DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JRKL and cag

DIOPT Version :9

Sequence 1:	NP_001248762.1	Gene:	JRKL / 8690	HGNCID:	6200	Length:	524	Species:	Homo sapiens
Sequence 2:	NP_001260876.1	Gene:	cag / 36157	FlyBaseID:	FBgn0017414	Length:	225	Species:	Drosophila melanogaster

Alignment Length:	176	Identity:	49/176 - (27%)
Similarity:	90/176 - (51%)	Gaps:	17/176 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     4 KRKRVVLTIKDKLDIIKKLEDGG-SSKQLAVIYGIGETTVRDIRKNKEKIITYASSSDSTSLLAK 67
            ::.|..||:::|:::|:..|... |.:.||..:.||:|...||.|:|:. |.....|....|...
  Fly     7 RKPRTSLTLEEKMEVIQSQERNKLSVRDLAKRFNIGKTQAADILKHKQS-IKEGLLSGELKLNQM 70

Human    68 RKSMKPSMYEELDRAMLEWFNQQRAKGNPISGPICAKRAEFFFYALGMDGDFNPSAGWLTRFKQR 132
            |::.......::|....:||::.|.:..||||.:..|:|:.....|| ..:|:.|:|||.::::|
  Fly    71 RRNPLSQRGAQIDEMCFDWFSRVRTENIPISGEMVRKKAKQLAVELG-HSNFSASSGWLEKWRKR 134

Human   133 HSIREINIRNERLNGDETAVEDFCNNFRDFIERENLQPEQIYNADE 178
            |::|    .|:  .||...:::|        |...::.|.|.|.|:
  Fly   135 HNVR----YND--TGDSLDLQEF--------EAILVKSEPISNKDD 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JRKL	NP_001248762.1	HTH	4..52	CDD:304362	16/48 (33%)
		CENPB	73..139	CDD:197828	20/65 (31%)
		DDE_1	206..385	CDD:281213
cag	NP_001260876.1	CENP-B_N	7..60	CDD:282122	17/53 (32%)
cag	NP_001260876.1	CENPB	78..141	CDD:197828	20/67 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3105
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1343623at2759
OrthoFinder	1	1.000	-	-		FOG0000365
OrthoInspector	1	1.000	-	-		otm40429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820