DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERPINB7 and Spn88Eb

DIOPT Version :9

Sequence 1:	NP_001035237.1	Gene:	SERPINB7 / 8710	HGNCID:	13902	Length:	380	Species:	Homo sapiens
Sequence 2:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	108/403 - (26%)
Similarity:	188/403 - (46%)	Gaps:	53/403 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    10 EFCFNLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQS 74
            :|...|.:::.:...:||:|||..|.:.||.|....:.:.:..::.:.|::      |.:.|.|.
  Fly    40 DFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNL------GWALNKQQ 98

Human    75 GLQS-QLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEK----LYDAKVERVDFTNH 134
            .|.| .|.:...:........:||..|.:|.::.       |..:.|    ||.|..| :||.|.
  Fly    99 VLVSYTLAQRQDEFRWRQSPMELSSANRIFVDRT-------INVSNKFNTLLYGATKE-LDFKND 155

Human   135 LEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPK 199
            .|...:.||.|:.::||.:|::::....|:...::||.||.|.||:|.|.|...||....|...:
  Fly   156 PETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINE 220

Human   200 CSGKAVAMMHQERKFNLSVIEDPSMKILELRY----------------NGGINMYVLLPEND--- 245
            ...:.|.|||:...|.:::.|....:|::|.|                ...|:|.::||.::
  Fly   221 REQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKIS 285

Human   246 LSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDIFDESK--ADLS 308
            |:.:.::|...::.:|.  .|...:.:|:..|:|:.|:..|:...|..:|:..:|..:.  .||:
  Fly   286 LNRVISRLNADSVKKWF--ERALPQKIELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLT 348

Human   309 GIASGGRLYISRMMHKSYIEVTEEGTEATAATGSNIV----EKQLPQSTLFRADHPFLFVI--RK 367
              |....|.|....|.:.|:|.|.|:.|.|||   |:    ..:.|..|.|..:|||:|:|  .|
  Fly   349 --ADPISLVIDDAQHLAKIKVDEVGSTAAAAT---ILLVSRSSRQPDPTKFNCNHPFVFLIYDEK 408

Human   368 DDIILFSGKVSCP 380
            .|.|||:|..|.|
  Fly   409 VDTILFAGVYSDP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINB7	NP_001035237.1	serpinB7_megsin	1..380	CDD:381032	107/401 (27%)
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	106/398 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920