DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDS2 and Cds

DIOPT Version :9

Sequence 1:	NP_003809.1	Gene:	CDS2 / 8760	HGNCID:	1801	Length:	445	Species:	Homo sapiens
Sequence 2:	NP_001286976.1	Gene:	Cds / 43950	FlyBaseID:	FBgn0010350	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	267/456 - (58%)
Similarity:	332/456 - (72%)	Gaps:	26/456 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTELRQRVAHEPVAPPEDKE-SESEAKVDGETASDS----ESRAESAP-----------LPVSAD 49
            |.|:|:|...:  .|.||.. |.|:|.....:|:||    :|..|..|           ||...|
  Fly     1 MAEVRRRKGED--EPLEDTAISGSDAANKRNSAADSSDHVDSEEEKIPEEKFVDELAKNLPQGTD 63

Human    50 DTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGY 114
            .|||:|:.||.:|..|||||.:|||.|..||..|.:|||.||:.|||..:.||:|||.|||:|||
  Fly    64 KTPEILDSALKDLPDRWKNWVIRGIFTWIMICGFALIIYGGPLALMITTLLVQVKCFQEIISIGY 128

Human   115 NVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFC 179
            .||..:.|||||:|||||||..|||||||.:.|||..::.|.|.|:.|..||||:||.||:|||.
  Fly   129 QVYRIHGLPWFRSLSWYFLLTSNYFFYGENLVDYFGVVINRVEYLKFLVTYHRFLSFALYIIGFV 193

Human   180 MFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGF 244
            .||||||||:|..||.:|.||||:||||||||:|:|.|:|||:||||||:|.::|||:|||:|||
  Fly   194 WFVLSLVKKYYIKQFSLFAWTHVSLLIVVTQSYLIIQNIFEGLIWFIVPVSMIVCNDVMAYVFGF 258

Human   245 FFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDL 309
            ||||||||||||||||||||||.||||:||:|.|||:..|:.|:||::|:.:....|:.|.||.|
  Fly   259 FFGRTPLIKLSPKKTWEGFIGGGFATVLFGILFSYVLCNYQYFICPIQYSEEQGRMTMSCVPSYL 323

Human   310 FRLQEYNIPGVIQSVIG-WKTVRMYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTI 373
            |..|||::     .:.| .||:.:|||..|||:||.|:|:|||||||||||||||||||||.:.|
  Fly   324 FTPQEYSL-----KLFGIGKTLNLYPFIWHSISLSLFSSIIGPFGGFFASGFKRAFKIKDFGDMI 383

Human   374 PGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLRSHLIDKGML 438
            |||||||||||||:||||||||||:||||.|:|:||:.|...|:||||..|:.:|:.:|.|  ||
  Fly   384 PGHGGIMDRFDCQFLMATFVNVYISSFIRTPSPAKLLTQIYNLKPDQQYQIYQSLKDNLGD--ML 446

Human   439 T 439
            |
  Fly   447 T 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDS2	NP_003809.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		18/63 (29%)
CDS2	NP_003809.1	CTP_transf_1	106..425	CDD:304393	210/319 (66%)
Cds	NP_001286976.1	CTP_transf_1	120..438	CDD:304393	211/322 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155356
Domainoid	1	1.000	462	1.000	Domainoid score	I482
eggNOG	1	0.900	-	-		E1_COG0575
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1216
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54574
OrthoDB	1	1.010	-	-		D1072976at2759
OrthoFinder	1	1.000	-	-		FOG0001281
OrthoInspector	1	1.000	-	-		otm41620
orthoMCL	1	0.900	-	-		OOG6_101561
Panther	1	1.100	-	-	O	PTHR13773
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2065
SonicParanoid	1	1.000	-	-		X636
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800