DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPDZ and mpdz

DIOPT Version :9

Sequence 1:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens
Sequence 2:	XP_002940172.2	Gene:	mpdz / 100488270	XenbaseID:	XB-GENE-994032	Length:	2164	Species:	Xenopus tropicalis

Alignment Length:	2246	Identity:	1428/2246 - (63%)
Similarity:	1640/2246 - (73%)	Gaps:	225/2246 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIA 65
            |||.||.:|||.|.||||.|:|||||:|||:||.|||||||||||:||||||||:|.|::|||:.
Frog     1 MLETIDTHRALQAVERLQVKVRERGDIANEEKLCLLKSVLQSPLFNQILSLQTSLQHLREQVNVT 65

Human    66 TSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNG----NLEALTGPGIPHINGKPACDEFDQLI 126
            .:.::..|:|.|.....:....|||||:.::..||    :.|..|.|..|.||||...:..:|:|
Frog    66 PALSTVSEFAQVSSYGSSTFSALQNESYSMAQQNGSPINSSETTTRPMSPQINGKLGSENLEQII 130

Human   127 KNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAI 191
            |.||||||:|..:||||.||.||||||||:||||||||||||||||.|||||||||||.||||:|
Frog   131 KQMAQGRHIETMDLLKPQSGSLGFSVVGLKSENRGELGIFVQEIQEDSVAHRDGRLKEADQILSI 195

Human   192 NGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHME 256
            |||.|||||||.|||.||||||:.||||||||.||||:||.:|||||.|||:||.|:|:||||:|
Frog   196 NGQPLDQTITHHQAIGILQKAKEQVQLVIARGPLPQLISPSISRSPSEASTVSALSSPMHWQHVE 260

Human   257 TIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQV 321
            |:|||||||||||||:|||:||||||||||||||||:||||||||||||||||||||||||||||
Frog   261 TVELVNDGSGLGFGIVGGKSTGVIVKTILPGGVADQNGRLCSGDHILKIGDTDLAGMSSEQVAQV 325

Human   322 LRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
            |||||.||||:||||.:|..:...:.|:.::.:..|..|.:|.....|..:.:.|||:||||.||
Frog   326 LRQCGKRVKLVIARGPVENSSTGVSTGVQITPALPSLLETQVCEGEIKDADGDAFDVKLTKNAQG 390

Human   387 LGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT 451
            ||||||||:|||..||||||||||||.||||.|||||:|||||.||||||:||||||||||||||
Frog   391 LGITIAGYVGDKGSEPSGIFVKSITKGSAVEQDGRIQVGDQIIVVDGTNLRGFTNQQAVEVLRHT 455

Human   452 GQTVLLTLMRRGMKQEAELMSREDVTK---------DADLSPVNASIIKENYEKDEDFLSSTRNT 507
            ||:|.|||:|||:||||.:...|:..|         :||.|.....||..::..|....|..
Frog   456 GQSVHLTLVRRGLKQEACIPQVEEPRKPTESGQPLQNADSSEACVPIIPTSFSSDAQSQSPA--- 517

Human   508 NILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
                    .:..|.||.|...|..:::  :.:|||||||:.||||||.|:||||:|||||||||:
Frog   518 --------NWSSLQAEKETQVDTDEED--IKSKWQRIMGVGYEIVVAKVNKFSESSGLGISLEAS 572

Human   573 VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPP 637
            .||||:||:|||||||.||.|:|||||||||||:|||:||.|||||||||||.||:||||:..||
Frog   573 GGHHFLRSILPEGPVGRSGSLYSGDELLEVNGISLLGQNHIDVVNILKELPICVTVVCCRQVKPP 637

Human   638 TTQSELDSLDLCDIELTE--------------------------------KPHVDLGEFIGSSET 670
            .:     |||..:..::|                                |.|:|.|..:|||||
Frog   638 NS-----SLDEKEQHISEQENDGPEGDFPVPLPALWKMQEDIPQSLDTDSKLHIDFGGTVGSSET 697

Human   671 EDPVLAMTDAGQSTEEVQ-APLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLV 734
            :|...|.|:.|||.|:.| :||||||..||.|.|||||.||||||||||||||||||||:|||||
Frog   698 DDLNTASTEDGQSIEDAQGSPLAMWETDIQDILLEKGSLGLGFSILDYQDPIDPASTVIVIRSLV 762

Human   735 PGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAK 799
            |||:||:||||||||||||||::|||::||||||:||||||:|.|.||||||||||||||.||||
Frog   763 PGGVAEQDGRLLPGDRLMFVNEINLEHASLEEAVQALKGAPTGNVSIGVAKPLPLSPEEGSVSAK 827

