DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH13 and Myh3

DIOPT Version :9

Sequence 1:	NP_003793.2	Gene:	MYH13 / 8735	HGNCID:	7571	Length:	1938	Species:	Homo sapiens
Sequence 2:	NP_036736.1	Gene:	Myh3 / 24583	RGDID:	3138	Length:	1940	Species:	Rattus norvegicus

Alignment Length:	1938	Identity:	1540/1938 - (79%)
Similarity:	1752/1938 - (90%)	Gaps:	7/1938 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTL 65
            ||||.||.:||.|||:|||.|||||||||:|||:|..|||.|:||.|.||.|::.::.||.|:|.
  Rat     1 MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETE 65

Human    66 DDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYK 130
            |:|.|.:..:.|:.||||||||||||||:|||:|||||||||:||.:||||||||||||||||||
  Rat    66 DNRTLVVKPEDVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYK 130

Human   131 WLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQY 195
            |||||.||||..||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   131 WLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQY 195

Human   196 FATIAVTGD--KKKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 258
            |||||.|||  |||::   ||:||||||||.|||||||||||||||||||||||||||||||.||
  Rat   196 FATIAATGDLAKKKDS---KMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257

Human   259 KLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVA 323
            |||||||||||||||||||||.:||||||||||:||||||||:||||:|||:|:||:||||:.||
  Rat   258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVA 322

Human   324 SIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGY 388
            ||||.|||||||:|||||||:.|||.|:||||||||||||||||||||||||||||||||||..|
  Rat   323 SIDDREELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAY 387

Human   389 LMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQ 453
            ||||||:::||.||.||||||||||||||.|.||.::|.||:|:||||:|||||||||||||||.
  Rat   388 LMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKL 452

Human   454 PRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMD 518
            |||:|||||||||||||::||||||||||||||||||||||||||||||||||||||.|||||||
  Rat   453 PRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMD 517

Human   519 LAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVH 583
            |||||||||||||||||||||||||||||||||||||||||||||||||||..||||||||||:|
  Rat   518 LAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGKAEAHFSLIH 582

Human   584 YAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSF 648
            |||||||:::|||:||||||||||||||||||.:||:.|::.:  |.|...||.||..|||||||
  Rat   583 YAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF--ATTDADGGKKKVAKKKGSSF 645

Human   649 QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGF 713
            |||||:|||||||||:|||:||||||||:|||||||||.|:|.||:|||||||||||||||||||
  Rat   646 QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGF 710

Human   714 PSRILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLE 778
            |:||||.|||||||:|||||||||||||||.|.||||.|||:|..|::||:|||||||||||.||
  Rat   711 PNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLE 775

Human   779 EMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPL 843
            |||||:|..|:|.|||||||:||||||:|||:||:||||||||||:||||||||||.||||||||
  Rat   776 EMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPL 840

Human   844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER 908
            |||||.|||||||||:|::||:|||:|||:|||||||:|:|:|||||||||||:|:|||:|||||
  Rat   841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEER 905

Human   909 CEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
            |:.|||:|..||||:||:|||.|:|||:|:||.||||.|||:||.||:|||||||||.|||||||
  Rat   906 CDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 970

Human   974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
            |||||||||:||:..|:|.|:|||:|||:|||||||||||||.||||||.|.|:.:|||||.|||
  Rat   971 ATENKVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDL 1035

Human  1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
            |.|||||||||.||||.|||||||||::||||:||||||||::|:||||:||.||||:|::|||.
  Rat  1036 ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQT 1100

Human  1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
            .|||.|||||||||||||||||||||...|||.||||||.||||||:|||||||.|.||.|||:|
  Rat  1101 LSLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELN 1165

Human  1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
            |||||||.|:||||||||||||||.||||||.|||.|||.|||||||||||||||||||.|:|||
  Rat  1166 KKREAEFLKLRRDLEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEID 1230

Human  1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
            |::|::|::||||:|:|:.|||:|||.||.:.|:|:..:.:.:|..||:||||:.||||.::|||
  Rat  1231 DLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQKSRLQTEAGELSRQLEEK 1295

Human  1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
            ||::|||::||||.|||:||||||:|||.|||||:|||||||||||||||||||||||.||||||
  Rat  1296 ESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360

Human  1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
            |||||||||||||||||||||||||||||||||||||||::||..|..|:|||||||||||||||
  Rat  1361 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425

Human  1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE 1493
            |||||.|:||:::..|.||||||||||||||||.|.:|||||||||.||||||||||||::||||
  Rat  1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYE 1490

Human  1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
            |.:|||||::||||||::||:||||||||.||::.|.||::|.:|.||:|:|:||||.|.:||||
  Rat  1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHE 1555

Human  1559 ESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
            |:||||:||||:|||||:|||:.||||||||||||.||..|.:|..||||:||||:|:|||||||
  Rat  1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKME 1620

Human  1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEE 1688
            |||||:||||.|:|||.|||.||||:|||||||:|||||||||..|||||||||||||..||..|
  Rat  1621 GDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1685

Human  1689 LEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753
            :||::..||||||.|:|:||||||:::||||||:||||||:||||||.|:.|.|:|||::.:::|
  Rat  1686 VEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVEDASRDAR 1750

Human  1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1751 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1815

Human  1819 LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK 1883
            ||.|:||||.||:.||||..|::||..||||:|||:|||:|||.||:|||||||||||.||||||
  Rat  1816 LETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYK 1880

Human  1884 RQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKM 1936
            ||||||:||||..|::.|:.|||||||.||||||||||||||||:||..|.:|
  Rat  1881 RQAEEADEQANVHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRM 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	36..73	CDD:280832	17/36 (47%)
		Myosin_head	88..770	CDD:278492	582/683 (85%)
		MYSc_Myh13	100..770	CDD:276887	572/671 (85%)
		Actin-binding. /evidence=ECO:0000250	659..681		18/21 (86%)
		Actin-binding. /evidence=ECO:0000250	761..775		11/13 (85%)
		Myosin_tail_1	850..1927	CDD:279860	831/1076 (77%)
		RILP-like	<1273..1399	CDD:304877	103/125 (82%)
		TMPIT	1744..>1837	CDD:285135	81/92 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1917..1938		15/20 (75%)
Myh3	NP_036736.1	Myosin_N	36..73	CDD:280832	17/36 (47%)
		Myosin_head	88..767	CDD:278492	582/683 (85%)
		MYSc_Myh3	100..767	CDD:276878	572/671 (85%)
		Actin-binding	656..678		18/21 (86%)
		Actin-binding	758..772		11/13 (85%)
		GrpE	843..>962	CDD:295646	89/118 (75%)
		Myosin_tail_1	847..1924	CDD:279860	831/1076 (77%)
		RILP-like	962..1095	CDD:304877	103/132 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1289		11/28 (39%)
		MIT_CorA-like	<1296..>1408	CDD:294313	97/111 (87%)
		COG6	1373..>1506	CDD:303003	107/132 (81%)
		TMPIT	1739..>1828	CDD:285135	78/88 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12270at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820