Protein Alignment PABPC4 and Sxl

DIOPT Version :10

• Sequence 1: NP_001129125.1
• Gene: PABPC4 / 8761
• HGNCID: 8557
• Length: 660
• Species: Homo sapiens
• Sequence 2: NP_001259303.1
• Gene: Sxl / 3772180
• FlyBaseID: FBgn0264270
• Length: 722
• Species: Drosophila melanogaster
• Alignment Length: 480
• Identity: 111/480 - (23%)
• Similarity: 175/480 - (36%)
• Gaps: 134/480 - (27%)

Human   191 TNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRD-PNGKSKGFGFVSYEKHEDANKAVEEMNGK 254
            ||:.:....:::.|..|..||...|...:.::||| ..|.|.|:.||.:....|:.:|::.:||.
  Fly   117 TNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRAIKVLNGI 181

Human   255 EISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKNLDDTIDDEKLRKEFSPFGS 319
            .:               |...||..:.:...|.|   :..|||:.||..||.|::|...|..:||
  Fly   182 TV---------------RNKRLKVSYARPGGESI---KDTNLYVTNLPRTITDDQLDTIFGKYGS 228

Human   320 ITSAKVMLE--DGRSKGFGFVCFSSPEEATKAVTEMNGRIV--GSKPLYVALAQRKEERK-AHLT 379
            |....::.:  .||.:|..||.::..|||.:|::.:|..|.  ||:||.|.||:...:.| ||..
  Fly   229 IVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRLAEEHGKAKAAHFM 293

Human   380 NQYMQRVAGMRALPANAILNQFQPAA---------------------------------GGYFVP 411
            :|       |..:|||......||.|                                 ...|..
  Fly   294 SQ-------MGVVPANVPPPPPQPPAHMAAAFNMMHRDGAMEKLRSLFDAICDAIFGLDSENFAD 351

Human   412 AVPQAQGRPPYY-----TPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGNA 471
            .:.....|..:|     ||.|..|:..:        .|...|..|:...|         ...||.
  Fly   352 LLDGLYRRKYHYPYLXLTPQQQQQLLQH--------QQQALGFTSSSNNS---------IGNGNG 399

Human   472 PASRGL---------PTTTQRVGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAA 527
            ..:..|         .|..||:|:.....::.:    |:.....|.:..:....|..||     .
  Fly   400 NDNNMLLYHQQYHQQQTQQQRLGNVAAHNISPN----GSNNNINTSNTNNINFNTIRQN-----G 455

Human   528 VAAAAPRAVAPYKYASSVRSPHPAIQPLQAPQPA-VHVQGQEPLTASMLAAAPPQEQKQMLGERL 591
            |||.                 |...:.||..||. ...|.|:|||   :.::||.:|:..
  Fly   456 VAAL-----------------HYLQEQLQLQQPQDQQSQQQQPLT---MPSSPPFQQQSR----- 495

Human   592 FPLIQTMHSNLAGKITGMLLEIDNS 616
                |:.|:..:..:...||.|.|:
  Fly   496 ----QSHHNGSSSTLGNQLLAISNN 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPC4	NP_001129125.1	PABP-1234	11..640	CDD:130689	111/480 (23%)
Sxl	NP_001259303.1	sex-lethal	16..297	CDD:273740	59/204 (29%)