Protein Alignment ADAM18 and mmd

DIOPT Version :10

• Sequence 1: NP_055052.1
• Gene: ADAM18 / 8749
• HGNCID: 196
• Length: 739
• Species: Homo sapiens
• Sequence 2: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Alignment Length: 677
• Identity: 188/677 - (27%)
• Similarity: 280/677 - (41%)
• Gaps: 133/677 - (19%)

Human    58 LHLGKQSFLP----QNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFL 118
            |.|..|...|    :::.|..|...|:.|.:.     ||:|.|...::|.:......|:|:.|.:
  Fly   130 LELNSQLLSPNIQQKHYHVGGYLVDGNRHDIE-----HCYYHGTVKDYPGASAAFHTCNGVSGVI 189

Human   119 QFENISYGIEPVESS--ARFEHIIYQMKN-------NDPNVSILAVNYSHIWQKDQPYKVPLNSQ 174
            ...|.::.|.|....  ::..|:|::.:.       |..|:.        .|:        |:.:
  Fly   190 HIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLD--------SWR--------LSRR 238

Human   175 IKNLS----------------------KLLPQYLEIYIIVEKALYDYM-GSEMMAVTQKIVQVIG 216
            .|:||                      :...:|:|..|||:||::|.. ||....|....:||..
  Fly   239 TKHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQVAN 303

Human   217 LVNTMFTQFKLTVILSSLELW-SNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKH 280
            :.:..|......|.:..:|.| .|:..|..|.|....:..|..:....|.....|...||
  Fly   304 IADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNLFQIERDTTQLL----- 363

Human   281 PKYVGATFPGTVCNKSYDAGIAM-----YPDAIGLEGFSV------------IIAQLLGLNVGLT 328
               .|.||.|.      :||:|:     .|.|:|:   ||            .:|.::|.|:|:.
  Fly   364 ---TGETFAGG------EAGMAVPETVCTPRAVGI---SVDVNVYEPHLLAGTMAHMIGHNIGMG 416

Human   329 YDD-ITQCF------CLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPL 386
            :|| ..:||      |:.|..|:..|.|....   ||.||..||...:......||....|...|
  Fly   417 HDDGREECFCRDWHGCIMAQSIVGQENVQPYK---FSECSKKDYIDALRTGHGLCLLNKPNEIEL 478

Human   387 HQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCR 451
            .:|   |||.::|.:||||||...||...:|||..|||||...:|.||.|| .:|.|......||
  Fly   479 RRN---CGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACC-DQCRLRPKDYICR 539

Human   452 KSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG----TAYCYNGQCQTTDNQCAKIFGKGAQG 512
            .| :.|||..|||:|....|..|.:..||..|.|.    :.||:.|.|.|...||..|:|.|...
  Fly   540 DS-NNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSA 603

Human   513 APFACFKEVNSLHERSENCG-FKNSQPLPCERKDVLCGKLACVQPHKNANK---SDAQSTVYSYI 573
            |...|:::.||....:.:|| ..|...:.||.::|.||.|.|    |:..:   :|....:||..
  Fly   604 ADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQC----KDGERQPVNDGIDQLYSRT 664

Human   574 ------QDHVCVSIATGSSMRSDG-TDNAYVADGTMCGPEMYCVNKTCRKV--HLMGYNCNATT- 628
                  |:..|.  ||...:.|:. .::..|.|||.||..:.|:|:||..:  |:....|.|.:
  Fly   665 IISIKGQEFECK--ATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQ 727

Human   629 --KCKGKGICNNFGNCQCFPGHRPPDC 653
              :|...|:|.|...|.|..|....||
  Fly   728 GLECSEHGVCTNTNRCFCDMGWGGNDC 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM18	NP_055052.1	Pep_M12B_propep	27..141	CDD:460254	20/88 (23%)
		ZnMc_adamalysin_II_like	184..378	CDD:239797	58/219 (26%)
		DISIN	399..476	CDD:214490	36/76 (47%)
		ACR	478..617	CDD:214743	47/153 (31%)
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	20/88 (23%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/220 (27%)
		Disintegrin	488..561	CDD:459709	35/74 (47%)
		ACR	566..713	CDD:214743	47/152 (31%)