DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPDZ and Mpdz

DIOPT Version :9

Sequence 1:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	2118	Identity:	1759/2118 - (83%)
Similarity:	1896/2118 - (89%)	Gaps:	65/2118 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIA 65
            |||.|||||||.||||||:||:||||||||||||||||||||||||||||||||:||||||||:|
  Rat     1 MLETIDKNRALQAAERLQSKLKERGDVANEDKLSLLKSVLQSPLFSQILSLQTSLQQLKDQVNVA 65

Human    66 TSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGI-PHINGKPACDEFDQLIKNM 129
            |.||:|.::||.|..|.|:|..||:||.||||:||||||::|||. |.::|||||:|.|||||:|
  Rat    66 TLATANADHAHTPQFSSAIISNLQSESLLLSPSNGNLEAISGPGAPPAMDGKPACEELDQLIKSM 130

Human   130 AQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
            |||||||:|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 AQGRHVEIFELLKPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 195

Human   195 ALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIE 259
            .||||||||||||||||||||:||||||||||.:.||.:|||||||||:||||||.||||:||||
  Rat   196 VLDQTITHQQAISILQKAKDTIQLVIARGSLPHISSPRISRSPSAASTVSAHSNPTHWQHVETIE 260

Human   260 LVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 LVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 325

Human   325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGI 389
            |||||||||||||:||..||::|||||||| |||.|:||||||||.|||||||||||||||||||
  Rat   326 CGNRVKLMIARGAVEETPAPSSLGITLSSS-TSTSEMRVDASTQKNEESETFDVELTKNVQGLGI 389

Human   390 TIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT 454
            ||||||||||||||||||||||||||||.||||||||||:|||||||||||||||||||||||||
  Rat   390 TIAGYIGDKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQT 454

Human   455 VLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPL 519
            |.|||||:|..||||:.||||..||.||.       .|||||||:.||..|:|:|||.|||||||
  Rat   455 VRLTLMRKGASQEAEITSREDTAKDVDLP-------AENYEKDEESLSLKRSTSILPIEEEGYPL 512

Human   520 LSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPE 584
            ||.|:||.||.| ||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   513 LSTELEETEDVQ-QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPE 576

Human   585 GPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLC 649
            |||||||||||||||||||||.||||||||||||||||||:|||||||||||||..||:||||:.
  Rat   577 GPVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPIDVTMVCCRRTVPPTALSEVDSLDIH 641

Human   650 DIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSI 714
            |:|||||||:||||||||||||||:|||:|..|:.||:|.||||||||||.|||||||:||||||
  Rat   642 DLELTEKPHIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGIQAIELEKGSRGLGFSI 706

Human   715 LDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTV 779
            ||||||||||:|||:||||||||||||||||.||||||||||:|||||:||||||||||||||.|
  Rat   707 LDYQDPIDPANTVIVIRSLVPGGIAEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMV 771

Human   780 RIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESP 844
            ||||||||||||||||||||||:||..||:|:|.||:||.||||||||:.|.||:.|.||.|||.
  Rat   772 RIGVAKPLPLSPEEGYVSAKEDTFLCSPHTCKEMGLSDKALFRADLALIDTPDAESVAESRFESQ 836

Human   845 YSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLL 909
            :||:|||:||||||:||||..:|.||:|||.|||||||||| .||.|.||.||:|||||||||||
  Rat   837 FSPDNDSVYSTQASVLSLHDGACSDGMNYGPSLPSSPPKDV-TNSSDLVLGLHLSLEELYTQNLL 900

Human   910 QRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDS 974
            |||...:|..|:|....||||::|||||||:||:|||.||:.||.|.|||. :|:.||...||..
  Rat   901 QRQHAGSPPTDMSPAATSGFTVSDYTPANAVEQKYECANTVAWTPSQLPSG-LSTTELAPALPAV 964

Human   975 AGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHG 1039
            |.|   ||.|||||..:||.|.||::|:|:||||:.||||:|||||||||||||||:||||||||
  Rat   965 APK---YLTEQSSLVSDAESVTLQSMSQEAFERTVTIAKGSSSLGMTVSANKDGLGVIVRSIIHG 1026

Human  1040 GAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIK--------------ITYVP 1090
            ||||||||||:||||||||||||||:||||||||||||||||||||              |||||
  Rat  1027 GAISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVP 1091

Human  1091 AEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELW 1155
            |||||||::|.|||:|.:||||||||||||||||||||||||||||||||.|||:|:||||||||
  Rat  1092 AEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELW 1156

Human  1156 REPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1157 REPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1221

Human  1221 HEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQS 1285
            ||||||||||||:|||||||||:|||||||||||.|:||||.:||||||||:|||:.:|||||||
  Rat  1222 HEQAVEAIRKAGSPVVFMVQSIVNRPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSDKAPSQS 1286

Human  1286 ESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHM 1350
            |||.|||.|||||...||.|:||.||:.|.||:.:::|.|||||||||||||:||||||||:|||
  Rat  1287 ESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVAEDEDKEDEFGYSWKNIQERYGTLTGQLHM 1351

Human  1351 IELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
            ||||||||||||||||||||:|||||||||||.||||:|||||||||||||||||||||||||||
  Rat  1352 IELEKGHSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNAS 1416

