Protein Alignment RIPK1 and ripk1l

DIOPT Version :10

• Sequence 1: XP_047275401.1
• Gene: RIPK1 / 8737
• HGNCID: 10019
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_001036815.1
• Gene: ripk1l / 567460
• ZFINID: ZDB-GENE-070705-132
• Length: 661
• Species: Danio rerio
• Alignment Length: 703
• Identity: 271/703 - (38%)
• Similarity: 390/703 - (55%)
• Gaps: 85/703 - (12%)

Human    38 LSFRMQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKG-PNCIEHNEAL 101
            :|..:.|.:      |||:|.::...||.||||:|.||:|:|.|.:::||||.| |......::|
Zfish     1 MSTSVSPSL------MKSADLIKKEPLDYGGFGEVYLCYHKTLGHVVLKTVYTGPPRSGRQKQSL 59

Human   102 LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 166
            |||..:|:||.|.|||||||||:|:|.||||||.:.||||:.:|: :::.|:||||||||||:||
Zfish    60 LEEGSLMSRLNHQRVVKLLGVILEDGDYSLVMELIPKGNLLTMLE-KVTVPISVKGRIILEILEG 123

Human   167 MCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEE-HNELREVDGTAKKNGGT 230
            |.||....||||||||||||||.:|||||||||||:.::||||..|| ..:.|....|:....||
Zfish   124 MVYLTKNQVIHKDLKPENILVDKNFHIKIADLGLATSEVWSKLTKEESRRQSRLGKKTSAHAAGT 188

Human   231 LYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITE 295
            |.|||||||..::.:.:|||||||||:|||.|...:||||:|..|.|:..|:..|.|||...|..
Zfish   189 LCYMAPEHLKSIHTRSSEKSDVYSFAIVLWVILTGREPYEDARSEDQICHCVCQGERPDEALIPP 253

Human   296 YCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQ 360
            ..|.:|..|||.||..:|..||:|.....:|.|||..:|..:|:.|:::|.|.|.....:|::::
Zfish   254 NTPTDITDLMKSCWHQDPLQRPSFTDCYNRFLPFYKEKLAANVKADLENLMKLYEGPEELVEKLK 318

Human   361 SLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPS--------LEHPQEENEPSLQS 417
            .|..:.: :|...|..:.:.|..|.||.   :||||.|....|        ||.....:.|:|:.
Zfish   319 LLNTNAL-IPEDPSLCSRDSPTPLRSSD---IGPVEASIEDLSFRSCEDSVLEADATPSCPNLEL 379

Human   418 KLQDEANYHLYGSRMDRQT-------KQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEG 475
            ||:.|.|||.:|||:..|:       .|||..              |.|..:|....:::.....
Zfish   380 KLEQEYNYHKFGSRIVDQSDGSMWSPAQQPAS--------------STDASSQMSSVKSWTKPSA 430

Human   476 KGT---AYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSH 537
            ..|   .|..||:..:::|:|. |.||..|...::.....|                      :|
Zfish   431 PSTEEELYPRAAASFDSLHRPE-LRSQFSVPQSDHERLRPH----------------------AH 472

Human   538 MPSLHNIPVPE-------------TNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYME 589
            :|.......||             :|...|:|.    :.|.:|.:...:|.|::.||||:||.|.
Zfish   473 LPWNRVKSCPEGANHVAESLIDTNSNLRFNSPV----TYPASDSAFPVSISNASAIQIGSYNTMN 533

Human   590 IGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQID 654
            :..:.||...|.:|........|...:...:.::|:.||:.:|:|:|.:||..|||||.::..::
Zfish   534 LRISDSSPYSSLSTTGSTTSRYKELLLMYESHTVTESHLELVRQNVGANWKQVARKLGLSEIDVE 598

Human   655 EIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLI 707
            .|:|||:||||.|||:|||::|.||||:.|.|||||.|||..|.:.:.|..::
Zfish   599 TIEHDYDRDGLTEKVHQMLERWKMREGLMGITVGKLCQALEGCIKPNALLHML 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK1	XP_047275401.1	STKc_RIP1	64..331	CDD:270929	147/268 (55%)
		Death_RIP1	624..709	CDD:260048	43/84 (51%)
ripk1l	NP_001036815.1	STKc_RIP1	21..289	CDD:270929	147/268 (55%)
		Death_RIP1	568..653	CDD:260048	43/84 (51%)