Protein Alignment GBF1 and Efa6

DIOPT Version :9

• Sequence 1: XP_006718110.1
• Gene: GBF1 / 8729
• HGNCID: 4181
• Length: 1893
• Species: Homo sapiens
• Sequence 2: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Alignment Length: 676
• Identity: 143/676 - (21%)
• Similarity: 265/676 - (39%)
• Gaps: 175/676 - (25%)

Human   583 SNL----FEELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETA 643
            ||:    :::...|||..  .:.|.:..:.....|:.:.|.|:. ||.:.::...|..|::::..
  Fly   994 SNISSPDYQDDDNLLSSR--DILGGMVLSDPSDSDSTILVSDAA-AHQRQQLKQQLRAQQQQQRE 1055

Human   644 RPSCEIVDGTREASNTERTASDGKAV----GMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDS 704
            |         ....:.:|..|:.|.|    |:.|:..|    |.|    .:|:|     ||.|.:
  Fly  1056 R---------ERDRDRDREQSEHKVVIQVRGLDSNSSG----GNG----TNGRS-----EEDVVT 1098

Human   705 GADKKFA--------RKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLL 761
            ..|:...        ..||     :.|....:|          ....::..||
  Fly  1099 LTDEPLGTMTVGMRDASPP-----VSDDGSDVE----------SLHSYHYSPK------------ 1136

Human   762 TIPMDNT-EVAQWLRENPRLDKKMIGEFVSDRKNID----LLESFVSTFSFQGLRLDEALRLYLE 821
            .:.|.:. .:|:.|.......|..:...:|  ||.|    :.:.::..|:|:...||:|||.:|:
  Fly  1137 AVDMPSAIRLAKRLHSLDGFKKSDVSRHLS--KNNDFSRAVADEYLKHFTFEKKSLDQALREFLQ 1199

Human   822 AFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLE 886
            .|.|.||....:|:|..|::|:::||...|.:.||..:|..|:::||||.|..|:   |..|:..
  Fly  1200 QFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNI---NRKMSCA 1261

Human   887 EFRKNLKGVNGGKDFEQDILEDMYHAIKNE--EIVMPEEQTGLVRENYVWNVLLHRGATPEGIFL 949
            ||..||..:|.|::|.:|:|:.:|.|||.:  |..:.||...|.::....:.|.:.|..|   ||
  Fly  1262 EFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEEAGDLQQQRANNSALGNVGLNP---FL 1323

Human   950 RVPTASYDLDLFTMTWGPTIAALSY---------VFDKSLEET-------------------IIQ 986
            ..|      :|.|        |:.|         .:|.|.::|                   .:.
  Fly  1324 DPP------ELAT--------AVEYKKGYVMRKCCYDSSFKKTPFGKRSWKMFYCTLRDLVLYLH 1374

Human   987 KAISGFRKCAM-------ISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAA- 1043
            |...||||..|       |..|:.|:...::.......|...:::..|.|   |.::....:.:
  Fly  1375 KDEHGFRKSQMSDNLHNAIRIHHALATKANDYTKKQHVFRLQTADQAEYL---FQTSDSKELQSW 1436

Human  1044 -KTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLP--KAMIEVEDFVDPNGKISLQREETPSNR 1105
             :|:.::.........||.....:.    |:..|||  ::.:.:::.:|.: ::.|.:.:...|.
  Fly  1437 VETINYVCAAISAPPLEGGVGSQKR----FQRPLLPSKQSKLMLKEQLDSH-EVQLAQLDQELNE 1496

Human  1106 GESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALE-------CIKQCDPEKMITESKFLQLE 1163
            .:            .||..|  :|.:.:|.:.|...|:       ........||:.:.:.|:|:
  Fly  1497 HK------------KGPIPS--KGLALQNYKEKESYLQYELRRYRTYVSILSAKMLADQQQLELQ 1547

Human  1164 SLQELMKALVSVTPDEETYDEEDAAF 1189
            :.|          |...:::||...|
  Fly  1548 AQQ----------PSPASHEEEADTF 1563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBF1	XP_006718110.1	Sec7_N	434..579	CDD:289549
		Sec7	733..918	CDD:279680	54/191 (28%)
Efa6	NP_001163691.2	PDZ_signaling	7..85	CDD:238492
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	55/195 (28%)
		PH_EFA6	1330..1452	CDD:270107	20/132 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810