Human  1416 SIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKELGYHRFSLYSKPRQSSSHL 1480
            |||||||||||||||||.|||||||||||:|.:||||.||:.||||:
  Rat  1417 SIIKCAPSKVKIIFIRNADAVNQMAVCPGSAADPLPSTSESPQNKEV------------------ 1463

Human  1481 VYLCSQLIAVQLHLTEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLT 1545
                           ||::|||.:||||||..||.|||||||||||||||.|||||:||.|||||
  Rat  1464 ---------------EPSITTSASAVDLSSLTNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLT 1513

Human  1546 EHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAA 1610
            |.|.||.|||||.||:|||||||:|.|.|||||||||||||.|||||:.||||..|||||||..|
  Rat  1514 ERGGAAKDGRLKPGDRILAVDDELVAGCPIEKFISLLKTAKTTVKLTVGAENPGCQAVPSAAVTA 1578

Human  1611 SGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLS 1675
            |||:|:|||:..||   :|:.|.|.:||||||||||||||||||||||||||||||||:||||||
  Rat  1579 SGERKDSSQTPAVP---APDLEPIPSTSRSSTPAIFASDPATCPIIPGCETTIEISKGQTGLGLS 1640

Human  1676 IVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLT 1740
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1641 IVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLT 1705

Human  1741 LYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQI 1805
            |||||||||||:||||.|:||||:|||||||||||||||||||||||||||||||||||||||||
  Rat  1706 LYRDEAPYKEEDVCDTFTVELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQI 1770

Human  1806 LMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSG 1870
            ||||||||||||||||||||||||||||||||||||.||||||||||||||||.|||||:.|.||
  Rat  1771 LMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAAPFHSERRPSQSSQVSESSLSSFSLPRSG 1835

Human  1871 SSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAA 1935
            ..||||.|||:||||||||||||||||:||||.|:||:||||||||||||||||||||||.||||
  Rat  1836 IHTSESSESSAKKNALASEIQGLRTVEIKKGPADALGLSIAGGVGSPLGDVPIFIAMMHPNGVAA 1900

Human  1936 QTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSF 2000
            |||||||||||||||||||:||||||||||:||||||||:|||||||||||||||||.|:..|:|
  Rat  1901 QTQKLRVGDRIVTICGTSTDGMTHTQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQELANPCLAF 1965

Human  2001 TGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLK 2065
            ||||||:||.|||||||.|:|||:||||||||||||||||||||||||||||||||||:||||||
  Rat  1966 TGLTSSTIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAAEDGRLK 2030

Human  2066 RGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2103
            ||||||||||||||||||||||||||||||||||||||
  Rat  2031 RGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492	79/82 (96%)
		L27_2	6..63	CDD:312549	52/56 (93%)
		PDZ_signaling	139..221	CDD:238492	78/81 (96%)
		PDZ_signaling	257..334	CDD:238492	76/76 (100%)
		PDZ	374..463	CDD:214570	85/88 (97%)
		PDZ_signaling	560..629	CDD:238492	66/68 (97%)
		PDZ_signaling	698..784	CDD:238492	77/85 (91%)
		PDZ_signaling	1006..1076	CDD:238492	63/69 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140		18/18 (100%)
		PDZ_signaling	1149..1240	CDD:238492	89/90 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324		28/45 (62%)
		PDZ	1347..1433	CDD:214570	81/85 (95%)
		PDZ_signaling	1514..1593	CDD:238492	65/78 (83%)
		MPDZ_u10	1595..1659	CDD:374710	45/63 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645		27/44 (61%)
		PDZ	1660..1744	CDD:214570	82/83 (99%)
		PDZ_signaling	1758..1836	CDD:238492	75/77 (97%)
		PDZ_signaling	1893..1978	CDD:238492	76/84 (90%)
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611	52/56 (93%)
		PDZ_signaling	140..222	CDD:238492	78/81 (96%)
		PDZ_signaling	256..335	CDD:238492	77/78 (99%)
		PDZ	374..463	CDD:214570	85/88 (97%)
		PDZ_signaling	552..621	CDD:238492	66/68 (97%)
		PDZ_signaling	693..776	CDD:238492	75/82 (91%)
		PDZ_signaling	993..1063	CDD:238492	63/69 (91%)
		PDZ_signaling	1150..1241	CDD:238492	89/90 (99%)
		PDZ	1348..1433	CDD:214570	80/84 (95%)
		PDZ_signaling	1482..1561	CDD:238492	65/78 (83%)
		MPDZ_u10	1563..1624	CDD:293272	45/63 (71%)
		PDZ	1625..1709	CDD:214570	82/83 (99%)
		PDZ_signaling	1721..1801	CDD:238492	76/79 (96%)
		PDZ_signaling	1858..1943	CDD:238492	76/84 (90%)
		PDZ_signaling	1984..2067	CDD:238492	79/82 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83687275
Domainoid	1	1.000	289	1.000	Domainoid score	I16120
eggNOG	1	0.900	-	-		E1_KOG3528
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2841
Inparanoid	1	1.050	3429	1.000	Inparanoid score	I362
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51355
OrthoDB	1	1.010	-	-		D12016at7742
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		oto142770
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310