Protein Alignment ADAM21 and mmd

DIOPT Version :10

• Sequence 1: NP_003804.2
• Gene: ADAM21 / 8747
• HGNCID: 200
• Length: 722
• Species: Homo sapiens
• Sequence 2: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 200/683 - (29%)
• Similarity: 309/683 - (45%)
• Gaps: 102/683 - (14%)

Human    50 SRGRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDDRALLEDQLFIPDDCYYHGY 114
            :|||:.|.....|..::....|..:.:.:...|:|.::....|.....|::......:.|||||.
  Fly   104 NRGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGT 168

Human   115 VEAAPESLVVFSACFGGFRGVLKISGLTYEIEPI------RHSATFEHLVY----KIN---SNET 166
            |:..|.:...|..| .|..||:.|...|:.|.|.      :|    .|:::    |.|   :|..
  Fly   169 VKDYPGASAAFHTC-NGVSGVIHIGNETFVIHPFYGGDLSKH----PHVIFEARTKANKGCANSG 228

Human   167 QFPAMR------------CGLTEK----EVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVV 215
            ...:.|            .|:.|:    .|.|.:.:..||..                ::|..::
  Fly   229 NLDSWRLSRRTKHLSAGVAGVVEEILQAGVGRNKRDVREATK----------------YIETAII 277

Human   216 VNHDFF-IYSQSNISKVQEDVFLVVNIVDSMYKQLGTYIILIGIEIW--NQGNVFPMTSIEQVLN 277
            |:...| ..:.|..::|..|...|.||.|..::.|.|.:.::.||.|  ||..:.....|.:.::
  Fly   278 VDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAIS 342

Human   278 DFSQWKQISLSQLQHDAAHMFIKNSLI-SILGLAYVAGICRP---PIDCGVDNFQGDTWSLFANT 338
            :|:.:...:|.|::.|...:....:.. ...|:|....:|.|   .|...|:.::.   .|.|.|
  Fly   343 NFNDYTSRNLFQIERDTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVYEP---HLLAGT 404

Human   339 VAHELGHTLGMQHDE--EFCFCGE-RGCIMNTFRVPAE-----KFTNCS---YADFMKTTLNQGS 392
            :||.:||.:||.||:  |.|||.: .||||....|..|     ||:.||   |.|.::|  ..|.
  Fly   405 MAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRT--GHGL 467

Human   393 CLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACC-LLNCTLRPGAACAFGLCCKDCK 456
            ||.|.|  .||.:.:.|||.|||.:|:||||:.::|..|.|| .:.|.|:..|.||.|.||..|:
  Fly   468 CLLNKP--NEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCR 530

Human   457 FMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPC-----SDSAYCYQKRCNNHDQHCRE 516
            ..|...:||...|||||||:|:|...|||.|.:.::|.||     ..|.||:|..|......|..
  Fly   531 LRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEA 595

Human   517 IFGKDAKSASQNCYKEINSQGNRFGHCGINGTT-YLKCHISDVFCGRVQCENVRDIPLLQDHFTL 580
            |:|....:|.:.||::.||:|:..||||.:... |:||...:|.||.:||::....|:......|
  Fly   596 IWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQL 660

Human   581 QHTHINGVTCWGIDYHLRMNISDIGE--------VKDGTVCGPGKICIHKKCVSLSVLSHV---- 633
            ....|  ::..|.::..:.....:|.        |||||.||...||:::.||||  ..||
  Fly   661 YSRTI--ISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSL--FPHVDQTK 721

Human   634 CLPET----CNMKGICNNKHHCHCGYGWSPPYC 662
            |...:    |:..|:|.|.:.|.|..||....|
  Fly   722 CPANSQGLECSEHGVCTNTNRCFCDMGWGGNDC 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAM21	NP_003804.2	Pep_M12B_propep	41..159	CDD:460254	28/114 (25%)
		Cysteine switch. /evidence=ECO:0000250	171..178		2/18 (11%)
		ZnMc_adamalysin_II_like	208..396	CDD:239797	59/205 (29%)
		Disintegrin	415..487	CDD:459709	34/72 (47%)
		ACR	491..627	CDD:214743	45/149 (30%)
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	28/114 (25%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	59/221 (27%)
		Disintegrin	488..561	CDD:459709	34/72 (47%)
		ACR	566..713	CDD:214743	45/148 (30%)