Protein Alignment TNK1 and Tnk1

DIOPT Version :10

• Sequence 1: NP_001238831.1
• Gene: TNK1 / 8711
• HGNCID: 11940
• Length: 666
• Species: Homo sapiens
• Sequence 2: XP_006246766.1
• Gene: Tnk1 / 303247
• RGDID: 1310113
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 675
• Identity: 552/675 - (81%)
• Similarity: 586/675 - (86%)
• Gaps: 19/675 - (2%)

Human     1 MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKR 65
            |||||.|||||:||||:||||||.|||||||||||||||||:|||||.:||||||||||:|||||
  Rat    74 MLPEASSLWLLRLLRDVQLAQFYRPILEELNVTRPEHFDFVRPEDLDNLGMGRPAQRRLTEALKR 138

Human    66 LRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVV 130
            .|||.||||||||||||||||.||....|||..||.|||||||||||||||||||||||||||||
  Rat   139 YRSGVKSKNWVYKILGGFAPEQKEIPPYSDSLPHLHEPEGGLKCLIPEGAVCRGELLGSGCFGVV 203

Human   131 HRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMV 195
            |:||||||.|:|:||||||||||||||||||||||||||||||.|||||||||||||||||||||
  Rat   204 HQGLWTLPGGQSIPVAVKSLRVGPEGPMGTELGDFLREVSVMMKLEHPHVLRLHGLVLGQPLQMV 268

Human   196 MELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIK 260
            ||||||||||||||||||.|||.|.|||||||||||||||||:.||||||||||||||||||.||
  Rat   269 MELAPLGSLHARLTAPAPMPPLPVTLLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRKIK 333

Human   261 VADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWA 325
            ||||||||||||||||||||||||||||||||||||.||||:|||||||||||||||||||||||
  Rat   334 VADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRQGAFSAASDVWMFGVTLWEMFSGGEEPWA 398

Human   326 GVPPYLILQRLE-DRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVR 389
            |||||||||||| ||||||:|.||||||||||||||||||||||:||:||||||||..||..|||
  Rat   399 GVPPYLILQRLEKDRARLPKPALCSRALYSLALRCWAPHPADRPTFSNLEGLLQEAWLSEGRCVR 463

Human   390 DVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPATRPV 454
            :||||||||||.|||||:|||     |||:|.||||||||.|||:||||||||||.||.|.|.||
  Rat   464 EVTEPGALRMEPGDPITIIEG-----SPDTTTWKGQNGRTLKVGNFPASAVTLADLGGSPVTHPV 523

Human   455 HRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSS 519
            |||:||||:::.|..||||:||.|.|.||||.|||.:||:||||||:||||||||||||.|||||
  Rat   524 HRGSPARGEKYRGGTDGDREKAVLQDLPPARNQRRKVPLQRMKGISKSLESVLSLGPRPAGGGSS 588

Human   520 PPEIRQ--ARAVPQG-------PPGLPPRPPLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGA 575
            |||:|:  .||.|||       ||.||||||:..|| ||.||.|.|   |||:|.|||..|.||:
  Rat   589 PPELRRGCTRAWPQGLADLPPRPPDLPPRPPIICSS-QPIQPHRVR---PKREPLHNHCTGAPGS 649

Human   576 RKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRS 640
            .|.....||.|||.|.||||:||||||||||:||||.||...||||.|||||||||||||||:||
  Rat   650 SKVTIPPGGPLSDSEWQRKIVEVELSVHGVTYQECQMALRTMGGDVASAIRNLKVDQLFHLSNRS 714

Human   641 RADCWRILEHYQWDLSAASRYVLAR 665
            ||||.|||||:.|||||||||||||
  Rat   715 RADCRRILEHHHWDLSAASRYVLAR 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TNK1	NP_001238831.1	SAM_TNK-like	6..67	CDD:188938	52/60 (87%)
		PK_Tyr_Ser-Thr	116..377	CDD:462242	243/261 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..493		29/46 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..579		49/81 (60%)
		UBA_like_SF	594..637	CDD:473871	35/42 (83%)
		UBA_TNK1	624..663	CDD:270513	34/38 (89%)
Tnk1	XP_006246766.1	SAM_TNK-like	89..140	CDD:188938	44/50 (88%)
		Protein Kinases, catalytic domain	193..453	CDD:473864	241/259 (93%)
		SH3	<468..509	CDD:473055	34/45 (76%)
		UBA_like_SF	668..711	CDD:473871	35/42 (83%)
		UBA_like_SF	698..737	CDD:473871	34/38 (89%)