DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42514 and CG8046

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_724761.1	Gene:	CG8046 / 35936	FlyBaseID:	FBgn0033388	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	148/556 - (26%)
Similarity:	228/556 - (41%)	Gaps:	112/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AHSEN---AAQRRN-------SRSSENSEDNENSA-------SGTVREQRDEAAGRTVLQWAWHV 53
            || ||   .|||..       |.:||....:..||       .|..:..|.::.|..:|
  Fly     7 AH-ENLVAKAQRSGDADPEVASTASEKQRSSGASAIAVGTEFPGNPQASRPQSLGMYLL------ 64

  Fly    54 VKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPE--NEEFRTK----- 111
                  ||.:.:.:||:..:|.|.:|..:|:||.....:.:.:|:.|....  ||..|.:
  Fly    65 ------EPFILILLFAYNFSSTVLKNEVIYQSCTAGFGYPDSVCQLLGTKNITNETKRIEEQVQP 123

  Fly   112 --AMLTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLM------GLVGKFFYSTMIVVN 168
              |.:|.|..|    :...: |....||.||::|..||| ||||      ||  ::..|..|...
  Fly   124 YAAQVTLAMRL----VECFI-PAFCGLFAGSWADHYGRK-PLLMCSFLGYGL--QYLISAAIAYC 180

  Fly   169 ARMTT------WPVQNIIYSATLPSALTGADVAIFASCFAYISDISSLQQRTIRVTILDVIYLSA 227
            |..|.      |.|.:|:..:.|.|::|   .::.|.||  |:|:|..:.|:.|:    :.|..|
  Fly   181 AMYTQGLVSPWWYVLSIVPLSCLGSSVT---YSVAAVCF--IADVSGGKVRSYRM----IAYELA 236

  Fly   228 MPMGVALGS----HLF-----YNVFNQSYADMFTVNASLLALAIIYTLCALKWQTTPRQRSLREL 283
            :.:|:.|||    :.:     |.||:.|...:||. ..|:||.:..:|.|       |.|:|...
  Fly   237 IYVGLLLGSLGSGYAYEATDAYIVFSISAVCIFTA-LFLMALLLPESLPA-------RNRTLSTP 293

  Fly   284 GCCGFWGDFFDKQHVKDSLAVLVKPRKGHRRSFLIILLVSMALYTFQRD-EGQYLYMYTLGKFDW 347
            ..     |......:|...:...|||:...|..|..::|.:.|..|..| .....|.:...||.|
  Fly   294 TT-----DTSVVSMLKSLWSTCSKPREHQNRFMLTTIMVVLLLTAFVSDGSNSVFYKFMRIKFHW 353

  Fly   348 DVSAYSNFKT-------FKSSAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIARLFFYFATN 405
            .|..::.::|       ...|..|:.:.......|..:.|    :..:...:|..:.|...||..
  Fly   354 TVKQFTEYETVGILVPAVAGSGGVLFIWSLRKCTNSAILW----LALVSLLSHCSSSLMKGFALE 414

  Fly   406 TDLLYAGAVVCSLG---PIVGPMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRR 467
            :..:|   |...||   .:|.||.|.|.:.::|..||||:||||.|.....|.||...|..:|.|
  Fly   415 SWQIY---VAIGLGVFKSLVNPMCRTMITNLLPADERGKIFALLGVLQALSPLISSTLYVAIYTR 476

  Fly   468 TQNTNHGGNVFILTIATQIAVFVMILCLHIVLGKNS 503
            |.||..|    |..:.:.....:.|:.|..|..|.|
  Fly   477 TLNTEPG----IFNVFSAFLFGIGIILLGTVWHKKS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	99/360 (28%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	108/394 (27%)
CG8046	NP_724761.1	MFS_1	138..467	CDD:284993	99/361 (27%)
CG8046	NP_724761.1	MFS	141..503	CDD:119392	109/397 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458938
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	1	1.000	-	-		mtm6480
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
	10	9.900