Protein Alignment GBF1 and Sec71

DIOPT Version :9

• Sequence 1: XP_006718110.1
• Gene: GBF1 / 8729
• HGNCID: 4181
• Length: 1893
• Species: Homo sapiens
• Sequence 2: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Alignment Length: 1892
• Identity: 399/1892 - (21%)
• Similarity: 692/1892 - (36%)
• Gaps: 624/1892 - (32%)

Human     4 KNIYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSE---------- 58
            |.::|::....|:.   .::.|.|.|:.|.:..|..|.   .:|..|.|..:::|
  Fly     9 KEMFIVRALEKILA---DKDIRRSHHSQLKKSCDSALE---QIKAELISAGQIAEGNELPCAALP 67

Human    59 ---------IEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMAD 114
                     |....:..||....:|......:|  ||..:.|.::|..:..:.:.:|.....:.|
  Fly    68 LPKNDAASIINAETYFLPFELACKSRSPRIVVT--ALDCLQKLIAYGHLTGSIQDSANPGHLLID 130

Human   115 AVT---HARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEI----MQSCFRICFEMR 172
            .:.   :..|.|  |.:||.|.::|::.|.|:        :|::.| ||    :....|.|:::.
  Fly   131 RIVVTIYGCFSG--PQTDEAVQLQIIKALLTV--------VTSQHV-EIHEFTLLQAVRTCYDIY 184

Human   173 LSE---LLRKSAEHTLVDMVQLLFTRLPQFKEEPKNYVGTNMKKISPCLLNKLELSSGEQTKALN 234
            ||.   :.:.:|..||..|:.::|.|:.                                    |
  Fly   185 LSSKNLVNQTTARATLTQMLNVIFARME------------------------------------N 213

Human   235 QLERVLLFKNLKLKMRAGGMSDSSKWKKQKRSPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMP 299
            |:                                           .|||.||     ||.|.|
  Fly   214 QV-------------------------------------------YELPPPN-----SNPTNG-- 228

Human   300 FIDVPTPISSASSEAASAVVSPSTDSGLEFSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVP 364
                     |..||..:.    |.:..|..|.:..:.|.|.::.   |..|:.|.:...| :|.|
  Fly   229 ---------SIHSEDCNG----SGEESLRDSDEVIASELLAEII---SAAYNEAMKDQES-VGEP 276

Human   365 EQPDLQQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVH-DMDYVNPRGVRFTQSSQKEGT 428
            | |.|..                    .:.:|.:|| ||..:| :.|.|..  .:||...||:..
  Fly   277 E-PTLNG--------------------NDYSSHSDH-DSVELHSENDAVVT--AKFTHILQKDAF 317

Human   429 ALVPYGLPCIRELFRFLISLT-------NPHDRHNSEVMIHMGLHLLTVALESA-PVAQC-QTLL 484
            .           :||.|..|:       :|..:.:......:.||||.:.|::| ||.:. :..:
  Fly   318 L-----------VFRALCKLSMKPLPDGHPDPKSHELRSKVLSLHLLLLILQNAGPVFRSNEMFI 371

Human   485 GLIKDEMCRHLFQLLSIERLNL----YAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENP 545
            ..||..:|    ..||...::|    :..||.:...|..:.:.|||.|:|::.|::. :..:|..
  Fly   372 MAIKQYLC----VALSNNGVSLVPEVFELSLSIFVALLSNFKVHLKRQIEVFFKEIF-LNILEAN 431

Human   546 KMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEELTKLLSK----------NAFPV 600
            ...:|.|.|.::|:.::......|.::|:|||||:..:||||.|...|||          .|.|:
  Fly   432 SSSFEHKWMVIQALTRICADAQSVVDIYVNYDCDFSAANLFERLVNDLSKIAQGRQALELGANPM 496

Human   601 SGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVD-GTREASNTERTAS 664
              |..:..:..|:            |...:|..:.:..|.....|:..:.. ..:..::||:..:
  Fly   497 --QEKSMRIRGLE------------CLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQDQA 547

Human   665 DGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPD-PRELI 728
            |       :.|..:|             ||.|   .:::|..::            |.| |..|.
  Fly   548 D-------TTIQTMH-------------SGSS---HSLNSNQEQ------------LQDLPEALE 577

Human   729 EIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFV--SD 791
            |.|.:|:::.||.|.||:||:||:||||||.||.....  ::|:||.|:.||||.:||.::  :|
  Fly   578 ERKMRKEVMETGIELFNRKPQKGVQFLQEKQLLGATCG--DIARWLHEDERLDKTVIGNYIGEND 640

Human   792 RKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCN--GSPFANS 854
            ..:.:::.:::..|.|:.:.:..|||..||.|||||||..|.||:|.|..|:..||  ...|.::
  Fly   641 DHSKEVMCAYIDAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSA 705

