Protein Alignment MYH13 and ck

DIOPT Version :10

• Sequence 1: NP_003793.2
• Gene: MYH13 / 8735
• HGNCID: 7571
• Length: 1938
• Species: Homo sapiens
• Sequence 2: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Alignment Length: 2080
• Identity: 534/2080 - (25%)
• Similarity: 871/2080 - (41%)
• Gaps: 464/2080 - (22%)

Human    52 IQTRENDKVIVKTLDDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIY 116
            ||.|::|       .|.:......::..|:......:|||..:..|||..:|.||..||...:||
  Fly    36 IQVRDDD-------GDEVWLAPERRIKAMHASSVQGVEDMISLGDLHEAGILRNLLIRYKENLIY 93

Human   117 TYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGES 181
            ||:|...|.||||:.||:|..:.:..|:.:|..|.|||||:|.||||..|...|.:|.|:|:|||
  Fly    94 TYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNAYAHMKRYRQDQCIVISGES 158

Human   182 GAGKTVNTKRVIQYFATIAVTGDKKKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRF 246
            |||||.:||.::||.|.|:           || ...:|.||::|||:|||||||||:||||||||
  Fly   159 GAGKTESTKLILQYLAAIS-----------GK-HSWIEQQILEANPILEAFGNAKTIRNDNSSRF 211

Human   247 GKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQI---MSNKKPELIDLLLISTN 308
            ||:|.|||.|.|.:..|.||.|||||||:..|..|||:||:||.|   :|..:...:||.:.:
  Fly   212 GKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNYHVFYCILAGLSADEKSRLDLGMAA-- 274

Human   309 PFDFPFVSQG-EVTVASIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQRE 372
              |:.:::.| .:|....||:.|.....:|:.:|.||.:|...|.||..|::|.||:|:|....:
  Fly   275 --DYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIWEIIKLLAALLHCGNIKYKATVVD 337

Human   373 EQAEPDGTEV-----ADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKA 432
            ..   |.||:     .::...|:||....::..|....:....|.|....:..|..:...|..|.
  Fly   338 NL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAHGETVVSTLSRDQSVDVRDAFVKG 399

Human   433 VYEKMFLWMVTRINQQLDTKQPR---QYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHH 494
            :|.:||:.:|.:||..:  .:||   :..||||||.|||.||.||.||.|||:.||.|||||..|
  Fly   400 IYGRMFVHIVRKINTAI--FKPRGTSRNAIGVLDIFGFENFDQNSFEQFCINYANENLQQFFVQH 462

Human   495 MFVLEQEEYKKEGIEWEFIDFGMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQH 558
            :|.||||||..|.|.|:.|:| :|....::||. |.:.|.::::||..|||.||.:...||:..|
  Fly   463 IFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNIMALIDEEARFPKGTDQTMLAKLHKTH 526

Human   559 LGKSNNFQKPKPAKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLF 623
             |...|:.||   |......|.|.|:||.|.|:..|:||||:|..:..::.|..:|:.|.|..:|
  Fly   527 -GSHKNYLKP---KSDINTSFGLNHFAGVVFYDTRGFLDKNRDTFSPDLLHLVSQSTNKFLRQIF 587

Human   624 SN--YAGAETGDSGGSKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPG 686
            :.  ..||||          :|:   ..|:|..||::|:.||..|.|..|.|:||:.|||.|.|.
  Fly   588 AQDIEMGAET----------RKR---TPTLSTQFRKSLDALMKTLSSCQPFFIRCIKPNELKKPM 639

Human   687 VMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQFIDSKNASEKLLN 751
            :.|..|...|||.:|::|.|||.|.|:|.|..:.:|.:|||.| ...:|.....|.:.|:.::.
  Fly   640 MFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFREFVERYRFL-IPGVPPAHRTDCQAATSRIC- 702