Human   800 EDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHG 864
            ||:..|...|..|.||:|.|||.|:||||.|.:.||..||..||.:|.::||.:  |||:|:|||
Frog   828 EDTLFYTAQSYAEEGLSDAPLFHAELALVETLEVDLTSESALESRFSAQDDSTF--QASLLALHG 890

Human   865 SSCGDGL-----------------NYGSSL---PSSPPKDVIEN----SCDPVLDLHMSLEELYT 905
            |:|.|.|                 .:.|.:   .||.||.:.|.    :..|:||..:.....|
Frog   891 SACNDDLTDEFLPKDVSEESFLDTTFNSEINTESSSFPKPLSEKELWATSTPMLDFKLPSINFY- 954

Human   906 QNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTE-SHLPSEVISSAELPS 969
             ||.:...:|:||.:          :.|:....|.|:|.:..:...|.. |....|:.:....|.
Frog   955 -NLEKENPKNSPSPE----------LKDHFERAAFEKQKDDVSPSSWINFSENSVEISADFTSPE 1008

Human   970 VLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVR 1034
            :..:....|.:||......:.||       :.|...|:.|::.:|:|||||||||:|||.|||||
Frog  1009 LKDEGFSSGKQYLETSEHSSANA-------LIKSKLEKIISVNRGSSSLGMTVSASKDGAGMIVR 1066

Human  1035 SIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIK-------------- 1085
            |||:||:|||||||::||||||||.|.|.::||||||||||||||:||||:
Frog  1067 SIINGGSISRDGRISVGDCILSINNECTANLTNAQARAMLRRHSLLGPDIRSSPAPADDQAPFYV 1131

Human  1086 ITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR 1150
            |||||:|||||::..|||.|......:|:.|.|...:||||||||||||||||:|..|||||.||
Frog  1132 ITYVPSEHLEEYRSCLGQPSEVKGTGEIYESNTESFVPELPEREEGEGEESELENATYSNWNNPR 1196

Human  1151 RVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMD 1215
            ||||||||.||||||||||||||||||||||||||||||:|||||||||||||.|||||||||.|
Frog  1197 RVELWREPGKSLGISIVGGRGMGSRLSNGEVMRGIFIKHILEDSPAGKNGTLKTGDRIVEVDGTD 1261

Human  1216 LRDASHEQAVEAIRKAGNPVVFMVQSIINRPR----------------------------KSPLP 1252
            ||||||||||||||||||||||:|||||||||                            |..||
Frog  1262 LRDASHEQAVEAIRKAGNPVVFLVQSIINRPRPESVYCSPSSSALRQHPTTNPFSHPSPKKPALP 1326

Human  1253 SLLHNLYPKYNFSSTNPFADSLQINAD------------------------KAPSQSESEPEKAP 1293
            .|......|..|..|||| ||.|:|.:                        ||.|.|:||.||..
Frog  1327 LLQSTFGTKPLFRCTNPF-DSSQLNINKGTMNPVRIAFRCSPTNPFAPTPFKASSSSDSETEKTS 1390

Human  1294 LCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS 1358
             .|.....||..:.:.|:..|.::   |.|.:||||||||||.|.:|||.|.|||||||||||.:
Frog  1391 -SSNYLTGPSTLSSVNSEKLQMTS---STDPEKEDEFGYSWKKISQRYGNLPGELHMIELEKGKT 1451

Human  1359 GLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS 1423
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1452 GLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS 1516

Human  1424 KVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKELGYHRFSLYSKPRQSSSHLVYLCSQLI 1488
            ||||||||||||||||||||..|.||...||....|
Frog  1517 KVKIIFIRNKDAVNQMAVCPVKATEPSFPNSSAFSN----------------------------- 1552

Human  1489 AVQLHLTEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATD 1553
               |.:.|.:|.:....:::.|||||.|:||||||||||||||||||::||:|||||:||.||.|
Frog  1553 ---LEVEEESVPSPVLPLNVGSFKNVLHVELPKDQGGLGIAISEEDTVNGVVIKSLTDHGAAAKD 1614

Human  1554 GRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPD-SQAVPSAA---GAASGEK 1614
            ||:||||.|||||||.|||.||||.|.|||.||.||||||.::..| .|.:|..:   .:::||.
Frog  1615 GRIKVGDCILAVDDEPVVGDPIEKVICLLKKAKTTVKLTISSDEKDMPQLLPLPSITLTSSTGEI 1679

Human  1615 KNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG 1679
            ||..|.|  |.|...|||.:|::|||||||.|.||||||||||||||||:|||||||||||||||
Frog  1680 KNGQQCL--PLSNFSEPEPVRSSSRSSTPATFPSDPATCPIIPGCETTIDISKGRTGLGLSIVGG 1742

