DRSC/TRiP Functional Genomics Resources

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Protein Alignment MYH13 and didum

DIOPT Version :9

Sequence 1:NP_003793.2 Gene:MYH13 / 8735 HGNCID:7571 Length:1938 Species:Homo sapiens
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1888 Identity:482/1888 - (25%)
Similarity:844/1888 - (44%) Gaps:444/1888 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    81 NPPKFDKIEDMAMMTHLHEPAVLYNLKERYA-AWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYR 144
            ||.......|:..:::||||.||:||:.|:. ..:||||.|:..|.:|||..:|:|.|.::.|||
  Fly    65 NPAILVGQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYR 129

Human   145 GKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKET 209
            |....:..||||::::.||..:..:..|.||:::|||||||||:.|..::|||.:   |..:.||
  Fly   130 GHAMGDLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV---GGSESET 191

Human   210 QPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GATGK--LASADIETYLLE 271
            |       :|.:::.::|::||||||||.|||||||||||.::.| ...|.  |..|.:.|||||
  Fly   192 Q-------VERKVLASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLE 249

Human   272 KSRVTFQLSSERSYHIFYQIMS--NKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLAT 334
            ||||.:|...||:||||||:.:  :|.|||:   |...:.|.|..:. |...:..:.|:|:...|
  Fly   250 KSRVVYQAQGERNYHIFYQLCAARSKYPELV---LDHQDKFQFLNMG-GAPEIERVSDAEQFNET 310

Human   335 DNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEV----------ADKAG 387
            ..|:.:||||.::...|.|:...::|.||::..:|..|  |:.:.|..::          ||   
  Fly   311 VQAMTVLGFSIQQIADIVKILAGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITAD--- 372

Human   388 YLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTK 452
             |:.:::.::.:.|...:::..||||....:::....:..||||.:|.|:|.::|..:|:.|:..
  Fly   373 -LLRVSADDLRRWLLMRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNG 436

Human   453 QPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGM 517
            ..:..|||||||.|||.|:.||.||.|||:.||||||.||.|:|.||||||.||||.|..||| .
  Fly   437 SKQCSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-Y 500

Human   518 DLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSN---NFQKPKPAKGKAEAHF 579
            |...||:|||..:|:..:|:|||..||.:|.|:..||    :||.|   :|:||:    .....|
  Fly   501 DNQPCIDLIESRLGVLDLLDEECRMPKGSDESWAGKL----IGKCNKFPHFEKPR----FGTTSF 557

Human   580 SLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFS-------NYAGAETGDSGGS 637
            .:.|::.||:|::.|:|:||:|.:::.:..:..:|::.|...:.:       ....|::...||.
  Fly   558 FIKHFSDTVEYDVNGFLEKNRDTVSKELTQVLSESNMSLAKQVMTLEEIDTLCVDSAKSSTLGGR 622

Human   638 ---KKGGKKKGSSF-----------QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVM 688
               ..|.|::|:..           :||.:.|:|:|..|::.|.:|.||:|||:.||:.|.....
  Fly   623 VVISAGRKQQGNDTRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKW 687

Human   689 DHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRIL-NASAIPEGQFIDSKNASEKLLNS 752
            :...::.|||..||||.:||...|||||.||.||..||::| ..|.:.:.   |.|.:...::..
  Fly   688 ETAKIIQQLRACGVLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMK 749

Human   753 IDVDREQFRFGNTKVFFKAGLLGLLEEMR---DEKLVTLMTST--------------------QA 794
            ...|.:::|||||::||:||.:..||::|   .:|.:|::.|.                    |.
  Fly   750 WIQDEDKYRFGNTQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQK 814

Human   795 VCRGYLMRVEFKKMMERRDSIFCIQYN-----IRSFMNVKH-----------WPWMNLF------ 837
            ..||||.|...:||.|.|..:...:|.     .|.::.::|           ....|.|      
  Fly   815 HARGYLARERTQKMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDH 879

Human   838 ---FKIKPLLKSAEAEKEMATMKED----------------FERTKEE---LARSEARRKELEEK 880
               .:|:..::.|.|.:.....:.:                |:|.|.|   ::..|.:...||.|
  Fly   880 YRAVQIQRFVRGALARRAYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENKYMGLENK 944

Human   881 MVSLLQEKNDLQ---------------LQVQSETENLMDAEER-----CEGLIKSKIL------L 919
            ::|:.|..::|.               |:::.|.:..::||.:     |:.  |.|::      |
  Fly   945 IISMQQRIDELNRDNSNLKHKTSEISVLKMKLELKKTLEAEFKNVKAACQD--KDKLIEALNKQL 1007

Human   920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984
            ||:..|..:.|||......|.:::|:....:...|:|.||::      ::..|:|..|: :|..:
  Fly  1008 EAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEI------IDMAKNAEVNQ-RNQED 1065

Human   985 EMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDK-----------VNGLIKINAK-----LEQ 1033
            .|.|..:|        :.|.||:|:.:.|.:|.|::           ..|...::|:     ..|
  Fly  1066 RMLAEIDN--------RELNEAYQRAIKDKEVIENENFMLKEELSRLTAGSFSLHARKASNASSQ 1122

