DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and si:dkey-5g14.1

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_009303600.1	Gene:	si:dkey-5g14.1 / 556497	ZFINID:	ZDB-GENE-091204-361	Length:	463	Species:	Danio rerio

Alignment Length:	494	Identity:	118/494 - (23%)
Similarity:	225/494 - (45%)	Gaps:	74/494 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VEPTMFLYMFA-FMITSVVEQNFFLYK---------SCRVNRNFTEEICRNLNKPENEEFRTKAM 113
            :||.:.:|.|| ||:..:::|  ::|:         :..|:.|.::....:.|....:|...||.
Zfish     7 IEPVVAIYAFASFMLYPLIQQ--YVYRRLWLEITNSTYPVSENTSQCAANSSNHTSRQEEVQKAA 69

  Fly   114 LTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFY--STMIVVNARMTTWPV 176
               :.|..:.::|:.:..:|:.|.|.|:||:||||:.::|.|:|...|  |.:.|...::..:
Zfish    70 ---SLFSMYTDLSSMIPSLIVTLLLVSYSDQRGRKITIIMPLIGTLIYTLSFLTVSFFQLNLY-- 129

  Fly   177 QNIIYSATLPSALTGADVAIFASCFAYISDI-SSLQQRTIRVTILDVIYLSAMPMGVA---LGSH 237
              ::..|:..|||.|....:...||:|::|: ...:|:|:|:.::|:  :..|..|||   .|..
Zfish   130 --LLIVASFVSALFGGIGTMLGGCFSYVADLCEDGKQKTLRMAVVDM--MIGMLAGVASISTGYF 190

  Fly   238 LFYNVFNQSYADMFTVNASLLALAIIYTLCALKWQTTPRQRSLRELGCCGFWGDFFDKQHVKD-- 300
            |....||..:   || :|....:.::|.:..|: :|....|| ..|.||         |.:::
Zfish   191 LHAAGFNWPF---FT-SAIFQVVNLLYAIFILE-ETRVIDRS-ETLACC---------QALRNLA 240

  Fly   301 -SLAVLVKPRKGHRRSFLIILLVSMALYTFQRDEGQYLYMYTLGKFD----WDVSAYSNFKTFKS 360
             |:..|.......|...|::|:::.:..:|....|  |.::||.:.:    | ......:.:..|
Zfish   241 CSIYSLFAGGSRRRTWVLVLLIITFSSLSFVNTGG--LSIFTLYELNEPLCW-TEILVGYGSAAS 302

  Fly   361 SAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAVVCSLGPIVGPM 425
            ::..|...:.|.|.:..|  .:..|.|||..:.:::.|...||..|..::...:......:..|:
Zfish   303 TSIFITSFVGVFLFSLCL--PNIAIAFIGMLSVAVSMLMTGFAKTTLTMFLVRIPAMFAIMPFPV 365

  Fly   426 IRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRRTQNTNHGGNVFILTIATQIAVFV 490
            :|:|.||:|..||:|.:||.::..:......|...:|::|..|.....|   |:..:...:.:..
Zfish   366 LRSMMSKVVSKSEQGALFACVAFTETLSTNGSAASFSRIYAATVAWCPG---FVFLLGAGLCLIP 427

  Fly   491 MIL-----CLHIVLGKNSLAVPEVPEKESGLISQ--TEA 522
            |.|     |:|          |..|.....|:|:  |||
Zfish   428 MSLLGILKCVH----------PLDPNDTQALLSEDGTEA 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	84/341 (25%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	92/380 (24%)
si:dkey-5g14.1	XP_009303600.1	MFS	79..435	CDD:119392	93/384 (24%)
si:dkey-5g14.1	XP_009303600.1	MFS_1	81..393	CDD:284993	84/337 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6513
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860