DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH13 and myhz1.3

DIOPT Version :9

Sequence 1:	NP_003793.2	Gene:	MYH13 / 8735	HGNCID:	7571	Length:	1938	Species:	Homo sapiens
Sequence 2:	XP_001924014.2	Gene:	myhz1.3 / 100008070	ZFINID:	ZDB-GENE-070705-74	Length:	1937	Species:	Danio rerio

Alignment Length:	1937	Identity:	1543/1937 - (79%)
Similarity:	1746/1937 - (90%)	Gaps:	6/1937 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTL 65
            ||:|||||::|:||.||||||||||||||:|||:|.||:|.|:||:||||.|::|:..||.|.||
Zfish     1 MSTDAEMAVYGKAAIYLRKPEKERIEAQNKPFDAKTACYVVDDKELYVKGTIKSRDGGKVTVITL 65

Human    66 DDR-MLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPY 129
            |.: ......|.|.|||||||||||||||||||:||:||||||||||||||||||||||.|||||
Zfish    66 DTKEERVAKEDDVHPMNPPKFDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPY 130

Human   130 KWLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQ 194
            ||||||..|||||||||||.||||||||:||||||||||||:|||:|||||||||||||||||||
Zfish   131 KWLPVYDAEVVAAYRGKKRMEAPPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQ 195

Human   195 YFATIAVTG-DKKKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 258
            ||||:||.| :||||...|||||:||||||.|||||||:|||||||||||||||||||||||.:|
Zfish   196 YFATVAVQGPEKKKEQAAGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTSG 260

Human   259 KLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVA 323
            |||||||||||||||||||||..||.||||||:|:|.|||||::.||:|||:|||..|||::|||
Zfish   261 KLASADIETYLLEKSRVTFQLPDERGYHIFYQMMTNHKPELIEMTLITTNPYDFPMCSQGQITVA 325

Human   324 SIDDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGY 388
            ||||.|||:|||.|||||||::|||:||||.||||:|:||||||||||||||||||||.|||..|
Zfish   326 SIDDKEELVATDTAIDILGFNAEEKMGIYKFTGAVLHHGNMKFKQKQREEQAEPDGTEEADKIAY 390

Human   389 LMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQ 453
            |:|||||:|||.||.||||||||:|||||.|.||.|||.||:|::||:||||||.||||.|||||
Zfish   391 LLGLNSADMLKALCYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQ 455

Human   454 PRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMD 518
            .|.:|||||||||||||||||:|||||||||||||||||||||||||||||||||.|||||||||
Zfish   456 QRNFFIGVLDIAGFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMD 520

Human   519 LAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVH 583
            |||||||||||:|||||||||||||||||||||||||||||||.|.|||||||||||||||||||
Zfish   521 LAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKCNAFQKPKPAKGKAEAHFSLVH 585

Human   584 YAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSF 648
            |||||||||:||||||||||||:||.||||||:|||:.|:.    ....::||.||||||||.|.
Zfish   586 YAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLATLYP----PVVEETGGGKKGGKKKGGSM 646

Human   649 QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGF 713
            ||||:.|||||.|||||||||||||||||||||:||||:|:::||:|||||||||||||||||||
Zfish   647 QTVSSQFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGF 711

Human   714 PSRILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLE 778
            ||||||.||||||::||||.||||||||:|.||||||.||||:.:::|||:|||||||||||.||
Zfish   712 PSRILYGDFKQRYKVLNASVIPEGQFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLE 776

Human   779 EMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPL 843
            |||||||.:|:|.|||:||.||||.||.||||||:||:.|||||||||||||||||.:::|||||
Zfish   777 EMRDEKLASLVTMTQALCRAYLMRREFVKMMERRESIYTIQYNIRSFMNVKHWPWMKVYYKIKPL 841

Human   844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER 908
            |||||.|||:|||||||.:.||.||::||::||||||||:||||||||||.|.||:|||.|||||
Zfish   842 LKSAETEKELATMKEDFVKCKEALAKAEAKKKELEEKMVALLQEKNDLQLAVASESENLSDAEER 906

Human   909 CEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
            |||||||||.||||:||.|||||:|||:|:||.||||.|||:||.||:|||||||||.|||||||
Zfish   907 CEGLIKSKIQLEAKLKETTERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971

Human   974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
            |||||||||:|||.|.:|:|.|||||||:|||||||||||||.||||||.|.|...|||||.|||
Zfish   972 ATENKVKNLTEEMAAQDESIGKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKSKTKLEQQVDDL 1036

Human  1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
            |||||||||||.||||||||||||||::|||||||||||||.|||||||:||.|||.:||:|||.
Zfish  1037 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDLENDKQQSEEKLKKKDFETSQLLSKIEDEQS 1101

