DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SERPINH1 and Spn42Dd

DIOPT Version :9

Sequence 1:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_001163067.1	Gene:	Spn42Dd / 49808	FlyBaseID:	FBgn0028988	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	108/374 - (28%)
Similarity:	180/374 - (48%)	Gaps:	40/374 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    54 LYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSL 118
            :||.::|....:|::||||.:.:.|.:|.:|.:.:||.:.::.|.......|.|.|..|.||..|
  Fly    21 IYQLLSKSHTNQNLVVSPVSIETILSMVFMGAEGSTAKELQSALGLPSEDKEAVAARYGALLNDL 85

Human   119 SNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDG 183
            .......:. ||.:|:|.....|...::..:.::.:..|...|:..:...|.:.||:|....|.|
  Fly    86 QGQEEGPIL-KLANRIYVNDQYSLNQNYNLAVREPFKSEAESISLTNGPVAAERINQWVLDQTSG 149

Human   184 KLP------EVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGL 242
            |:.      .:|.||:    ||||||::||..|:.||.........|.||.:.:|.|.||.:.|.
  Fly   150 KIKGMIDPGSMTSDVK----ALLVNAIYFKGQWESKFDPAKTRASTFQVTANKSVPVQMMAQMGT 210

Human   243 Y--NYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAIS 305
            :  ||:.|  ...|::|:|..:...|:.|.:|..||.|..||     |::..:...:..|.|.:.
  Fly   211 FRANYFRD--LDAQVIELPYLNSNLSMTIFLPREVEGLSALE-----EKIVGFARPLVAKEVYLK 268

Human   306 LPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRM----SGKKDLYLASVFHATAFELDTDGNPF 366
            |||..:|...:|::.|..||:.| :..:|:|||.:    ||.|   ::.|.|....|::.:|
  Fly   269 LPKFKIEFRDELKETLEKLGIRE-LFTDKSDLSGLFADKSGGK---VSQVSHKAFLEVNEEG--- 326

Human   367 DQDIYGREELRSPK------LFYADHPFIFLVRDTQSGSLLFIGRLVRP 409
             .:..|...:....      ...|||||.|::||  :.::.|.||:|.|
  Fly   327 -AEAAGATSVAVTNRAGFSTFLMADHPFAFVIRD--ANTIYFQGRVVSP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	108/374 (29%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Spn42Dd	NP_001163067.1	SERPIN	16..369	CDD:238101	105/369 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920