DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRT38 and CG31533

DIOPT Version :9

Sequence 1:	NP_006762.3	Gene:	KRT38 / 8687	HGNCID:	6456	Length:	456	Species:	Homo sapiens
Sequence 2:	NP_731887.1	Gene:	CG31533 / 318788	FlyBaseID:	FBgn0051533	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	278	Identity:	53/278 - (19%)
Similarity:	95/278 - (34%)	Gaps:	107/278 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    21 RNVSVSPIDIGCQPGAEANIAPMCLLANVAHANRVRVGSTPLGRPSLCLPPTC-------HTACP 78
            |::|::|:..|         .|:.:.:::.|      |..|:....:||   |       :..||
  Fly   293 RSLSLAPVKSG---------IPVSVRSDLLH------GVKPIRFCPVCL---CSMSWMPKYAPCP 339

Human    79 LPGTCHIPGNIGICGAYGENTLNGHEKETM---QFLNDRLAN-------------YLEKVRQLEQ 127
            ...|..:|            .|.||..|.:   :.|.::|..             ..||||:...
  Fly   340 QCNTKAVP------------ILQGHPIENITAEEILAEQLVKPKAPPGVEDFCEPPCEKVRRKIW 392

Human   128 ENAELEATLLERSKCHESTVCPDYQSYFHTIEELQQKILCSKA--ENARLIVQIDNAKLAADDFR 190
            .:.|....   |..|.:...||..:     |.::...|..:|:  :..|.|.:    ..:::||.
  Fly   393 NDTECPPC---RCTCSKGNTCPHCR-----IRKMCDDIFTAKSPPKPPRRIPK----PRSSEDFC 445

Human   191 IKLESE------------RSLRQLVE----------ADKCGTQKLLDDATLAKADLEAQQESLKE 233
            :.:|||            ..|:.|..          .::|.:|.|.   |:      ..:.|:||
  Fly   446 VVMESEGEDDLPYLAKVFSELKNLYHIHDTKKLSAIKERCASQSLF---TI------RSRRSIKE 501

Human   234 EQLSL---------KSNH 242
            ...||         :|:|
  Fly   502 LTKSLYPGDKILDGRSHH 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT38	NP_006762.3	Head	1..104		17/89 (19%)
		Filament	104..414	CDD:278467	35/188 (19%)
		Coil 1A	105..139		8/49 (16%)
		Linker 1	140..150		2/9 (22%)
		Coil 1B	151..251		23/125 (18%)
		Spc24	204..>273	CDD:285486	11/58 (19%)
		Linker 12	252..267
		Coil 2	268..411
		Tail	412..456
CG31533	NP_731887.1	DUF4788	12..260	CDD:292651
CG31533	NP_731887.1	DUF4776	315..758	CDD:292622	47/241 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900