DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADAM21 and Kul

DIOPT Version :10

Sequence 1:NP_003804.2 Gene:ADAM21 / 8747 HGNCID:200 Length:722 Species:Homo sapiens
Sequence 2:NP_651716.1 Gene:Kul / 43501 FlyBaseID:FBgn0039688 Length:1537 Species:Drosophila melanogaster


Alignment Length:437 Identity:108/437 - (24%)
Similarity:151/437 - (34%) Gaps:147/437 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   217 NHDFFIYSQSNISKVQEDVFLVVNI--------VDSMYKQLGTYIILIGIEIWNQGNVFPMTSIE 273
            |.||     :|..|.....|::..|        .|..|:..|.|                  .:|
  Fly   518 NTDF-----NNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGNY------------------GVE 559

Human   274 QVLNDFSQWKQISLSQLQHDA---AHMF-IKNSLISILGLAY------VAGICRPPIDCGVDNFQ 328
            :.|..|        |:..:||   |:|| .::..:..||||:      ..|:|...     .:::
  Fly   560 KFLELF--------SEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKN-----GHYR 611

Human   329 GDTWSLFAN------------------TVAHELGHTLGMQHDEEFCF-CGERGCIMNTFRVPA-- 372
            |...||...                  |:|||:||..|..||.|.|. .||.|..:...|..:  
  Fly   612 GSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGD 676

Human   373 ----EKFTNCSYADFMKTTLN-----QGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQC 428
                .||:.||... ::..||     ...|...|       ....|||||||..||||||..:.|
  Fly   677 KKNNNKFSTCSLKS-IEPVLNAKARSMKGCFTEP-------QSSICGNGVVEPGEQCDCGWEEDC 733

Human   429 EQDACCL----------LNCTLRPGAAC--AFGLCC-KDCKFMPSGELCRQEVNECDLPEWCNGT 480
             :|:||.          ..|||.|.|.|  :.|.|| .||| :..|:.||.: |.|..|.:|:|.
  Fly   734 -KDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCK-LKFGDKCRDD-NGCRDPSFCDGR 795

Human   481 SHQCPEDRYVQDGIPCSDSAYCYQKRCN---------------------------------NHDQ 512
            ..|||......:...|:....||...|.                                 ..|.
  Fly   796 VPQCPPSVNKPNKTICNKEFVCYMGDCTGSICLAYGLESCQCIPGPQDDRIKSCELCCKLPGEDS 860

Human   513 HCREIF-GKDAKSASQNCYKEINSQGNRF-GHCGINGTTYLKCHISD 557
            .||..| ..:|.....:.|.:..:..|.: |:|.:    :.||...|
  Fly   861 PCRSSFEWNEAPFDVPDMYSKPGTPCNDYNGYCDV----FQKCREVD 903

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADAM21NP_003804.2 Pep_M12B_propep 41..159 CDD:460254
Cysteine switch. /evidence=ECO:0000250 171..178
ZnMc_adamalysin_II_like 208..396 CDD:239797 51/226 (23%)
Disintegrin 415..487 CDD:459709 34/84 (40%)
ACR 491..627 CDD:214743 16/102 (16%)
KulNP_651716.1 Pep_M12B_propep 70..186 CDD:460254
ZnMc_TACE_like 479..713 CDD:239798 52/238 (22%)
Disintegrin 720..801 CDD:459709 33/83 (40%)
Blue background indicates that the domain is not in the aligned region.

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