DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNGTT and ceg1

DIOPT Version :9

Sequence 1:	XP_016866890.1	Gene:	RNGTT / 8732	HGNCID:	10073	Length:	603	Species:	Homo sapiens
Sequence 2:	NP_595708.1	Gene:	ceg1 / 2540362	PomBaseID:	SPBC2F12.08c	Length:	402	Species:	Schizosaccharomyces pombe

Alignment Length:	405	Identity:	108/405 - (26%)
Similarity:	175/405 - (43%)	Gaps:	83/405 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   233 LEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADG 297
            :|.|:|.||  :..:..:..::.:..:..|.....|||:||||..|::::.|..|.|.|..|:||
pombe     8 IEEVSVPGV--LAPRDDVRVLKTRIAKLLGTSPDTFPGSQPVSFSKKHLQALKEKNYFVCEKSDG 70

Human   298 TRYMMLI------DGTNEVFMIDRDNSVFHVSNLEFPFRKD---LRMHLSNTLLDGEMIID-RVN 352
            .|.::.:      :....|::.||..:.:||..:.:|...|   .:.|: :||||||:::| ...
pombe    71 IRCLLYMTEHPRYENRPSVYLFDRKMNFYHVEKIFYPVENDKSGKKYHV-DTLLDGELVLDIYPG 134

Human   353 GQAVPRYLIYDIIKFNSQPVGDCD--------FNVRLQCIEREIISPRHEKMKTGLIDKTQEPFS 409
            |:...|||::|.:.        ||        .:.||....:.|..|..|..||          .
pombe   135 GKKQLRYLVFDCLA--------CDGIVYMSRLLDKRLGIFAKSIQKPLDEYTKT----------H 181

Human   410 VRNKPFFDICTSRKLLE---------GNFAKEVSHEMDGLIFQPTGDYWLFKKYKPGRCDDILKW 465
            :|....|...||.|.:|         ......:.|..|||||..|.     ..|..|....:|||
pombe   182 MRETAIFPFLTSLKKMELGHGILKLFNEVIPRLRHGNDGLIFTCTE-----TPYVSGTDQSLLKW 241

Human   466 KPPSLNSVDFRLKITRMGGEGLLPQNVGLLY-------VGGYER---------PFAQIKVTKELK 514
            ||..:|::||.||:     |...|:...:.|       :|.:|.         .:...|..::||
pombe   242 KPKEMNTIDFMLKL-----EFAQPEEGDIDYSAMPEFQLGVWEGRNMYSFFAFMYVDEKEWEKLK 301

Human   515 QYD----NKIIECKFEN-NSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCTAA 574
            .::    .:|:||..:: |.|.|:|.|.||...|..:|..:|..||.:.|:||.|.:.:.....|
pombe   302 SFNVPLSERIVECYLDDENRWRFLRFRDDKRDANHISTVKSVLQSIEDGVSKEDLLKEMPIIREA 366

Human   575 SQGQKR----KHHLD 585
            ...:|:    |..||
pombe   367 YYNRKKPSVTKRKLD 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNGTT	XP_016866890.1	None
ceg1	NP_595708.1	CEG1	1..402	CDD:227551	108/405 (27%)
		mRNA_cap_enzyme	45..242	CDD:279649	59/220 (27%)
		mRNA_cap_C	247..356	CDD:281856	31/113 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I3106
eggNOG	1	0.900	-	-		E1_COG5226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I1812
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003817
OrthoInspector	1	1.000	-	-		oto146079
orthoMCL	1	0.900	-	-		OOG6_101990
Panther	1	1.100	-	-	LDO	PTHR10367
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R688
SonicParanoid	1	1.000	-	-		X2661
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.890