DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH13 and Myh6

DIOPT Version :9

Sequence 1:	NP_003793.2	Gene:	MYH13 / 8735	HGNCID:	7571	Length:	1938	Species:	Homo sapiens
Sequence 2:	NP_058935.2	Gene:	Myh6 / 29556	RGDID:	62029	Length:	1939	Species:	Rattus norvegicus

Alignment Length:	1937	Identity:	1506/1937 - (77%)
Similarity:	1713/1937 - (88%)	Gaps:	2/1937 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     3 SDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTLDD 67
            :||:||.||.|||||||.||||:|||.||||.:..|||.|:||.|||..|.:||..||..:|.:.
  Rat     2 TDAQMADFGAAAPYLRKSEKERLEAQTRPFDIRTECFVPDDKEEYVKAKIVSREGGKVTAETENG 66

Human    68 RMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWL 132
            :.:|:..|||...|||||||||||||:|.||||||||||||||||||||||||||||||||||||
  Rat    67 KTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWL 131

Human   133 PVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFA 197
            |||..|||||||||||.|||||||||||||||:|||||:||||||||||||||||||||||||||
  Rat   132 PVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFA 196

Human   198 TIAVTGDKKKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 262
            :||..||:.|:..|...:||||||||||||.||||||||||||||||||||||||||||||||||
  Rat   197 SIAAIGDRSKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLAS 261

Human   263 ADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDD 327
            |||||||||||||.|||.:||:|||||||:|||||||:|:||::.||:|:.|||||||:||||||
  Rat   262 ADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDD 326

Human   328 SEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGL 392
            ||||||||:|.|:|||::|||.|:||||||:|||||||||||||||||||||||.|||:.|||||
  Rat   327 SEELLATDSAFDVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGL 391

Human   393 NSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQY 457
            |||::|||||.||||||||||||||:||||..|:|||||:||||||.|||||||..|:|||||||
  Rat   392 NSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQY 456

Human   458 FIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAAC 522
            |||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||.||
  Rat   457 FIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQAC 521

Human   523 IELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHYAGT 587
            |:||||||||.||||||||||||||.:||.||||.|||||||||||:..|||.||||||||||||
  Rat   522 IDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGT 586

Human   588 VDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSFQTVS 652
            |||||.|||:|||||||||||||||||||||::.|||.||.|:|||| |..||||||||||||||
  Rat   587 VDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDS-GKGKGGKKKGSSFQTVS 650

Human   653 AVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRI 717
            |:.||||||||||||:||||||||:||||.|.|||||:.|||||||||||||||||||||||:||
  Rat   651 ALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRI 715

Human   718 LYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEMRD 782
            ||.||:|||||||.:||||||||||:..:||||.|:|:|..|::||:||||||||||||||||||
  Rat   716 LYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRD 780

Human   783 EKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSA 847
            |:|..::|..||..||.|||:|||||:||||::..||:|||:||.||:||||.|:||||||||||
  Rat   781 ERLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSA 845

Human   848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGL 912
            |.|||||.|||:|.|.|:.|.:|||||||||||||||||||||||||||:|.:||.||||||:.|
  Rat   846 ETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQL 910

Human   913 IKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATEN 977
            ||:||.|||||||:|||||:|||||:||.||||.|||:||.||:|||||||||.|||||||||||
  Rat   911 IKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 975

Human   978 KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
            |||||:|||..|:|.|:|||||||:|||||||.|||||.||||||.|||...|||||.|||||||
  Rat   976 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLIKSKVKLEQQVDDLEGSL 1040

Human  1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQ 1107
            |||||:|.||||||||||||||::|||||||||||.|:|||||||||::||..:||:|||..:||
  Rat  1041 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDISQQNSKIEDEQALALQ 1105

Human  1108 FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRE 1172
            .|||:||.||||||||||:|||.|.|||:||.||||.|||||||||||||.||||.|||||||||
  Rat  1106 LQKKLKENQARIEELEEELEAERTARAKVEKLRSDLTRELEEISERLEEAGGATSVQIEMNKKRE 1170

Human  1173 AEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS 1237
            ||||||||||||||||||||||.||||.|||||||||||||||||||||||||||.|:|:||:.|
  Rat  1171 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235

Human  1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302
            |:|.:.|:|:|:|:..||:|||.:|.:.|.|:..:.::|...|:|:|||:||||:.::||||:||
  Rat  1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALI 1300

Human  1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSK 1367
            ||||:.|.:.|||:|:||||:|||.|||||:||||||:||||||||||||||.||||||||.|||
  Rat  1301 SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEEMEAKAELQRVLSK 1365

Human  1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL 1432
            |||||||||||||||||||||||||||||||||||:|||..|..|:||:||||||.|||.|:|||
  Rat  1366 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430

Human  1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
            |.|:|||:.|.|.||||||||||:|||||||.:|||:|||::|||:|||||||||::|||||.::
  Rat  1431 MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1495

Human  1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562
            .|||.:||||||||||||||||:.|.|||:.|.||.:|.:|.||.:||.||||.|.||||||.||
  Rat  1496 HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLELQSALEEAEASLEHEEGKI 1560

Human  1563 LRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLN 1627
            ||.|||.:|:|:|::||:.|||||:||.|||..|..::||:.||||.||||:|||:|||||||||
  Rat  1561 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1625

Human  1628 EMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
            ||||||..:||..:|.||||:..|..|||:||.||||:|:|:||||.:|||||||.||..||||:
  Rat  1626 EMEIQLSQANRIASEAQKHLKNAQAHLKDTQLQLDDAVRANDDLKENIAIVERRNTLLQAELEEL 1690

Human  1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
            :..:|||||:|:|:||||::.|:||||||||||||||.|||::||::|.|.|||.::||.|||||
  Rat  1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1755

Human  1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENR 1822
            ||||||||||||||||||||||||||||||||:|||:||||||||||||:||||||||:||||.|
  Rat  1756 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820

Human  1823 VRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAE 1887
            ||||||||:.||||.||::||..|.||::||:|||.|||.||::||||||||||.|||:||||||
  Rat  1821 VRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLVRLQDLVDKLQLKVKAYKRQAE 1885

Human  1888 EAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGS-QKMEE 1938
            ||||||||.||:.|:|||||:||.|||||||||||||||||||:|: |||.:
  Rat  1886 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHD 1937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	36..73	CDD:280832	16/36 (44%)
		Myosin_head	88..770	CDD:278492	576/681 (85%)
		MYSc_Myh13	100..770	CDD:276887	566/669 (85%)
		Actin-binding. /evidence=ECO:0000250	659..681		19/21 (90%)
		Actin-binding. /evidence=ECO:0000250	761..775		11/13 (85%)
		Myosin_tail_1	850..1927	CDD:279860	813/1076 (76%)
		RILP-like	<1273..1399	CDD:304877	98/125 (78%)
		TMPIT	1744..>1837	CDD:285135	81/92 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1917..1938		18/21 (86%)
Myh6	NP_058935.2	Myosin_N	34..72	CDD:397036	16/37 (43%)
		MYSc_class_II	99..768	CDD:276951	566/669 (85%)
		Actin-binding	657..679		19/21 (90%)
		Actin-binding	759..773		11/13 (85%)
		Calmodulin-binding. /evidence=ECO:0000250	790..807		11/16 (69%)
		Calmodulin-binding. /evidence=ECO:0000250	816..833		12/16 (75%)
		Myosin_tail_1	848..1925	CDD:396244	813/1076 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1908..1939		24/30 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41153at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820