DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SERPINH1 and Spn88Eb

DIOPT Version :9

Sequence 1:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	102/458 - (22%)
Similarity:	174/458 - (37%)	Gaps:	90/458 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     3 SLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLA---------------- 51
            ||:||:   ||.....|.:.||..:.....::...      .||...||
  Fly     5 SLVLLA---LLPVVTIAALDKPELSFLNEFSQIFK------GERDFSLALMKQIREIYPSGNLFF 60

Human    52 --FSLYQAM-----AKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDE---- 105
              ||.|.|:     :..:..|..|      |.:|.|    |.|....|.....:..|.:||
  Fly    61 SPFSTYNALLLAYFSSSEQTEREL------AQALNL----GWALNKQQVLVSYTLAQRQDEFRWR 115

Human   106 EVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFR-DKRSA 169
            :....|....|...:.|. ||:.|..:.|||.:                    .:::|: |..:.
  Fly   116 QSPMELSSANRIFVDRTI-NVSNKFNTLLYGAT--------------------KELDFKNDPETG 159

Human   170 LQSINEWAAQTTDGKLPEVTKDVERTDGALLV--NAMFFKPHWDEKFHHKMVDNRGFMVTRSYTV 232
            |:.||:|.|..|..::.::....|.|...:||  ||.:.|..|..:|..:....:.|.:......
  Fly   160 LKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQE 224

Human   233 GVMMMHRTGLYNYYDDEKEKLQIVEMPL--------AHKLS-------SLIILMPHHVE-PLERL 281
            .|.|||:||.:....||..:.||:::|.        .|..:       |:||::|:..: .|.|:
  Fly   225 MVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRV 289

Human   282 EKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDL 346
            ...|..:.:|.|..:...:.:.:||||...|...:|...|:.:|:.....:|.......:....|
  Fly   290 ISRLNADSVKKWFERALPQKIELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLTADPISL 354

Human   347 YLASVFHATAFELDTDGNPFDQD---IYGREELR-SPKLFYADHPFIFLVRDTQSGSLLFIGRLV 407
            .:....|....::|..|:.....   :..|...: .|..|..:|||:||:.|.:..::||.|...
  Fly   355 VIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYS 419

Human   408 RPK 410
            .|:
  Fly   420 DPR 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	93/425 (22%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	92/411 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920