Human  1034 QTDDL-----EGSLEQEK-------------------KLRADLERAKRKLEGDLKMSQESIMDLE 1074
            ..||:     :.:|:..:                   |||:.||..|:|    .|:.||..:.|.
  Fly  1123 NEDDVGYASAKNTLDINRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQK----HKVLQEQYIKLS 1183

Human  1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVH-SLQFQKKIKELQARIEELEEEI--EAEHTLRAK- 1135
            :..:..|:..:..|.|:...:.:.:.:|:. |::...:|.||.|:...|:||:  ..|..::.| 
  Fly  1184 SRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHGVEINELNAQHAALQEEVRRRREECIQLKA 1248

Human  1136 IEKQRSDLARELE---------EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
            :..|:|...|.||         :::|.:|    |..:|..:|::.|:|       |:..|.:|.:
  Fly  1249 VLLQQSQSMRSLEPESLQMRGNDVNELME----AFHSQKLINRQLESE-------LKAITEEHNS 1302

Human  1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTV 1256
                       .:.|:.::|:.|...|.:|:|...|...|.:|  ||::.|.::...:.|..:..
  Fly  1303 -----------KLVEMTQEIERLNNEKDELQKVMFESIDEFED--SNVDTLRQNDRYLRRELQKA 1354

Human  1257 EDQFSEIKAKDEQQTQLIHDLNMQKARLQT---QNGELSHRVEEKESLISQLTKSKQALTQQLEE 1318
            ..||..::          .:|.:..|:|:.   ..|:|.|::|                    ||
  Fly  1355 VAQFLLVQ----------EELKLANAKLKAYRQDGGQLEHKIE--------------------EE 1389

Human  1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT------ 1377
            :.|.....|.|........|.|::...|::....:..:.   |||.||....     ||      
  Fly  1390 MIRNKSNGTSADVGANVTKQKSQNPQGLMKFHSSDLDKI---LQRLLSALTP-----RTVVGLLP 1446

Human  1378 -----------KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED 1431
                       :| ||.....:::.|...|...::::              :.:|...::..|..
  Fly  1447 GFPAYLIFMCIRY-TDLTNADDDVRELLSKFVIQIKK--------------MHRTPHPIENRVIW 1496

Human  1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMR------- 1489
            |:..:     ....|.|:..:.|:.:....:|.::.|.:           :..||:.|       
  Fly  1497 LVNSI-----TLLNLMKQYGDVDEYVKFNTEKQNQQQLK-----------NFNLFEYRRVILDLI 1545

Human  1490 -NAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQV------- 1546
             |.|:.::.|::.|             |..:|.....|..|.::.::..........:       
  Fly  1546 VNLYQALIMQIQGL-------------LDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPE 1597

Human  1547 -----ALEEVEGSLEH-------------------------------------------EESKIL 1563
                 |.:::.|.|||                                           |...|:
  Fly  1598 HGGGPAWKQLIGQLEHFYKQFQHFGLDNCYAEQIFHQLLYFICAVALNCLMLRGDICMWETGMII 1662

Human  1564 RVQLELSQ--VKS-ELDRKVIEKDEEIEQLKR--NSQRAAEALQSVLD-AEIRSRNDALRLKKKM 1622
            |..:...:  |:| ::...|:.....:.|:.:  .|:::.:.:|::.| ....|....|::.|..
  Fly  1663 RYNIGCIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDVQTICDLCTSLSTAQVLKVMKSY 1727

Human  1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE 1687
            :.|..|.||    :|..:.:..:.|...|.|..:|     |....::...:...:|.|.:.:.||
  Fly  1728 KLDDYESEI----TNVFLEKLTEKLNARQMQKSNS-----DEFTIDQKFIQPFKVVFRYSDIKLE 1783

Human  1688 ELE 1690
            ::|
  Fly  1784 DIE 1786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MYH13NP_003793.2 Myosin_N 36..73 CDD:280832
Myosin_head 88..770 CDD:278492 268/724 (37%)
MYSc_Myh13 100..770 CDD:276887 264/712 (37%)
Actin-binding. /evidence=ECO:0000250 659..681 10/21 (48%)
Actin-binding. /evidence=ECO:0000250 761..775 9/13 (69%)
Myosin_tail_1 850..1927 CDD:279860 185/1028 (18%)
RILP-like <1273..1399 CDD:304877 27/145 (19%)
TMPIT 1744..>1837 CDD:285135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1917..1938
didumNP_724569.1 MYSc 65..778 CDD:214580 275/742 (37%)
MYSc_Myo5 84..767 CDD:276831 264/712 (37%)
IQ 900..922 CDD:197470 0/21 (0%)
GBP_C <971..1086 CDD:303769 31/131 (24%)
coiled coil 1049..1068 CDD:293879 4/25 (16%)
coiled coil 1077..1086 CDD:293879 3/8 (38%)
JAKMIP_CC3 <1190..1299 CDD:292653 28/119 (24%)
Myo5_CBD 1424..1792 CDD:271254 64/424 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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