Human   752 SIDVDREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIF 816
            ::.:.:..::.|:||||.|......||:.||..|...:...|...||::.|..|.::   |.:..
  Fly   703 AVVLGKSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVYRRRFLRL---RAAAI 764

Human   817 CIQYNIRSFMNVKHWPWMNL-FFKIKPLLKSAEAEKEMATMKEDFERTKEEL------ARSEARR 874
            .:|...:.:...|.:..|.: :.:::.|::|       ..:...|...:..:      ||....|
  Fly   765 TVQRFWKGYAQRKRYRNMRVGYMRLQALIRS-------RVLSHRFRHLRGHIVGLQAHARGYLVR 822

Human   875 KELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLE----AKVKELTERLEEEEE 935
            :|...||.::        :::||....:: |..|..     |:.||    |:|.:| .:|||:|.
  Fly   823 REYGHKMWAV--------IKIQSHVRRMI-AMRRYR-----KLRLEHKQFAEVLQL-RKLEEQEL 872

Human   936 MNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000
            ::                               ...|||.|...::..:.:..||....:...|.
  Fly   873 LH-------------------------------RGNKHAREIAEQHYRDRLHELERREIQEQLEN 906

Human  1001 KSLQEAHQQTLDD-LQVEEDKVNGLIKINAKL-EQQTDDLEGSLE--------QEKKLRADLERA 1055
            :...|.:...::| .:.:|:.|:     :.|| |...|.|..|..        :|..:..||..|
  Fly   907 RRRVEVNMNIINDAARKQEEPVD-----DGKLVEAMFDFLPDSSSDAPTPHGGRETSVFNDLPHA 966

Human  1056 KRKLEGDLKMSQESI---MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK-----I 1112
            :       .::|:.|   :.:..|::.:.| .|.::|..:..|..::.      |:.||     :
  Fly   967 Q-------NVNQDDIIAPIHISEDEEDLSE-FKFQKFAATYFQGNVNH------QYAKKALKHPL 1017

Human  1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS--GATSAQIEMNKKREAEF 1175
            ..|..:.::|     |...|...|.:...|:........:|::..|  ...:|.:..|..|..||
  Fly  1018 LPLHTQGDQL-----AAQALWITILRFTGDMPEPKYHTMDRMDTTSVMSKVTATLGRNFIRSKEF 1077

Human  1176 QK---MRRD------LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
            |:   |..|      .:..:::|:..:.||::|.     :|||.      |:::|:.:    :..
  Fly  1078 QEAQLMGLDPDAFLKQKPRSIRHKLVSLTLKRKN-----KLGED------VRRRLQDD----EYT 1127

Human  1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDL------------------- 1277
            .|...|.::  |:..||:|:....:.......:.:||...|:...|
  Fly  1128 ADSYQSWLQ--SRPTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLC 1190

Human  1278 -----------NMQKA---------------RLQT--QNGELSHRVEEKESLISQLTKSKQAL-- 1312
                       |..:|               ||:.  .||.   |.:....|..|.||||:.:
  Fly  1191 VGCFAPSEKFVNYLRAFIREGPPGYAPYCEERLKRTFNNGT---RNQPPSWLELQATKSKKPIML 1252

Human  1313 --------TQQL--------EELKRQMEEETKAKNAMAHAL------------QSSRHDCDLLR- 1348
                    |:.|        .||..|:.::...|:....:|            ....|..|.:.
  Fly  1253 PITFMDGNTKTLLADSATTARELCNQLSDKISLKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQ 1317

Human  1349 -EQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEAEENTET 1410
             |||.:||.|:           ...|.||..:..:......  |....::|..|  |:.....:.
  Fly  1318 CEQYAKEQGAQ-----------ERNAPWRLFFRKEIFAPWH--EPTHDQVATNLIYQQVVRGVKF 1369

