Protein Alignment MYOM1 and robo2

DIOPT Version :9

• Sequence 1: XP_024307049.1
• Gene: MYOM1 / 8736
• HGNCID: 7613
• Length: 1718
• Species: Homo sapiens
• Sequence 2: NP_001259868.1
• Gene: robo2 / 44522
• FlyBaseID: FBgn0002543
• Length: 1519
• Species: Drosophila melanogaster
• Alignment Length: 1014
• Identity: 199/1014 - (19%)
• Similarity: 333/1014 - (32%)
• Gaps: 341/1014 - (33%)

Human   185 TDTEEERI------------------KEAAAYIAQRNLLASEEGITTSKQSTAS----------- 220
            |||...||                  .:|..|..:..   :|.|:..|:.:|..
  Fly   133 TDTGSHRIMLPAGGLFFLKVIHSRRESDAGTYWCEAK---NEFGVARSRNATLQVAFLRDEFRLE 194

Human   221 -KQTTASKQSTASKQSTASKQS----TASRQSTASRQSVVSKQ------ATSALQQEETSEKKSR 274
             ..|..::...|..:..|.:.|    .:.|::..:...|.:|:      ...|:|:...|:....
  Fly   195 PANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRY 259

Human   275 KVVIREKAERLSLRKTLEETETYHAKLNEDHLLHAPEFIIK-PRSHTVWEKENVKLHCSIAGWPE 338
            :.|::...       ...|:.|...|      :|...|:|: |::.|.....:|...|.|.|.|.
  Fly   260 QCVVKNVV-------GTRESATAFLK------VHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPL 311

Human   339 PRVTWYK----NQVPI-NVHANPGKYIIESRYGMHTLEINGCDFEDTAQYRASAMNVKGELSAYA 398
            |.|.|.:    ..:|: .||      ::|.|    :|:::....||..:|...|.|..|.::|..
  Fly   312 PDVLWRRTASGGNMPLRRVH------VLEDR----SLKLDDVTLEDMGEYTCEADNAVGGITATG 366

Human   399 SVVVK-------RYKGEF----DETRFHAGASTMP-----------------------LSFGVTP 429
            .:.|.       |.|.:.    ||..|...|:..|                       :...:||
  Fly   367 ILTVHAPPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTP 431

Human   430 YG----------------------------YASRFEIHFDDKFD-----VSFGREGETMS----- 456
            .|                            .:||..:..|.:|:     :..|...:|:.
  Fly   432 EGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIV 496

Human   457 -LGCRVVITPEIKHFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNK-EDEGLYTIRVRM 519
             |.||.:.||     .|::.||.:|:|:...:..:...| :...||.|.|.: |||||||.....
  Fly   497 VLPCRTLGTP-----VPQVSWYLDGIPIDVQEHERRNLS-DAGALTISDLQRHEDEGLYTCVASN 555

Human   520 GEYYEQYSAYV-----------FVRDADAEIEGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSP 573
            ......:|.|:           |.|  ..|:...|..|...:.:|..::.:.:||.:....|||.
  Fly   556 RNGKSSWSGYLRLDTPTNPNIKFFR--APELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSS 618

Human   574 ILGYFID---KCEVGTDSWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPV 635
            ::||.|:   |.|  ||.|.... |.|:...|..|||:.|.:|.|.:||.|..|:..||.:|||:
  Fly   619 LVGYVIEMFGKNE--TDGWVAVG-TRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPSPMSEPI 680

Human   636 AALDPAEKARLKSRPSAPWTGQIIVTEEEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHE 700
            ..
  Fly   681 TV--------------------------------------------------------------- 682

Human   701 GIMYFVEKCEAGTENWQRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVV 765
            |..||              |:.|          ||                     |||....:.
  Fly   683 GTRYF--------------NSGL----------DL---------------------SEARASLLS 702

Human   766 GDKLDIPKAPGKIIPSRNTDTSVVVSWEESKDAKELVGYYIEA-----SVAGSGKWEPCNNNPVK 825
            ||.:::..|  .::.|    ||:.::| :..:.|.:.|:|:.|     .:..:......|.||:.
  Fly   703 GDVVELSNA--SVVDS----TSMKLTW-QIINGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLL 760

Human   826 GSRFTCHGLVTGQSYIFRVRA-VNAAGLSEYSQDSEAIEVKAAIGGGVSPDVCPALSDEPGGLTA 889
            ||..|........|.:...:. :.|||    .:|.|..:    .|||.
  Fly   761 GSTSTSASASASASALISTKPNIAAAG----KRDGETNQ----SGGGA----------------- 800

Human   890 SRGRVHEASPPTFQKDALLGSKPNKPSLPSSSQNLGQTEVSKVSETVQEELTPPPQKAAPQGKSK 954
                      ||     .|.:|....::.:.......|....|..|:.|....|..|:. :||..
  Fly   801 ----------PT-----PLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSV-EGKPS 849

Human   955 SDPLKKKTDRAPPSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYVNYREVIDGVPGKWREA 1019
            :..:.:..:..|...|..:..|.....::.|.||.|:.   .:..|..:||..::.|:......:
  Fly   850 NSRIARTLEDVPSEAPYGMEALLLNSSAVFLKWKAPEL---KDRHGVLLNYHVIVRGIDTAHNFS 911

Human  1020 NVKA-----VSEEAYKISNLKENMVYQFQVAAMNMAGLG 1053
            .:..     .:.....::||.|.::|...|||.|.||:|
  Fly   912 RILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVG 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYOM1	XP_024307049.1	IG	316..402	CDD:214652	23/90 (26%)
		I-set	450..517	CDD:333254	23/73 (32%)
		FN3	543..633	CDD:238020	31/92 (34%)
		FN3	671..764	CDD:238020	10/92 (11%)
		FN3	772..862	CDD:238020	21/95 (22%)
		FN3	967..1061	CDD:238020	21/92 (23%)
		FN3	1072..1161	CDD:238020
		I-set	1188..1254	CDD:333254
		I-set	1407..1476	CDD:333254
		Ig_Myomesin_like_C	1605..1696	CDD:319300
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	11/54 (20%)
		I-set	91..184	CDD:254352	11/53 (21%)
		I-set	190..279	CDD:254352	14/101 (14%)
		Ig2_Robo	193..279	CDD:143201	14/98 (14%)
		I-set	283..370	CDD:254352	25/96 (26%)
		Ig	300..370	CDD:299845	21/79 (27%)
		Ig	388..>457	CDD:299845	8/68 (12%)
		I-set	479..561	CDD:254352	24/87 (28%)
		Ig	496..561	CDD:143165	22/70 (31%)
		FN3	588..681	CDD:238020	34/95 (36%)
		FN3	<817..856	CDD:238020	8/39 (21%)
		fn3	864..952	CDD:278470	21/90 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8219
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950