Human  1680 SDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRD 1744
            :||||||||||||||||||.||||||||||||||||||||.|||||||||||||||:||||:|||
Frog  1743 ADTLLGAIIIHEVYEEGAASKDGRLWAGDQILEVNGIDLRNATHDEAINVLRQTPQKVRLTVYRD 1807

Human  1745 EAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVN 1809
            ||.||||::.|.|.:||||||||||||||||||||||||||||||||||:.|||||||||:||||
Frog  1808 EAQYKEEDMYDVLDLELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIAEIDGRLMQGDQLLMVN 1872

Human  1810 GEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEG--SLSSFTFPLSGSS 1872
            |||||||||||||||||||||||.|||||||.||||||||.|||||||||  ||:||:||:.|.:
Frog  1873 GEDVRNATQEAVAALLKCSLGTVKLEVGRIKTGPFHSERRTSQSSQVSEGTSSLTSFSFPMPGPA 1937

Human  1873 TSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQT 1937
            .:   :|.|||:. .||||||||||:|||||||||||||||||||||||||||||||..||||||
Frog  1938 AA---DSGSKKSD-TSEIQGLRTVEIKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHANGVAAQT 1998

Human  1938 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTG 2002
            .|||||||||:|||..||||||:|||.|||||||:||:|||||||||||||.|||...|::||:|
Frog  1999 HKLRVGDRIVSICGQPTEGMTHSQAVTLLKNASGTIELQVVAGGDVSVVTGQQQEHLGSTVSFSG 2063

Human  2003 LTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRG 2067
            |.||||.||||||||.|:|.|||||||||||||||:|||||||||||||||:||||||||||.||
Frog  2064 LASSSILQDDLGPPQYKTIILERGPDGLGFSIVGGHGSPHGDLPIYVKTVFSKGAASEDGRLNRG 2128

Human  2068 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2103
            ||||||||||||||||||||:|||||||||||.|||
Frog  2129 DQIIAVNGQSLEGVTHEEAVSILKRTKGTVTLTVLS 2164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492	75/82 (91%)
		L27_2	6..63	CDD:312549	42/56 (75%)
		PDZ_signaling	139..221	CDD:238492	69/81 (85%)
		PDZ_signaling	257..334	CDD:238492	70/76 (92%)
		PDZ	374..463	CDD:214570	73/88 (83%)
		PDZ_signaling	560..629	CDD:238492	56/68 (82%)
		PDZ_signaling	698..784	CDD:238492	71/85 (84%)
		PDZ_signaling	1006..1076	CDD:238492	51/69 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140		16/18 (89%)
		PDZ_signaling	1149..1240	CDD:238492	85/90 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324		14/69 (20%)
		PDZ	1347..1433	CDD:214570	83/85 (98%)
		PDZ_signaling	1514..1593	CDD:238492	62/78 (79%)
		MPDZ_u10	1595..1659	CDD:374710	33/67 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645		20/47 (43%)
		PDZ	1660..1744	CDD:214570	77/83 (93%)
		PDZ_signaling	1758..1836	CDD:238492	71/77 (92%)
		PDZ_signaling	1893..1978	CDD:238492	73/84 (87%)
mpdz	XP_002940172.2	L27_2	6..63	CDD:312549	42/56 (75%)
		PDZ_signaling	139..225	CDD:238492	70/85 (82%)
		PDZ_signaling	259..338	CDD:238492	71/78 (91%)
		PDZ	380..467	CDD:214570	73/86 (85%)
		PDZ_signaling	560..629	CDD:238492	56/68 (82%)
		PDZ	726..814	CDD:214570	73/87 (84%)
		PDZ	1038..1108	CDD:214570	51/69 (74%)
		PDZ_signaling	1195..1286	CDD:238492	85/90 (94%)
		PDZ	1440..1526	CDD:214570	83/85 (98%)
		PDZ	1574..1657	CDD:214570	65/82 (79%)
		MPDZ_u10	1662..1722	CDD:374710	32/61 (52%)
		PDZ	1723..1807	CDD:214570	77/83 (93%)
		PDZ_signaling	1819..1899	CDD:238492	72/79 (91%)
		PDZ_signaling	1954..2039	CDD:238492	73/84 (87%)
		PDZ_signaling	2080..2163	CDD:238492	75/82 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I20957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2841
Inparanoid	1	1.050	2575	1.000	Inparanoid score	I364
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51355
OrthoDB	1	1.010	-	-		D12016at7742
OrthoFinder	1	1.000	-	-		FOG0003499
OrthoInspector	1	1.000	-	-		oto158534
Panther	1	1.100	-	-	LDO	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1763
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080