Protein Alignment GBF1 and garz

DIOPT Version :9

• Sequence 1: XP_006718110.1
• Gene: GBF1 / 8729
• HGNCID: 4181
• Length: 1893
• Species: Homo sapiens
• Sequence 2: NP_610761.2
• Gene: garz / 36337
• FlyBaseID: FBgn0264560
• Length: 1983
• Species: Drosophila melanogaster
• Alignment Length: 1970
• Identity: 842/1970 - (42%)
• Similarity: 1151/1970 - (58%)
• Gaps: 277/1970 - (14%)

Human     6 IYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSEIEPNVFLRPFLE 70
            ||:::||:..::.|::|..||:....:|:|.|.||..|..||..||.|.:|.:|||.|||.||||
  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72

Human    71 VIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMK 135
            |||:.|.|||:|.|||.||||.|||.|||||....|:.:|.:|||||||||:|||.:||.|..|:
  Fly    73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137

Human   136 ILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFK 200
            :::||.||:.:|.||.::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
  Fly   138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202

Human   201 EEPKNYVGTNMKKISPCLLNKLELSSGEQTKALNQLERVLLFKNLKLKMRAGGMSDSSKWKKQKR 265
            ||.           |..:|.| ..:.|:......|       :.||.|..|          :.:.
  Fly   203 EER-----------SDTMLQK-RFTIGDAASGATQ-------EKLKRKTVA----------QAQT 238

Human   266 SPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFS 330
            :||         ..|.:..|..|..|:|||       ||..:     :|.....:|::.:|
  Fly   239 APR---------KSSAVEEPPQTPQSANLT-------VPGHL-----KAPILATTPASPAG---- 278

Human   331 SQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQQEGTHVEKSQSASVESIPEVLEECT 395
                   ::.|::...:...:|....|..|..|||.|.:|.|.|          ||.| :|:..|
  Fly   279 -------NILDMQGKITQTPTTTASTGEDETTVPETPVIQVEST----------ESEP-LLDGET 325

Human   396 SPADHSDSASVHDMDYVNPRGVRFT-QSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEV 459
            ..|. |..|..:..:|:|..||||| ||:..:.|:|.|||||.|:|||||||.|.||.|:.||:.
  Fly   326 GEAT-STLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDS 389

Human   460 MIHMGLHLLTVALESAP--VAQCQTLLGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMR 522
            |:|.||.|||||.|.|.  :.:.:.||.|:||::||:|..|||.|||:::||.|::|||||||:|
  Fly   390 MMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLR 454

Human   523 EHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFE 587
            .|||||:|.|::||.|||..:|||.||||:|:||:.::||||||.||||||||||||.||:::||
  Fly   455 GHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFE 519

Human   588 ELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDG 652
            .||.||||.....:..:|:||::|:|.||:||||.|.:|.|. .||...:|....|.|:   ..|
  Fly   520 SLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAAS-KNSSNNRESLPEAAPA---TGG 580

Human   653 TREASNT-----------ERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGA 706
            :|.:.:.           ...|::.|...:||.|..    ...||..:.|..|.....|
  Fly   581 SRHSRHNSGLEGIVIDSGNSVAAEEKVENIASFINA----SSHRLRLQSGGEGVGITSE------ 635

Human   707 DKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVA 771
                               :|.::|.||:||..|||:|||:|:||||:|||.|:|...:|..:||
  Fly   636 -------------------QLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVA 681

Human   772 QWLRENPRLDKKMIGEFVSDRKNID--LLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQR 834
            .:|||||.||||||||::|.:||:|  :|.:||.:|.|.|||:|:|||||||.||||||||:|..
  Fly   682 LFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFL 746

Human   835 LLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGK 899
            :||.|::.|...|..||||.||.|.||||:||||.||||.|.::.|.|||||:|.|||:|:|||:
  Fly   747 VLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGE 811

Human   900 DFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIFLRVPTASYDLDLFTMT 964
            ||:|::|..:::||||||||||.||||||||||.|.|||.||.|.:|.|..|..||||:::|.:.
  Fly   812 DFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIV 876

Human   965 WGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENL 1029
            ||.:::|||::|||| .||..|:.::||.|.|.|||||.|...||.|:::|||||.|.|...::.
  Fly   877 WGASLSALSFMFDKS-TETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHE 940

Human  1030 PSV----------FGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEV 1084
            |:.          ||.|.||..|.:|||.|.|.:||.|||.||:|::..|||||.:||||::|||
  Fly   941 PAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEV 1005

Human  1085 EDFVDPNGKISLQREETPSNRGE----STVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECI 1145
            |||.:.|||..|..|: |..:.|    |::.||:|        ....|.|:.|.|:..::..:||
  Fly  1006 EDFCEANGKAMLILEK-PREKQESGLFSSLYSFIS--------SEGQREPTYEEQDFIKLGRKCI 1061

