Protein Alignment MYH13 and Prm

DIOPT Version :10

• Sequence 1: NP_003793.2
• Gene: MYH13 / 8735
• HGNCID: 7571
• Length: 1938
• Species: Homo sapiens
• Sequence 2: NP_523982.2
• Gene: Prm / 39002
• FlyBaseID: FBgn0003149
• Length: 879
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 285/831 - (34%)
• Similarity: 487/831 - (58%)
• Gaps: 1/831 - (0%)

Human  1100 DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164
            |..:..:|....:..|:.:|..|::::|.|..||.:||::::||:.::.::|||||||.|....|
  Fly    25 DVNIEYIQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQ 89

Human  1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229
            .|.|:||:||..|:|:.||:..|:.|.|...|:||..:.:.:..||::.|.:.|.:.||:|::.:
  Fly    90 FEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQ 154

Human  1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHR 1294
            .|:.::.|.||:.:|.|...|:....:|...||:..|.|:..:.:.|::..::||..:|.||:..
  Fly   155 TEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKD 219

Human  1295 VEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKA 1359
            |::.:..:..::.||..:..|||:.:|::|:|.:.::.:..:|.....:.|.:|.|.|||.||:.
  Fly   220 VQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARI 284

Human  1360 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQR 1424
            :|:|.|.|||::...|:.|:.::...|.||:||.::|...|:.|.||:.|:...|..:|||.|.|
  Fly   285 DLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTR 349

Human  1425 LQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR 1489
            |..|||.|:.|||:|:.:|..|.|.....:|...|.|.:|||:....|.:|::.::...:|.:..
  Fly   350 LASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTV 414

Human  1490 NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS 1554
            :..::|.|....|.||||.|.:::.:....|.|..:.|.|.|...:.:|.|:.:|..|.:|.|..
  Fly   415 HELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAG 479

Human  1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS-VLDAEIRSRNDALRL 1618
            .:.||.:..|:..:.:|.:.:.:|::.|||||||.:::.:....|.|.: |::||.|.:.:..|:
  Fly   480 RKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRI 544

Human  1619 KKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNG 1683
            |||::..:.|:|:.|..:|:...:.||.::....||.:.|.|.:|..|..:...:|.|:.:||..
  Fly   545 KKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLA 609

Human  1684 LLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS 1748
            .|..||||::..|:...|.:|..|.:..:|:.|:..|.:.|.||::.|.|||.:::...::.|..
  Fly   610 GLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEV 674

Human  1749 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
            .:|.|.::|:.:|...:...:.|::.:||:....||.:||:||..||:|..||:|.|..|:.|.|
  Fly   675 SKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSK 739

Human  1814 KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAK 1878
            :.|.|||.|:|:||.||:.|::|.||.:|...|.||.|||:..|.|||.||::.|||.:||..||
  Fly   740 RIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAK 804

Human  1879 VKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSR 1929
            :..|:||..|.|..:....:|.||.|.|||.|.:|||.|||.:|.:|||.|
  Fly   805 INIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	33..77	CDD:460670
		MYSc_Myh13	100..770	CDD:276887
		Actin-binding. /evidence=ECO:0000250	659..681
		Actin-binding. /evidence=ECO:0000250	761..775
		Myosin_tail_1	850..1927	CDD:460256	282/827 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1917..1938		8/13 (62%)
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:460256	280/818 (34%)