Protein Alignment TNK1 and Ack

DIOPT Version :10

• Sequence 1: NP_001238831.1
• Gene: TNK1 / 8711
• HGNCID: 11940
• Length: 666
• Species: Homo sapiens
• Sequence 2: NP_647859.1
• Gene: Ack / 38489
• FlyBaseID: FBgn0028484
• Length: 1073
• Species: Drosophila melanogaster
• Alignment Length: 805
• Identity: 259/805 - (32%)
• Similarity: 360/805 - (44%)
• Gaps: 199/805 - (24%)

Human     9 WLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSK 73
            ||..|||::||.||...|.::|.|||..|||:|.|:||:..|:|:||.|||.||:::.::....|
  Fly    17 WLEDLLREVQLEQFLDRIRDDLQVTRLAHFDYVLPDDLERCGLGKPAIRRLMEAVRKKKAHQWRK 81

Human    74 NWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGG---LKCLIPEGAVCRGELLGSGCFGVVHRGLW 135
            |.:.|::||    .|:|:....|.......:|.   |.|||.|..:..|..||.|.||||.||.|
  Fly    82 NILSKLIGG----GKQPSSKKQSSAARESSQGNGTQLTCLIHEKDITMGLKLGDGSFGVVRRGEW 142

Human   136 TL-PSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELA 199
            :. |:||.:|||||.|:.......|. :.||.|||..|..|:|.:::||:|:||.||:.|:.|||
  Fly   143 SASPAGKVIPVAVKVLKSDNLTQPGI-IDDFFREVQAMHALDHANLVRLYGVVLSQPMMMITELA 206

Human   200 PLGSL---------HARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS 255
            ..|||         |..||           ::..:..|:...||||..:..:|||||.||:|||:
  Fly   207 ERGSLLDTLRKQCRHTSLT-----------IIWNWSVQIVTGMAYLEQKRFLHRDLACRNVLLAA 260

Human   256 PRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGG 320
            ...||:.||||:|.|......|||...:.:|:.||||||||...||.|||.||||||||||||.|
  Fly   261 GNKIKIGDFGLMRALPQEDDCYVMSEHKKVPFPWCAPESLRFRQFSHASDTWMFGVTLWEMFSFG 325

Human   321 EEPWAGVPPYLILQRLE-DRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSE 384
            |:||.|:....||:::: :..||.:|..|...:|::.|:||...||:||:|:.|:..|....|..
  Fly   326 EDPWVGLNGSQILRKIDREGERLHQPDACPPDVYAMMLQCWDKTPAERPTFAALKEYLASMSPPV 390

Human   385 ACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAV---TLADAG 446
            ....|...|...|::|.||.|.:|:|..     :..:.||||.|||.:|.||.:.:   .:..||
  Fly   391 MRASRSHHESKGLQIEPGDTIAIIDGRH-----ELKLIKGQNQRTFDIGIFPRNLLEQRKVGAAG 450

Human   447 GLPATRPVHRGTP--------------ARGDQHPGSIDGDRKKANLWDAPPARG----------- 486
            .:.....|..|:.              |.||      |..||.|::.:.|.|:.
  Fly   451 DVVMRSSVGNGSSSSPFGFCWGGAAAMANGD------DRQRKCASMTNQPHAKERKSTSSKQFAY 509

Human   487 -----------QRRNM---------------PLERMKGI------------------------SR 501
                       ||||.               |..:.:||                        |.
  Fly   510 NKLVNDSATGLQRRNAVKHKGVVVGPQRPPPPQFQQEGILIDISPDMRPIAEAGTGGAKGAGDSS 574

Human   502 SLESVLSL----GP--RPTGGGSS--------------PPEIRQARAVPQGPPGL---PP--RPP 541
            ||::..|.    .|  .||..|||              .|:.....|.....||.   ||  .||
  Fly   575 SLQADSSFCILDAPIDVPTYAGSSGSGDLNVSPTYYNEQPQFDFDPAKMTASPGRLQPPPYQMPP 639

Human   542 LSSSS-----------PQPSQPSRERLPW-------------------PKRKPPHNHPM-GMPGA 575
            ..|::           .|.:.|.|||.|:                   ....||  .|: ..|..
  Fly   640 TYSNTMEFVQKRDLHQQQLATPVRERDPFDTTNVETTVALYSNFNQSLEAASPP--APIYNSPSV 702

Human   576 RKAAALSGGLLSD----PELQRKIMEVELS-----VHGVTHQECQTALGATGGDVV----SAIRN 627
            ||  :|.||..|:    |.|:...|::.||     .|..|..:....:.|..||.|    |.|..
  Fly   703 RK--SLFGGSKSNKENIPALESAAMQLNLSNLTLERHDATCIQPVEPVPAPPGDGVLLDKSFIAE 765

Human   628 LKVDQLFHLSSRSRADCWRILEHYQ 652
            |:.|  .:.:.::||.     |.||
  Fly   766 LEKD--MYSNGQNRAQ-----EEYQ 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TNK1	NP_001238831.1	SAM_TNK-like	6..67	CDD:188938	30/57 (53%)
		PK_Tyr_Ser-Thr	116..377	CDD:462242	119/271 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..493		16/97 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..579		28/128 (22%)
		UBA_like_SF	594..637	CDD:473871	13/51 (25%)
		UBA_TNK1	624..663	CDD:270513	8/29 (28%)
Ack	NP_647859.1	SAM_TNK-like	14..75	CDD:188938	30/57 (53%)
		PTKc_Ack_like	128..385	CDD:270636	119/268 (44%)
		UBA_TNK1	1031..1070	CDD:270513