Human  1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMN 1168
            ...|.|||||||||||||||||||||...|||:||||:||:|||||||||||||.|||:||||||
Zfish  1102 LGAQLQKKIKELQARIEELEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMN 1166

Human  1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEID 1233
            |||||||||:||||||:|||||||||.||||||||||||||||||||||||||||||||.|||||
Zfish  1167 KKREAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSEYKMEID 1231

Human  1234 DMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
            |::||:||::|:|:|:|:.|||:|||.||||:|:::..:.|:||:.|:|||||:|||...::|||
Zfish  1232 DLSSNMEAVAKAKANLEKMCRTLEDQLSEIKSKNDENIRQINDLSAQRARLQTENGEFGRQLEEK 1296

Human  1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
            |:|:||||:.|||.|||:||||||:|||.|||||:|||:||:||||||||||:||||||||||||
Zfish  1297 EALVSQLTRGKQAFTQQIEELKRQIEEEVKAKNALAHAVQSARHDCDLLREQFEEEQEAKAELQR 1361

Human  1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
            .:|||||||||||||||||||||||||||:|||||||||||||..|..|||||||||||||||||
Zfish  1362 GMSKANSEVAQWRTKYETDAIQRTEELEESKKKLAQRLQEAEEQIEAVNSKCASLEKTKQRLQGE 1426

Human  1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE 1493
            |||||.|:||::...|.||||||||||||||||||.:|.|||||.||||:||||||||||:|:||
Zfish  1427 VEDLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYE 1491

Human  1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
            |.:||||||:|||||||:||||||||:.||||::.|.||:||.||.||:::|.||||.||:||||
Zfish  1492 ETLDQLETLKRENKNLQQEISDLTEQLGETGKSIHELEKSKKAVETEKAEIQTALEEAEGTLEHE 1556

Human  1559 ESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
            |||||||||||:|||||:|||:.||||||||:||||||..|::||.||:|:||||||||:|||||
Zfish  1557 ESKILRVQLELNQVKSEIDRKLAEKDEEIEQIKRNSQRVTESMQSTLDSEVRSRNDALRIKKKME 1621

Human  1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEE 1688
            ||||||||||.|:|||.||.||.||.||.||||:|||||||:|..||:|||:|:|||||.|:..|
Zfish  1622 GDLNEMEIQLSHANRQAAEAQKQLRNVQAQLKDAQLHLDDAVRGQEDMKEQVAMVERRNTLMQSE 1686

Human  1689 LEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753
            :||::.|||||||.|:::||||:|||:||.|||||||||:|||||||||:.|.|:|||:::||:|
Zfish  1687 IEELRAALEQTERGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLEADLVQIQSEVEDTVQEAR 1751

Human  1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
            ||||||||||||||||||||||||||||||||||||||.|||||||||||||.||:||||||:||
Zfish  1752 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEITVKDLQHRLDEAENLAMKGGKKQLQK 1816

Human  1819 LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK 1883
            ||:||||||.|::.||:|||:|:||..||||:|||:|||.|||.||:.||||||||||.|||:||
Zfish  1817 LESRVRELETEIEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNVNRLQDLVDKLQLKVKAYK 1881

Human  1884 RQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQK 1935
            ||:||||||||:.||:.|:||||||||.|||||||||||||||||||.|..|
Zfish  1882 RQSEEAEEQANSHLSKLRKVQHELEEAEERADIAESQVNKLRAKSRDAGKGK 1933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	36..73	CDD:280832	18/37 (49%)
		Myosin_head	88..770	CDD:278492	568/682 (83%)
		MYSc_Myh13	100..770	CDD:276887	557/670 (83%)
		Actin-binding. /evidence=ECO:0000250	659..681		20/21 (95%)
		Actin-binding. /evidence=ECO:0000250	761..775		12/13 (92%)
		Myosin_tail_1	850..1927	CDD:279860	847/1076 (79%)
		RILP-like	<1273..1399	CDD:304877	99/125 (79%)
		TMPIT	1744..>1837	CDD:285135	78/92 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1917..1938		16/19 (84%)
myhz1.3	XP_001924014.2	Myosin_N	36..74	CDD:280832	18/37 (49%)
		Myosin_head	89..768	CDD:278492	568/682 (83%)
		MYSc_class_II	101..768	CDD:276951	557/670 (83%)
		SPEC	881..1043	CDD:295325	130/161 (81%)
		Myosin_tail_1	882..1925	CDD:279860	823/1042 (79%)
		MIT_CorA-like	<1297..>1409	CDD:294313	94/111 (85%)
		TMPIT	1473..>1583	CDD:285135	83/109 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1198	1.000	Domainoid score	I239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12270at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920