DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and slc46a1

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_956579.1	Gene:	slc46a1 / 393255	ZFINID:	ZDB-GENE-040426-1012	Length:	481	Species:	Danio rerio

Alignment Length:	472	Identity:	112/472 - (23%)
Similarity:	193/472 - (40%)	Gaps:	63/472 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EDNENSASGTVREQRDEAAGRTVLQWAWHVVK-----------STSVEPTMFLYMFAFMITS-VV 76
            ||::.||  .:.|..:....|||.: .:.|.:           |.:|||.|||..|:.::.: :.
Zfish     2 EDSDTSA--ILAEDSESVDSRTVCR-CFRVTENKAPPPCSCPLSVTVEPVMFLSTFSIVLQAPLC 63

  Fly    77 EQNFFLYKSCRVNRNFTEE---ICRNLNKPENEEFRTKAMLTNAWFLQWENISAHVFPIILALFL 138
            .|..:...|..|..|.|:.   ....::.|...|..|   ||..|.| :.|:...:..:.:.:.|
Zfish    64 TQYLWDRLSEDVGYNGTKTGGCNASTVHDPLQTEVET---LTAHWSL-YINLGGFLVGLFMVILL 124

  Fly   139 GSFSDRRGRKLPLL---MGL-VGKFFYSTMIVVNARMTTWPVQNIIYSATLPSALTGADVAIFAS 199
            ||:|||.||:|.|:   :|| |....|.|::.:...:..:.:..|.      |.|:|...||.|.
Zfish   125 GSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRIC------SGLSGDFNAILAG 183

  Fly   200 CFAYISDISSLQQRTIRVTILDVIYLSAMPMGVALGSHLFYNVFN------QSYADMFTVNASLL 258
            ||||::|.|....||.||.||:..      :|:|   .:|.::..      |.|.:.|.:..:..
Zfish   184 CFAYVADTSERGSRTFRVAILEAC------LGLA---GMFASIIGGQWRRAQGYINPFWLVLATN 239

  Fly   259 ALAIIYTLCALKWQTTPRQRSLRELGCCGFWGDFFDKQHVKDSLAVLVKPRKGHRRSFL-IILLV 322
            ..|.:|....:....||..::           ..|..:|.:....:........|||.| :.:|.
Zfish   240 LTAALYAYLFVPETVTPDPQA-----------RLFSTRHHQAVCRLYSSDAPPGRRSKLWLYILC 293

  Fly   323 SMALYTFQRDEGQYLYMYTL-GKFDWDVSAYSNFKTFKSSAYVIAMLLAVPLMNKILGWRDTTII 386
            ...:.|..........:|.| ....|...........|..|| :..|..:..|...|  .|:.:.
Zfish   294 FFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAY-LTSLTGLRAMQCCL--EDSWVA 355

  Fly   387 FIGTWAHSIARLFFYFATNTDLLYAGAVVCSLGPIVGPMIRAMTSKIVPTSERGKVFALLSVCDN 451
            .:|..::.:..:....|..|.|::.|..:|.|.....|::|:..||:|..:|:|.:||.::..:.
Zfish   356 LVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEG 420

  Fly   452 AVPFISGVCYSQLYRRT 468
            ....:|...::.||..|
Zfish   421 LCSLVSSGVFNALYPAT 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	78/340 (23%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	82/349 (23%)
slc46a1	NP_956579.1	MFS	93..460	CDD:119392	90/378 (24%)
slc46a1	NP_956579.1	MFS_1	114..427	CDD:284993	78/341 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6480
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860