DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MYH13 and myhb

DIOPT Version :9

Sequence 1:	NP_003793.2	Gene:	MYH13 / 8735	HGNCID:	7571	Length:	1938	Species:	Homo sapiens
Sequence 2:	XP_001339206.5	Gene:	myhb / 100002040	ZFINID:	ZDB-GENE-081124-1	Length:	1937	Species:	Danio rerio

Alignment Length:	1938	Identity:	1556/1938 - (80%)
Similarity:	1755/1938 - (90%)	Gaps:	2/1938 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSDAEMAIFGEAAPYLRKPEKERIEAQNRPFDSKKACFVADNKEMYVKGMIQTRENDKVIVKTL 65
            ||.|.||..||.||.||||||||||||||||||:|.|.||::.||||:||:::::|..|..|:||
Zfish     1 MSGDPEMECFGPAAVYLRKPEKERIEAQNRPFDAKTAYFVSEPKEMYLKGVLKSKEGGKATVQTL 65

Human    66 DDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYK 130
            ..:.||:..|::||||||||||||||||||||:||.|||||||||||||||||||||||||||||
Zfish    66 CGKTLTVKEDEIFPMNPPKFDKIEDMAMMTHLNEPTVLYNLKERYAAWMIYTYSGLFCVTVNPYK 130

Human   131 WLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQY 195
            |||||...||:.||||||.|||||||||||||||||||||:||||||||||||||||||||||||
Zfish   131 WLPVYDAVVVSGYRGKKRIEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQY 195

Human   196 FATIAVTGDKKKETQPGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 260
            ||||||.|.:|:|..||||||:||||||.|||||||:|||||||||||||||||||||||.||||
Zfish   196 FATIAVAGKQKQEPIPGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTTGKL 260

Human   261 ASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASI 325
            ||||||||||||||||||||:|||||||||:.:..||||::.|||:|||:|:|.:||||:||.||
Zfish   261 ASADIETYLLEKSRVTFQLSAERSYHIFYQLCTGHKPELLEALLITTNPYDYPMISQGEITVKSI 325

Human   326 DDSEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLM 390
            :|.||.:|||.|||||||::|||||||||||||||:||||||||||||||||||||||||..||:
Zfish   326 NDVEEFIATDTAIDILGFNAEEKVGIYKLTGAVMHHGNMKFKQKQREEQAEPDGTEVADKIAYLL 390

Human   391 GLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPR 455
            |||||:|||.||.||||||||:|||||.|.||.|:..||.|:||||||||||.|||:.|||||||
Zfish   391 GLNSADMLKALCYPRVKVGNEFVTKGQTVPQVNNATMALCKSVYEKMFLWMVVRINEMLDTKQPR 455

Human   456 QYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLA 520
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   456 QFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLA 520

Human   521 ACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLVHYA 585
            ||||||||||||||||||||||||||||:|||||:||||||:|.|||||||||||||||||||||
Zfish   521 ACIELIEKPMGIFSILEEECMFPKATDTTFKNKLHDQHLGKTNCFQKPKPAKGKAEAHFSLVHYA 585

Human   586 GTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSFQT 650
            |||||||:|||||||||||::||.||||||:|||..|::.:|..| .:||| ||||||||.||||
Zfish   586 GTVDYNISGWLDKNKDPLNDSVVQLYQKSSVKLLCHLYAAHASTE-AESGG-KKGGKKKGGSFQT 648

Human   651 VSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPS 715
            |||:|||||.|||||||||||||||||||||:||||:|:::||:|||||||||||||||||||||
Zfish   649 VSALFRENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPS 713

Human   716 RILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEM 780
            ||||.||||||::||||.||||||||:|.||||||.|||||..|::||:|||||||||||.||||
Zfish   714 RILYGDFKQRYKVLNASVIPEGQFIDNKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEM 778

Human   781 RDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLK 845
            ||||||.|:|.||||||||:||.||.|||.||:||:.|||||||||||||||||.|:||||||||
Zfish   779 RDEKLVILVTMTQAVCRGYVMRKEFVKMMARRESIYSIQYNIRSFMNVKHWPWMKLYFKIKPLLK 843

Human   846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
            |||.|||||.|||:||:.||:||::.|::||||||||:||||||||||||.||||||.|||||||
Zfish   844 SAETEKEMAAMKENFEKMKEDLAKALAKKKELEEKMVTLLQEKNDLQLQVASETENLSDAEERCE 908

Human   911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHAT 975
            |||||||.||||:||.|||||:|||:|:||.||||.|||:||.||:|||||||||.|||||||||
Zfish   909 GLIKSKIQLEAKLKEATERLEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973

Human   976 ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG 1040
            |||||||:||||:.:|.|.|||||||:|||||||||||||.||||||.|.|..||||||.|||||
Zfish   974 ENKVKNLTEEMTSQDEVIVKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKAKLEQQVDDLEG 1038

Human  1041 SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHS 1105
            |||||||||.||||||||||||||::|||:|||||||||:|||||||:||.||..::|:|||...
Zfish  1039 SLEQEKKLRMDLERAKRKLEGDLKLAQESLMDLENDKQQLEEKLKKKDFETSQFLSRIEDEQSLG 1103