Human  1411 ANSKCASLEKTKQRLQGEVEDLM--------------RDLERSHTACATL--DKKQRNFDKVLAE 1459
            ...:|           .:.|||.              ..:||..|.....  |......||.:..
  Fly  1370 GEYRC-----------DKEEDLAMIAAQQYFIEYSTDMSMERLFTLLPNFIPDFCLSGVDKAIER 1423

Human  1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ------------LETLRRENKNLQEE 1512
            |       .|.:..|.|:|..:..::..:: ..|::|..            .|..|....||.:
  Fly  1424 W-------AALVLQAYKKSYYVKDKIAPLK-IKEDIVSYAKYKWPLLFSRFYEAYRNSGPNLPK- 1479

Human  1513 ISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELD 1577
             :|:...:..||..:.:        :||:..|:::..|:......:.:|:......||.|:.|..
  Fly  1480 -NDVIIAVNWTGVYVVD--------DQEQVLLELSFPEITAVSSQKTNKVFTQTFSLSTVRGEEF 1535

Human  1578 RKVIEKDEEI--------EQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ-- 1632
            .......|:|        :.||:.|:... |||     :.|:.:|........:|||..:|.:
  Fly  1536 TFQSPNAEDIRDLVVYFLDGLKKRSKYVI-ALQ-----DYRAPSDGTSFLSFFKGDLIILEDESC 1594

Human  1633 ----------LGHSNRQM------AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERR 1681
                      :|..:|..      |||...|.|:.              :..:|:.....|.|..
  Fly  1595 GESVLNNGWCIGRCDRSQERGDFPAETVYVLPTLS--------------KPPQDILALFNIEEAH 1645

Human  1682 NGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQL--LHSQNTSLINTKKKLEADIAQCQAE 1744
            :|..| .:.....|:|..:|...|.|..|    |..:|  ..:.:.:|..:.|:.|......:..
  Fly  1646 HGRRL-SMASNGGAVEPRDRPHTLMEYAL----DHFRLPPKRTMSKTLTLSSKRSEELWRYSRDP 1705

Human  1745 VENS-IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD--LQHRL--DEA 1804
            ::.. :::.::.||.|::|   ....|..||...|..:...||...:...:.|  |:|.:  ||.
  Fly  1706 IKAPLLRKLQSKEEFAEEA---CFAFAAILKYMGDLPSKRPRMGNEITDHIFDGPLKHEILRDEI 1767

Human  1805 EQLALKGGKKQIQKLENRVRELENELDVEQKRGAEAL----------KGAHKYERKVKEMTYQAE 1859
            ....:|      |..:||.|       :.::||.|.:          :|.      :||:..
  Fly  1768 YCQLMK------QLTDNRNR-------MSEERGWELMWLATGLFACSQGL------LKELLL--- 1810

Human  1860 EDHKNILRL------QDLVDKLQAKVKSYKR-----QAE-EAEEQANTQLSRCRRVQHELEEAAE 1912
                 .||.      ||.:.:||..::..:|     |.| ||.:...||:........:.:||.|
  Fly  1811 -----FLRTRRHPISQDSMHRLQKTIRHGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFE 1870

Human  1913  1912
              Fly  1871  1870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	33..77	CDD:460670	5/24 (21%)
		MYSc_Myh13	100..770	CDD:276887	271/684 (40%)
		Actin-binding. /evidence=ECO:0000250	659..681		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	761..775		6/13 (46%)
		Myosin_tail_1	850..1927	CDD:460256	234/1266 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1917..1938
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	271/684 (40%)
		MyTH4	<1138..1245	CDD:214535	16/109 (15%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	18/108 (17%)
		B41	1251..1467	CDD:214604	39/247 (16%)
		FERM_C1_MyoVII	1461..1559	CDD:270019	20/107 (19%)
		SH3	1560..1624	CDD:473055	15/69 (22%)
		MyTH4	1701..1849	CDD:214535	37/177 (21%)
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613	4/17 (24%)
		B41	1856..2068	CDD:214604	3/15 (20%)
		FERM_C2_MyoVII	2064..2159	CDD:270020