Human   855 DACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGK-DFEQDILEDMYHAIKNEEI 918
            |..:.||:::|||.||.|:..|:.:   ||.|::.|..:|::..| |..::.|..:|..|...||
  Fly   706 DTVYVLAFSIIMLTTDLHSPQVKHK---MTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEI 767

Human   919 VMPEEQTGLV---------------RENYVWNV-----------LLHRGATPEGIFLRVPTASYD 957
            .| :..:|::               |...:||:           |:...:..:..|.......:.
  Fly   768 KM-KNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTATNLMQSVSHVKSPFTSAKHLEHV 831

Human   958 LDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALS 1022
            ..:|.|.|.|.:||.|.......:..|....:.|.|....|:..:.:|...|..:.:|.:||.|:
  Fly   832 RPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARFTLLN 896

Human  1023 SES------IENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQL---------F 1072
            :.|      .:|:.::           ||:..:||..|:.|...|.:|::.:.||         .
  Fly   897 ANSPINEMKAKNIDTI-----------KTLIMVAHTDGNYLGSSWLDIVKCISQLELAQLIGTGV 950

Human  1073 RAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEA 1137
            |.|.|..|...::|.::|:.|         .:.||::..|.|
  Fly   951 RPQFLSGAQTTLKDSLNPSVK---------EHIGETSSQSVV----------------------- 983

Human  1138 KRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENR 1202
              ||:        :::.|.|..|..:::.:.:|||..|:.| |...::...|.|:.::.|...|.
  Fly   984 --VAV--------DRIFTGSMRLDGDAIVDFVKALCQVSVD-ELQQQQPRMFSLQKIVEISYYNM 1037

Human  1203 DRV----GCVWQTVRDHLYHL-CVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILL 1262
            :|:    ..:||.:.:|...: |...::..|.   |:..|.:|:::.:.:.|.|     :.|...
  Fly  1038 ERIRLQWSRIWQVLGEHFNAVGCNSNEEISFF---ALDSLRQLSMKFMEKGEFS-----NFRFQK 1094

Human  1263 --------LMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPAALQA 1319
                    :||.:....:...|...:.:::.:.|.||.||  |..:|::...
  Fly  1095 DFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSG--WKNIFSIFHL------------- 1144

Human  1320 TARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVG 1384
                      |..|:|.|                                     :|...:...|
  Fly  1145 ----------AAGDNEEP-------------------------------------IVELAFQTTG 1162

Human  1385 KDDVDNSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCV 1449
            |...|..|            .|:::.|                               |:|:..|
  Fly  1163 KIIGDLYK------------RQFAIMV-------------------------------DSFQDAV 1184

Human  1450 KTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLRR---------PRTSSQHASR 1505
            |.|..|..|                       ||...|.|...|.|         |:..::||
  Fly  1185 KCLSEFATA-----------------------RFPDTSMEAIRLVRTCAQCVHEAPQLFAEHA-- 1224

Human  1506 GGQSDDDEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRT 1570
             |..:|                                    :|.|||.|
  Fly  1225 -GMEND------------------------------------ASVAEEDR--------------- 1237

Human  1571 LWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLL--TK 1633
            :|...|.|:|..::|:....:..||.:|||.|...:..:. :......|:..|| |:|.:.  .|
  Fly  1238 VWVRGWFPMLFSLSCVVNRCKLDVRTRALTVLFEIVKTYG-ESFKPHWWKDLFN-VIFRIFDNMK 1300

Human  1634 LLENISPADVGGMEETRMRASTLLSKVFLQH---LSPLLSLSTFAAL-WLTILDFMDKYMHAGSS 1694
            |.|:::... ..|..|...|...:..||.|:   |..||....||.| |..          ..|:
  Fly  1301 LPEHVTEKS-EWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCV----------QQSN 1354

Human  1695 DLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWER-IDCFLPHLRDELFKQTVIQD 1758
            :.|:.:....|:|  ||:.....|:             |.||:: ..|.|     ::|..|:.||
  Fly  1355 EQLARSGTNCLEN--LVISNGFKFN-------------ESTWDKTCQCIL-----DIFNATLPQD 1399

Human  1759 PMPMEPQ 1765
            .:...|:
  Fly  1400 LLSWRPK 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBF1	XP_006718110.1	Sec7_N	434..579	CDD:289549	38/157 (24%)
		Sec7	733..918	CDD:279680	72/189 (38%)
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	398/1888 (21%)
		DCB	30..212	CDD:292830	42/197 (21%)
		Sec7_N	312..465	CDD:289549	40/168 (24%)
		Sec7	582..767	CDD:279680	72/189 (38%)
		DUF1981	1080..1161	CDD:286414	18/147 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750