Human  1146 KQCDPEKMITESKFLQLESLQELMKALVSVTPDEE-------TYDEEDAAFCLEMLLRIVLENRD 1203
            |:|..::|:.||||:||||||||:|.::::....:       .|.|:...|.:|.|::||:.|||
  Fly  1062 KECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRD 1126

Human  1204 RVGCVWQTVRDHLYHLCVQAQD--FCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKP 1266
            |:..:|..|||.:|.|.:.:..  :.:|:.|.:|.:|:|||.|:|.||:...||.||::||::||
  Fly  1127 RMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKP 1191

Human  1267 SVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPP----AAL----QATARA 1323
            ::|.|:|.|::.|::|||||:|.||||..||..:|.||||:|:|..||    |.|    ..:|::
  Fly  1192 ALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDAQLPLPPNGSAKS 1256

Human  1324 DAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDV 1388
            |...:|.:..:.:|         :||||||||:......|.....||       ..|::|...|.
  Fly  1257 DGAISGEEDATAVP---------ERGYTSDSEITKASAAPAVSSPSA-------ENWILVNNKDS 1305

Human  1389 D-------NSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFE 1446
            :       .|.|..|.|..:.|:....|   ||..|.   :|.||.:||:||||..|||||.|||
  Fly  1306 ELTTASRPQSPPSLSAPPVNTLVYNCQL---LDHAPF---ALFKCWDSLAFIVRSVAHITPYNFE 1364

Human  1447 LCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLRRPRTSSQHAS------R 1505
            .||:.:||||||..:||.:.:.|...:.|..|.    ||:|:     |:|..:|..:|      .
  Fly  1365 ACVRCIRIFVEACRDGGIRQRRKLESAAKQKSS----KKRSE-----RKPGMASSASSSNLTLLT 1420

Human  1506 GGQSDDD------EDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKI 1564
            |..||:.      |.|.:...|..:|:|    |||||:||:||.|.|:..||||       |..:
  Fly  1421 GDPSDNQINGNAAEQEDLAQRYEQLSIQ----LLDLMYTLYTRTAQIFRWWAEE-------GCTV 1474

Human  1565 EADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYL-QRALLVHDLQKLDALEWESCFNKVLF 1628
             ..|..||:..|||||||||.|..|.||:||..|::.| ||||||||||.|...||.|||::|||
  Fly  1475 -PQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLF 1538

Human  1629 PLLTKLLENISPA---DVGGMEETRMRASTLLSKVFLQHLSPLLSL-STFAALWLTILDFMDKYM 1689
            |||.:||...:.|   |...:||:|:|.:|::||||||||:.|:.| :.|..|||.|||:::::|
  Fly  1539 PLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFM 1603

Human  1690 HAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELF--- 1751
            ..| ||.|||.:.|.||||||||.:..:||:.|  |....||||:||.||..|||:|::|||
  Fly  1604 KVG-SDTLSEQMQEILKNMLLVMHSVRVFHNQD--GSLQQALWELTWRRIGEFLPNLKEELFHDE 1665

Human  1752 --KQTVIQDPMPM-----EPQGQKPLASAHLTSAAGDTRTPGH-----PPPPEIPSELGACDFEK 1804
              :...:.:|.|.     .||.|.|.    :|.....|:....     |.||.....||:    .
  Fly  1666 GKRAQTLTNPAPQAAVAAAPQQQLPA----VTILPRQTQVSNELVVSAPTPPAATPLLGS----P 1722

Human  1805 PESPRAASSSSPGSPVA----SSPSRLSPTPDGPPPLAQPPLILQPLASPLQVGVPPMT-LPIIL 1864
            .||||.:....|  |:|    ..||.:...|...||  |||.:..|        :||.| ||.::
  Fly  1723 VESPRRSIILQP--PMADVLQQPPSFVFAQPIIVPP--QPPAVTDP--------IPPSTLLPDLV 1775

Human  1865 NPALIEATSPVPLLATPRPT 1884
            |    |||:......|..||
  Fly  1776 N----EATAAAVQATTTSPT 1791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBF1	XP_006718110.1	Sec7_N	434..579	CDD:289549	91/146 (62%)
		Sec7	733..918	CDD:279680	113/186 (61%)
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	372/758 (49%)
		Sec7_N	370..512	CDD:289549	88/141 (62%)
		Sec7	643..830	CDD:279680	113/186 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148866
Domainoid	1	1.000	637	1.000	Domainoid score	I168
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37897
Inparanoid	1	1.050	1346	1.000	Inparanoid score	I144
Isobase	1	0.950	-	0	Normalized mean entropy	S3208
OMA	1	1.010	-	-		QHG55524
OrthoDB	1	1.010	-	-		D49474at33208
OrthoFinder	1	1.000	-	-		FOG0003083
OrthoInspector	1	1.000	-	-		oto90706
orthoMCL	1	0.900	-	-		OOG6_102130
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2128
SonicParanoid	1	1.000	-	-		X2055
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750