ / 8777 HGNCID:7208 Length:2103 Species:Homo sapiens
Sequence 2:NP_727061.2 Gene:CG5921 / 31538 FlyBaseID:FBgn0029835 Length:886 Species:Drosophila melanogaster


Alignment Length:1108 Identity:213/1108 - (19%)
Similarity:332/1108 - (29%) Gaps:384/1108 - (34%)


- Green bases have known domain annotations that are detailed below.


Human  1016 SSLGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSIN--------EESTISVTNAQAR 1071
            |:.|.||...:: |.|..|..:.|||.....| :.|||.||.||        .:..|.:...|.|
  Fly    83 STYGFTVRGGREHGTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQLVAGQDR 146

Human  1072 AMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEES 1136
            ..|:... :|. :.:..:|.|.|....:.|...||....    ||:.|          |..|...
  Fly   147 VTLKVRG-VGM-LPVRDLPEERLSWSVVKLPSVSGTPSE----SSFKG----------ERRGASR 195

Human  1137 ELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGT 1201
            ::.            |.|...|...||:.|..|         .|...|||::...:.|.|.:.| 
  Fly   196 DIS------------VVLHVAPRTKLGLGICKG---------PEWKPGIFVQFTKDRSVAREAG- 238

Human  1202 LKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSS 1266
            |:|||:|:.|:.:|..|....:|| |:.|:.:.:..:|::                         
  Fly   239 LRPGDQILSVNSIDFSDVLFSEAV-AVMKSSSKLDMVVRT------------------------- 277

Human  1267 TNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFG 1331
                                     |..|.:.|...|.:        .||||.::.|...     
  Fly   278 -------------------------AAGCDLFPGESSGY--------NSSASSVTGDQSP----- 304

Human  1332 YSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIAD 1396
             .|.:.:.:..|...|    |...|..|.|||.|....           .||.:.|         
  Fly   305 -CWADAKSKRLTAVRE----ESGAGGGGCGLSSAPGAG-----------SPNWSQG--------- 344

Human  1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQ--MAVCPGNAVEPLPSNSENLQN 1459
              :|::.|:                 :|..|....|..::|.  :|...|::|....|.......
  Fly   345 --VEVHKQM-----------------NKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSG 390

Human  1460 KELGYHRFSLYSKPRQSSSHLVYLCSQLIAVQLHLTEPTVTTSDAAVDLSSFKNVQHLELPKDQG 1524
            :.            :||.|:                     .|:.:.:.::.|. .||. |.:..
  Fly   391 RS------------QQSQSN---------------------PSNPSRNSTTMKR-SHLR-PVNSA 420

Human  1525 GLGIAISEEDTLS--------------GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1575
            |.||.:|.....|              |||..:......|..:|....|.          ||..:
  Fly   421 GSGIGLSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPPPAMNEGANASGS----------VGSSL 475

Human  1576 EKFIS-LLKTAKMTVKLTIHAE------------NPDSQAVPSAAGAASGEKKNSSQSLMVPQSG 1627
            ...|: .||..|...:...|.:            |.|.|        .:|...|......|.|  
  Fly   476 SSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVDRQ--------LTGHNGNGGHRSSVGQ-- 530

Human  1628 SPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEV 1692
                  :.:..|::...:.|:       :.|.|   .||....|.|....|||:...||      
  Fly   531 ------VSHRQRANVAGVAAT-------LQGSE---RISNLTGGGGAGGAGGSNGAAGA------ 573

Human  1693 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTL 1757
                         .|||             |...::..::..||    ::|:.....|.::....
  Fly   574 -------------GGDQ-------------HTALMDEFKRAHQR----MFRNGFHESEHKLSSLG 608

Human  1758 TIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGR-LMQGDQILMVNGEDVRNATQEAV 1821
            ...|..:...|..:|::..:|           ||....:|. :|...:.:.:....|..:|.:..
  Fly   609 KSSLADRSLYGREMSLLRVKN-----------GGSGGGEGSGVMPTMRPVSMGRPLVTMSTYQER 662

Human  1822 AALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLESSSKKNAL 1886
            ...||           |....|..|..|.|.:|..:           :|.|.:.|..:::..|.|
  Fly   663 GETLK-----------RTSIMPDESCYRNSINSNNN-----------NGFSRNRSNSNTNNNNRL 705

Human  1887 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTIC 1950
            .|:                .|::.|.|.||| |...|...|...|..:..|..|...|       
  Fly   706 QSQ----------------NGVNPANGNGSPELPPPPPQFANPQPKQMPPQHIKPMTG------- 747

Human  1951 GTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGP 2015
                         |...|.|||  ...:..|.::.|........|:|:|..|....:..|.|...
  Fly   748 -------------NAAANGSGS--ANGLGNGSLAKVRQPMSPMRSASISVGGFRPPATPQPDYDA 797

Human  2016 PQCKSITLERGPDG--------------LGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRL 2064
            .|.:|........|              ||...:|.||...  |......||   .|..:.:|.|
  Fly   798 VQIRSSQGSESVSGRDVATSQQQRRTLRLGTVTIGEYGDQRTTGKRETLRKT---NGEPASNGIL 859

Human  2065 KRG 2067
            |.|
  Fly   860 KNG 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MPDZNP_001362342.1 PDZ_signaling 2019..2102 CDD:238492 15/65 (23%)
L27_2 6..63 CDD:312549
PDZ_signaling 139..221 CDD:238492
PDZ_signaling 257..334 CDD:238492
PDZ 374..463 CDD:214570
PDZ_signaling 560..629 CDD:238492
PDZ_signaling 698..784 CDD:238492
PDZ_signaling 1006..1076 CDD:238492 22/68 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1140 2/18 (11%)
PDZ_signaling 1149..1240 CDD:238492 26/90 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1324 8/45 (18%)
PDZ 1347..1433 CDD:214570 15/85 (18%)
PDZ_signaling 1514..1593 CDD:238492 20/93 (22%)
MPDZ_u10 1595..1659 CDD:374710 9/75 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1645 6/44 (14%)
PDZ 1660..1744 CDD:214570 16/83 (19%)
PDZ_signaling 1758..1836 CDD:238492 12/78 (15%)
PDZ_signaling 1893..1978 CDD:238492 18/85 (21%)
CG5921NP_727061.2 PDZ_signaling 82..152 CDD:238492 22/69 (32%)
PDZ_signaling 197..276 CDD:238492 26/101 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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