DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH13 and LOC100495968

DIOPT Version :9

Sequence 1:	NP_003793.2	Gene:	MYH13 / 8735	HGNCID:	7571	Length:	1938	Species:	Homo sapiens
Sequence 2:	XP_002935256.2	Gene:	LOC100495968 / 100495968	-ID:	-	Length:	1941	Species:	Xenopus tropicalis

Alignment Length:	1940	Identity:	1484/1940 - (76%)
Similarity:	1705/1940 - (87%)	Gaps:	2/1940 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTL 65
            ||.|||||:|||||.:|||.|||||||||:|||:|...::.|...::|||.|..|:.||:.|||.
Frog     1 MSGDAEMAVFGEAASFLRKSEKERIEAQNKPFDAKNTVYIDDTNTLFVKGFITARDGDKITVKTE 65

Human    66 DDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYK 130
            |.|..|:...|::..||||:||||||||||||:||:||:|||||||||||||||||||:||||||
Frog    66 DGRTETVTESQIYQQNPPKYDKIEDMAMMTHLNEPSVLFNLKERYAAWMIYTYSGLFCITVNPYK 130

Human   131 WLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQY 195
            |||||.|||||.||||||.|||||||||||||||.|||||:|||:||||||||||||||||||||
Frog   131 WLPVYNPEVVAGYRGKKRVEAPPHIFSISDNAYQSMLTDRENQSVLITGESGAGKTVNTKRVIQY 195

Human   196 FATIAVTGDK-KKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 259
            |||:|..||. ||:.....::||||||||||||||||||||||:|||||||||||||||||.|||
Frog   196 FATVAAIGDAGKKKQADNNLKGTLEDQIIQANPLLEAFGNAKTLRNDNSSRFGKFIRIHFGTTGK 260

Human   260 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVAS 324
            |:|||||||||||||||||||:||||||||||::||.||||::||::|||:|:|.:||||:.|.|
Frog   261 LSSADIETYLLEKSRVTFQLSAERSYHIFYQILTNKIPELIEMLLLTTNPYDYPTISQGELKVKS 325

Human   325 IDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYL 389
            |||.:|.:||::||::|||::||:|.|||:||||||:||||||||||||||||||||||||..||
Frog   326 IDDEDEFMATESAIEVLGFNAEERVSIYKMTGAVMHHGNMKFKQKQREEQAEPDGTEVADKISYL 390

Human   390 MGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQP 454
            ||||||::||.||.||||||||:|||.|.|.||.||||||.|:||||:|||||||||||||||||
Frog   391 MGLNSADLLKALCYPRVKVGNEFVTKSQTVPQVCNSVGALCKSVYEKLFLWMVTRINQQLDTKQP 455

Human   455 RQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDL 519
            ||:||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
Frog   456 RQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVQEQEEYKKEGIEWEFIDFGMDL 520

Human   520 AACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHY 584
            |||||||||||||||||||||||||||:||||||||:|||||..||:||||.|||||||||||||
Frog   521 AACIELIEKPMGIFSILEEECMFPKATETSFKNKLYEQHLGKCKNFEKPKPGKGKAEAHFSLVHY 585

Human   585 AGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGG-KKKGSSF 648
            ||.|||||:|||||||||||::||.||||||:||||||:|:||.|::|....||.|| |||||||
Frog   586 AGIVDYNISGWLDKNKDPLNDSVVQLYQKSSVKLLSFLYSSYASADSGSDSSSKGGGKKKKGSSF 650

Human   649 QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGF 713
            ||||||||||||||||||||||||||||||||||||||:||:||::|||||||||||||||.|||
Frog   651 QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGIMDNYLIIHQLRCNGVLEGIRICTKGF 715

Human   714 PSRILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLE 778
            ||||.|.||||||:||||||||:|||||||.|:||||.|||||..|:|||:|||||||||||.||
Frog   716 PSRIQYGDFKQRYKILNASAIPDGQFIDSKKAAEKLLGSIDVDHNQYRFGHTKVFFKAGLLGTLE 780

Human   779 EMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPL 843
            |||||.|..::|..|:.|||||||:|||||..||:::|.||||:||||||||||||.|:||||||
Frog   781 EMRDEMLAHVITRIQSYCRGYLMRIEFKKMNSRREALFVIQYNLRSFMNVKHWPWMKLYFKIKPL 845

Human   844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER 908
            |||||.|||||.:||::|:.||.|.::|||:||||||||.||||||||.||.|:|:|.|.|||||
Frog   846 LKSAETEKEMANIKEEYEKIKEALEKAEARKKELEEKMVVLLQEKNDLMLQAQAESETLADAEER 910

Human   909 CEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
            ||.|||.||.||:|:||:|||||:|||.|:||.||||.|||:||.||:|||:||:||:|||||||
Frog   911 CESLIKGKIQLESKIKEMTERLEDEEESNAELSAKKRKLEDECSELKKDIDELEITLSKVEKEKH 975

Human   974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
            |||||||||:|:|.||::||||:|||||||||||||||||||.||||||.|.|..:|||||.|||
Frog   976 ATENKVKNLTEDMAALDDNISKVTKEKKSLQEAHQQTLDDLQTEEDKVNTLSKAKSKLEQQVDDL 1040