Human  1106 LQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKK 1170
            :|||||||||||||||||||||||...|||:|||||||||||||||||||||.||||||||||||
Zfish  1104 IQFQKKIKELQARIEELEEEIEAERAARAKVEKQRSDLARELEEISERLEEAGGATSAQIEMNKK 1168

Human  1171 REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
            |||||||:||||||:|||||||||.||||||||||||||||||||||||||||||||||||:||:
Zfish  1169 REAEFQKLRRDLEESTLQHEATAAALRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEVDDV 1233

Human  1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300
            :|::||::|||:|:|:.|||:|||.||.|:|.::..:.|:||:.|||||||:|||:..::|||||
Zfish  1234 SSSMEAVAKSKTNLEKMCRTLEDQLSEFKSKHDEHVRHINDLSAQKARLQTENGEMGRQLEEKES 1298

Human  1301 LISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRAL 1365
            |:||||:||||.|||:||||||:|||.||||::|||:||||||||||||||||||||||||||::
Zfish  1299 LVSQLTRSKQAYTQQIEELKRQIEEEVKAKNSLAHAVQSSRHDCDLLREQYEEEQEAKAELQRSM 1363

Human  1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVE 1430
            |||||||||||||||||||||||||||||||||||||:|||:.|..|:|||||||||||||.|||
Zfish  1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEESIEAVNAKCASLEKTKQRLQNEVE 1428

Human  1431 DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
            |||.|:||::...|.||||||||||||||||||.:|:|||||.||||:||||||||||:|:|||.
Zfish  1429 DLMIDVERANALAANLDKKQRNFDKVLAEWKQKYEETQAELEGAQKEARSLSTELFKMKNSYEET 1493

Human  1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEES 1560
            :|.||||:|||||||:||:|||||:.||||.:.|.||.||..|.|||::|.||||.|.:||||||
Zfish  1494 LDHLETLKRENKNLQQEITDLTEQLGETGKTIHELEKGKKTAEIEKSEIQAALEEAEATLEHEES 1558

Human  1561 KILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD 1625
            |||||||||:|||.|:|||:.||||||||:||||||..:::||.||||:||||||||:|||||||
Zfish  1559 KILRVQLELNQVKGEIDRKLAEKDEEIEQIKRNSQRIIDSMQSTLDAEVRSRNDALRIKKKMEGD 1623

Human  1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELE 1690
            ||||||||.|:|||.||.||.||.|||||||:|||||:|||:.||:|||:|:|||||.|:..|:|
Zfish  1624 LNEMEIQLSHANRQAAEAQKQLRNVQGQLKDAQLHLDEALRAQEDMKEQVAMVERRNNLMQAEIE 1688

Human  1691 EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755
            |::||||||||.|:::||||:|||:||.|||||||||||||||||||:.|.|.|:|:.:||:|||
Zfish  1689 ELRVALEQTERGRKVAEQELVDASERVTLLHSQNTSLINTKKKLEADLVQIQGEMEDVVQEARNA 1753

Human  1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
            ||||||||||||||||||||||||||||||||||||.|||||||||||||.||:||||||:||||
Zfish  1754 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEVTVKDLQHRLDEAESLAMKGGKKQLQKLE 1818

Human  1821 NRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQ 1885
            .||||||:|::.||:|||:|:||..||||:|||:|||.|||.|||:||||||||||.|||:||||
Zfish  1819 ARVRELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNIIRLQDLVDKLQLKVKAYKRQ 1883

Human  1886 AEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
            :|:|||||||.|:|.|:||||||||.||||||||||||||||||:.|..|..|
Zfish  1884 SEDAEEQANTHLTRFRKVQHELEEAQERADIAESQVNKLRAKSREFGKGKEAE 1936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MYH13	NP_003793.2	Myosin_N	36..73	CDD:280832	16/36 (44%)
		Myosin_head	88..770	CDD:278492	577/681 (85%)
		MYSc_Myh13	100..770	CDD:276887	566/669 (85%)
		Actin-binding. /evidence=ECO:0000250	659..681		20/21 (95%)
		Actin-binding. /evidence=ECO:0000250	761..775		11/13 (85%)
		Myosin_tail_1	850..1927	CDD:279860	850/1076 (79%)
		RILP-like	<1273..1399	CDD:304877	104/125 (83%)
		TMPIT	1744..>1837	CDD:285135	77/92 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1917..1938		15/20 (75%)
myhb	XP_001339206.5	Myosin_N	36..73	CDD:280832	16/36 (44%)
		Myosin_head	88..768	CDD:278492	577/681 (85%)
		MYSc_class_II	100..768	CDD:276951	566/669 (85%)
		Myosin_tail_1	848..1925	CDD:279860	850/1076 (79%)
		Uso1_p115_C	898..1011	CDD:282695	92/112 (82%)
		COG6	1374..>1509	CDD:303003	108/134 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1198	1.000	Domainoid score	I239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12270at7742
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920