Protein Alignment ADAM18 and Kul

DIOPT Version :10

• Sequence 1: NP_055052.1
• Gene: ADAM18 / 8749
• HGNCID: 196
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_651716.1
• Gene: Kul / 43501
• FlyBaseID: FBgn0039688
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 692
• Identity: 156/692 - (22%)
• Similarity: 234/692 - (33%)
• Gaps: 231/692 - (33%)

Human    35 SNDSEVSERKMIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAA 99
            :|:|..:.||:          ||.|        :|.:|.|||     ..:.|.|       |...
  Fly   341 NNNSNNNVRKL----------YTKH--------KNIIVSTYN-----RPIEPEF-------GTPY 375

Human   100 EFPNSFVTLSICSGLRG----FLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYS-H 159
            |.||:..|..:.|....    .|...|.:.|.:........|.|........||  |:..||: .
  Fly   376 EEPNNNGTRELPSNFFNANWTTLFLGNNNNGNDRPSHKTHVEIITKNGATKKPN--IIVNNYNPE 438

Human   160 IWQKDQPYKVPLNSQIKNLSKLL-----------PQYL-------EIYIIVEKALYDYMGSEMMA 206
            |.....|:....||.:  ::.||           |:.|       .:|:..:...:..|||:..:
  Fly   439 IIFAPNPHNPSFNSMM--MTNLLSGRGGEDIHSSPRLLYDRKTTCMLYLQADHTFFQKMGSDEAS 501

Human   207 VTQKIVQVIGLVNTMF--TQF-------KLTVILSSLELWSNENQISTSGDADDILQRF------ 256
            : :.|.:.:...||::  |.|       .:|.::..::: .|.|.:.      |...||
  Fly   502 I-EAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKV-HNMNAMK------DPSYRFPGNYGV 558

Human   257 -----LAWKRDYLILRPHD---IAYLLVYRKHPK-YVGATFPGTVCN---------------KSY 297
                 |..:.||      |   :||:..||.... .:|..:.|.:.|               ||.
  Fly   559 EKFLELFSEEDY------DAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSL 617

Human   298 DAGIAM-------YPDAIGLEGFSVIIAQLLGLNVGLTYDDITQC--------FCL--RATCIMN 345
            :.||..       .|.|:.    .|.:|..:|.|.|..:|. .||        |.:  |||
  Fly   618 NTGIVTLLNYGKHVPPAVS----HVTLAHEIGHNFGSPHDP-EQCTPGGEDGNFIMFARAT---- 673

Human   346 HEAVSASGRK----IFSNCSMHDYRYFVSKFETKCLQKLSNLQP-------LHQNQPVCGNGILE 399
                  ||.|    .||.||:            |.::.:.|.:.       ......:||||::|
  Fly   674 ------SGDKKNNNKFSTCSL------------KSIEPVLNAKARSMKGCFTEPQSSICGNGVVE 720

Human   400 SNEECDCGNKNECQFKKCC---------DYNTCKLKGSVKC--GSGPCCTSKCELSIAGTPCRKS 453
            ..|:||||.:.:|: ..||         |...|.|....:|  ..|||||:.|:|.. |..||.
  Fly   721 PGEQCDCGWEEDCK-DSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKF-GDKCRD- 782

Human   454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACF 518
             |..|....:|:|....|.|.....|..:|. ....||.|.|  |.:.|...
  Fly   783 -DNGCRDPSFCDGRVPQCPPSVNKPNKTICN-KEFVCYMGDC--TGSICLAY------------- 830

Human   519 KEVNSLHERSENCGFKNSQPLPCERKDVL--CGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSI 581
                         |.::.|.:|..:.|.:  | :|.|..|.                :|..|.|.
  Fly   831 -------------GLESCQCIPGPQDDRIKSC-ELCCKLPG----------------EDSPCRSS 865

Human   582 ATGSSMRSDGTDNAYVADGTMCGP-EMYC-VNKTCRKVHLMG 621
            ...:....|..| .|...||.|.. ..|| |.:.||:|...|
  Fly   866 FEWNEAPFDVPD-MYSKPGTPCNDYNGYCDVFQKCREVDPSG 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM18	NP_055052.1	Pep_M12B_propep	27..141	CDD:460254	25/109 (23%)
		ZnMc_adamalysin_II_like	184..378	CDD:239797	53/260 (20%)
		DISIN	399..476	CDD:214490	29/87 (33%)
		ACR	478..617	CDD:214743	30/142 (21%)
Kul	NP_651716.1	Pep_M12B_propep	70..186	CDD:460254
		ZnMc_TACE_like	479..713	CDD:239798	53/274 (19%)
		Disintegrin	720..801	CDD:459709	28/84 (33%)