Protein Alignment RIPK1 and Ripk1

DIOPT Version :10

• Sequence 1: XP_047275401.1
• Gene: RIPK1 / 8737
• HGNCID: 10019
• Length: 712
• Species: Homo sapiens
• Sequence 2: NP_033094.3
• Gene: Ripk1 / 19766
• MGIID: 108212
• Length: 656
• Species: Mus musculus
• Alignment Length: 672
• Identity: 469/672 - (69%)
• Similarity: 540/672 - (80%)
• Gaps: 17/672 - (2%)

Human    42 MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAK 106
            |||||||:.|||.|||.||..:||||||||||||:||:.|.:|:|.||.|||..|:||.||||.|
Mouse     1 MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGK 65

Human   107 MMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLH 171
            ||:||||||||||||:|||||.||||||||||||||||||.::..|||:|||||:|.||||||||
Mouse    66 MMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLH 130

Human   172 GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKK-NGGTLYYMA 235
            .||||||||||||||||.||||||||||:||||.||||..|:.|:.:||..|.|| |||||||||
Mouse   131 DKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMA 195

Human   236 PEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPRE 300
            ||||||:|||||||||||||.:|||||||.||||||.||.:|.::||||||||:|::|.||||||
Mouse   196 PEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPRE 260

Human   301 IISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLD 365
            |||||:.||:|.||.||||.||||:|||||||..||.|||||.||||||.:::.|::||.|||.|
Mouse   261 IISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHD 325

Human   366 CVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGS 430
            ||.:|.|||||  ||||||||||||.|||||||||:.|.|:||:||:.|:|:|||:||:||.:|.
Mouse   326 CVPLPPSRSNS--EQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGI 388

Human   431 RMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSG 495
            ..::|||.|||||.||||||||:||||||||||||..||.::...:|.:..|..|.|.||.|.|.
Mouse   389 FAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSW 453

Human   496 LTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPF 560
            ..:|   ...|||||:.|||       ||.|..|||.|..|.|.|.:..||||||..|:|||||:
Mouse   454 PATQ---TVWNNGLYNQHGF-------GTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPY 508

Human   561 SSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTD 625
            .|.|..|:.|||||:||:|||||.:|||::|..|    ...|...|||..:::||||||||||||
Mouse   509 FSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNS----QPPNNTCKEESTSRHQAIFDNTTSLTD 569

Human   626 KHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKL 690
            :||:|||||||:.|||||||||||:||||||||||||||||||||||||||:||||.||||||||
Mouse   570 EHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKL 634

Human   691 AQALHQCSRIDLLSSLIYVSQN 712
            |||||||.|||||:.||..||:
Mouse   635 AQALHQCCRIDLLNHLIRASQS 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RIPK1	XP_047275401.1	STKc_RIP1	64..331	CDD:270929	207/267 (78%)
		Death_RIP1	624..709	CDD:260048	74/84 (88%)
Ripk1	NP_033094.3	Protein Kinases, catalytic domain	23..291	CDD:473864	207/267 (78%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546	291..567		168/291 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..373		34/47 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..423		26/34 (76%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682	520..536		11/15 (73%)
		Death_RIP1	568..653	CDD:260048	74/84 (88%)