Human  1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
            |||||||||||.||||.|||||.|||::||:::|.||||||.||:||||::|:|||.:||:|||.
Frog  1041 EGSLEQEKKLRLDLERTKRKLECDLKLTQETVLDFENDKQQAEERLKKKDYEISQLLSKIEDEQA 1105

Human  1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
            .|.|.||||||||||.||||||||||.|:|||.||||:.:.|||||||||||||.|||:.|||||
Frog  1106 LSSQLQKKIKELQARTEELEEEIEAERTVRAKAEKQRALITRELEEISERLEEAGGATAVQIEMN 1170

Human  1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
            ||||.||||||||||||.|:||..|..||||.||:|||||||:|||||:||||||||||||||||
Frog  1171 KKRENEFQKMRRDLEEANLRHETIACNLRKKHADTVAELGEQLDNLQRIKQKLEKEKSELKMEID 1235

Human  1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
            |.|||::..||.|:|.|:....:|||.||.|||.|:|.:|::||...||||.::|||||.:.|||
Frog  1236 DFASNLDNTSKLKANFEKLNHVLEDQLSEAKAKGEEQQRLLNDLTTHKARLLSENGELSRQGEEK 1300

Human  1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
            |||||||::.|||..||:||||||:|||||||||:|||:||:||||||||||:|||||||:||||
Frog  1301 ESLISQLSRGKQAFIQQIEELKRQLEEETKAKNALAHAVQSARHDCDLLREQFEEEQEAKSELQR 1365

Human  1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
            :|||||:||:|||.||||||||||||||||||||||.|||||:.....|||||||||||||||.|
Frog  1366 SLSKANNEVSQWRNKYETDAIQRTEELEEAKKKLAQHLQEAEDQVAAVNSKCASLEKTKQRLQSE 1430

Human  1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE 1493
            |:|||.|:|||:.|.|.||||||||||||.|||||..|.|||||||.||.||||||:||||||||
Frog  1431 VDDLMIDVERSNNAAAALDKKQRNFDKVLVEWKQKYGEGQAELEAALKECRSLSTEIFKMRNAYE 1495

Human  1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
            |.::..|||:|||||||:||:||||.|.|:||::.|.:|.:|.|||:|:::|.||||.|||||||
Frog  1496 EALELTETLKRENKNLQQEITDLTEHIGESGKSINELDKARKQVEQQKNEMQAALEEAEGSLEHE 1560

Human  1559 ESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
            |:|.||:||||:|||||:|:|:.||||||||||||:|||.:.||:.||:||||||:|||||||||
Frog  1561 ETKFLRIQLELNQVKSEMDKKIAEKDEEIEQLKRNNQRATDTLQTTLDSEIRSRNEALRLKKKME 1625

Human  1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEE 1688
            |||||:||||..:|||.||.||.||.||.|.||:.|.||:..|...|||||:|::|||..|.|.|
Frog  1626 GDLNELEIQLNQANRQAAEAQKQLRNVQTQNKDTLLQLDNKERIESDLKEQIAVLERRTALQLAE 1690

Human  1689 LEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753
            :||::.|||..:|:.:::||||.|:|:|:|||.|.||||.|:|||||:|::|.|:|||.||||:|
Frog  1691 IEEIRAALEMLDRSCKVAEQELADSSERLQLLRSHNTSLTNSKKKLESDVSQLQSEVEESIQEAR 1755

Human  1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
            |.||||||||||||:|||||||||||||||.|||||||||||||||||||||||||||||||:||
Frog  1756 NTEEKAKKAITDAALMAEELKKEQDTSAHLVRMKKNLEQTVKDLQHRLDEAEQLALKGGKKQLQK 1820

Human  1819 LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK 1883
            ||.|||||||||:.|||||.||:||..||||::||:|||.|||.||:|||||||||||.|||:||
Frog  1821 LETRVRELENELENEQKRGVEAVKGVRKYERRMKELTYQNEEDRKNVLRLQDLVDKLQLKVKAYK 1885

Human  1884 RQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
            |||||||||||..::|.|::||||.||.||||||:||||||||||||:||:|..|
Frog  1886 RQAEEAEEQANAHMARYRKMQHELGEAEERADIADSQVNKLRAKSRDIGSKKDSE 1940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	36..73	CDD:280832	14/36 (39%)
		Myosin_head	88..770	CDD:278492	573/683 (84%)
		MYSc_Myh13	100..770	CDD:276887	562/671 (84%)
		Actin-binding. /evidence=ECO:0000250	659..681		21/21 (100%)
		Actin-binding. /evidence=ECO:0000250	761..775		12/13 (92%)
		Myosin_tail_1	850..1927	CDD:279860	793/1076 (74%)
		RILP-like	<1273..1399	CDD:304877	98/125 (78%)
		TMPIT	1744..>1837	CDD:285135	83/92 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1917..1938		16/20 (80%)
LOC100495968	XP_002935256.2	Myosin_N	38..72	CDD:280832	13/33 (39%)
		Myosin_head	88..772	CDD:278492	573/683 (84%)
		MYSc_class_II	100..772	CDD:276951	562/671 (84%)
		Myosin_tail_1	852..1929	CDD:279860	793/1076 (74%)
		Uso1_p115_C	902..1007	CDD:282695	79/104 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12270at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020