Protein Alignment RIPK1 and SLA1

DIOPT Version :10

• Sequence 1: XP_047275401.1
• Gene: RIPK1 / 8737
• HGNCID: 10019
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_009546.1
• Gene: SLA1 / 852276
• SGDID: S000000103
• Length: 1244
• Species: Saccharomyces cerevisiae
• Alignment Length: 453
• Identity: 93/453 - (20%)
• Similarity: 144/453 - (31%)
• Gaps: 149/453 - (32%)

Human   255 FAVVLWAIFA--NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARP 317
            |..:..|::|  .:.|.|.||.|..|:..::   :.|:||......|.|.|       .:.|...
Yeast     4 FLGIYRAVYAYEPQTPEELAIQEDDLLYLLQ---KSDIDDWWTVKKRVIGS-------DSEEPVG 58

Human   318 TFPG--IEE-----KFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSN 375
            ..|.  |||     |.|..|..:..::.:|::.      .:||.|.........|.:.|.|:.||
Yeast    59 LVPSTYIEEAPVLKKVRAIYDYEQVQNADEELT------FHENDVFDVFDDKDADWLLVKSTVSN 117

Human   376 SATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQP 440
                                 |..|.|                    .||            .:|
Yeast   118 ---------------------EFGFIP--------------------GNY------------VEP 129

Human   441 RQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQ 505
             :|.:.:::|:.       |.|.:.|            |.:.||:..:|...|:.....||   .
Yeast   130 -ENGSTSKQEQA-------PAAAEAP------------AATPAAAPASAAVLPTNFLPPPQ---H 171

Human   506 NNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPT-------MPFSSL 563
            |:..........:..|....||       |..||:.   |...|.....|..       :.:|..
Yeast   172 NDRARMMQSKEDQAPDEDEEGP-------PPAMPAR---PTATTETTDATAAAVRSRTRLSYSDN 226

Human   564 PPTDESIKYTIYNSTGIQIG---------AYNYMEIGGTSSS----LLDSTNTNFKEEPAAKYQA 615
            ...||...| .|||....:|         ::|..||.|....    .:.:...||..:....::.
Yeast   227 DNDDEEDDY-YYNSNSNNVGNHEYNTEYHSWNVTEIEGRKKKKAKLSIGNNKINFIPQKGTPHEW 290

Human   616 IFDNTTSLTD--KHL-----DPIRENLGKHWKNCARKLGFTQSQIDEIDHDYE---RD-GLKE 667
            ..|...|..:  ||:     ||.| :|..|..|..     |..:|..|..:|:   || ||:|
Yeast   291 SIDKLVSYDNEKKHMFLEFVDPYR-SLELHTGNTT-----TCEEIMNIIGEYKGASRDPGLRE 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK1	XP_047275401.1	STKc_RIP1	64..331	CDD:270929	22/84 (26%)
		Death_RIP1	624..709	CDD:260048	17/55 (31%)
SLA1	NP_009546.1	SH3_Sla1p_1	7..64	CDD:212707	16/66 (24%)
		SH3	73..127	CDD:473055	17/112 (15%)
		SH3_Sla1p_3	356..412	CDD:212709
		SHD1	489..554	CDD:427630
		SAM_SLA1_fungal	655..716	CDD:188931
		DUF5585	<723..1040	CDD:465521
		Med15	967..>1230	CDD:312941